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Gold particle-loaded silica multi-mode contrast agent and high intensity focused ultrasound (HIFU) synergist

A silica and mesoporous silica technology, applied in the field of nanomaterials, can solve the problems of low spatial/temporal resolution of tissue imaging, inability to meet early disease diagnosis, poor contrast effect, etc. Mode imaging performance with excellent performance and low cost

Inactive Publication Date: 2014-06-11
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the lack of effective contrast agents, the spatial / temporal resolution of tissue imaging is still low, which cannot meet the diagnosis of some early diseases, and its application is still greatly limited.
At the same time, due to the relatively small response of nanoscale materials to ultrasound and poor contrast effect, SiO loaded with fluorocarbons 2 The ultrasonic imaging performance of composite nanocapsule materials needs to be further improved, and the research on more efficient HIFU synergistic therapy under the guidance of multi-mode imaging has not been reported, and there are no related patents to be found, which needs further research

Method used

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  • Gold particle-loaded silica multi-mode contrast agent and high intensity focused ultrasound (HIFU) synergist
  • Gold particle-loaded silica multi-mode contrast agent and high intensity focused ultrasound (HIFU) synergist
  • Gold particle-loaded silica multi-mode contrast agent and high intensity focused ultrasound (HIFU) synergist

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Synthesis of Mesoporous SiO 2Nanocapsules: 35.7mL ethanol, 5mL deionized water and 1.57mL ammonia water were stirred in 30°C water for 30 minutes. Rapidly add 3 mL of tetraethyl orthosilicate (TEOS) and stir for 1 hour. Afterwards, 2.5 mL TEOS and 1 mL octadecyltrimethylsilane (C18TMS) were added and stirred for 1 hour, and the obtained white precipitate was centrifuged. Prepare 0.6M Na 2 CO 3 aqueous solution, add the above white precipitate and etch at 80°C for 0.5 hours with stirring. The obtained precipitate was washed with water three times, dried and then calcined at 550° C. for 6 hours.

Embodiment 2

[0086] Synthesis of ordered mesoporous SiO loaded with fluorescence 2 Nanocapsules: 35.7mL ethanol, 5mL deionized water and 1.57mL ammonia water were stirred in 30°C water for 30 minutes. Rapidly add 3 mL of tetraethyl orthosilicate (TEOS) and stir for 1 hour. Afterwards, add 2 mL of TEOS and then centrifuge and disperse in 14 mL of water; take 2 mL of the above solution, 75 mg of CTAB, 15 mL of deionized water, 15 mL of ethanol and 0.275 mL of ammonia water and stir for 0.5 hours. Finally, 0.125 mL TEOS and 150 uL FITC-APTES were added and stirred at 30° C. for 2 hours. Add 212mg Na to 10mL water 2 CO 3 , add the centrifuged product, react at 50°C for 10 hours, reflux in methanol to remove the surfactant CTAB, and obtain an ordered mesoporous hollow sphere carrier loaded with fluorescence.

Embodiment 3

[0088] 2-4 nanometer gold particles loaded on the nanocapsules with a content of 5%: Repeat the method of Example 1 to obtain 100 mg of hollow nanocapsules dispersed in ethanol, stir and disperse in ethanol, add 100 μl of mercaptosilane coupling agent and reflux at 70 ° C for 8 Hours, sulfhydryl-modified hollow nanocapsules were obtained. Take 0.01M chloroauric acid solution, adjust the pH to 9 with 0.01M NaOH, add the above-mentioned mercapto hollow nanocapsules, then add sodium borohydride to reduce gold particles, and graft gold particles through sulfur-gold chemistry.

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Abstract

The invention relates to a gold particle-loaded mesoporous silica nanocapsule multi-mode contrast agent, which can be used for strengthening drug release, and used as an ultrasonic contrast agent and a high intensity focused ultrasound (HIFU) synergist and an HIFU synergist and a preparation method of the contrast agent. The multi-mode contrast agent and the HIFU synergist comprise mesoporous silica nanoparticle capsules which modified by polyethylene glycol on surfaces and beneficiated by gold nanoparticles, and guest molecules loaded to the mesoporous silica nanoparticle capsules for HIFU synergism.

Description

technical field [0001] The present invention relates to the technical field of nanomaterials, in particular to the technical field of medical nanobiological materials, in particular to a mesoporous silica nanocapsule base loaded with gold nanoparticles that can be used as drug release enhancement, ultrasound contrast agent and HIFU synergist Hybrid materials and methods for their preparation. Background technique [0002] Tumor is a major disease that seriously threatens people's life and health. Its morbidity and mortality are on the rise, accounting for more than 27.12% of the total number of deaths in 2008 (China Statistical Yearbook, 2009). Surgery, radiotherapy and chemotherapy have played a huge role in the past and present in the fight against tumors, but the toxic and side effects cannot be ignored. Although image-guided radiofrequency and microwave ablation of some malignant tumors such as liver cancer can reduce trauma, it still requires percutaneous insertion of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K41/00A61K47/34A61K47/04A61P35/00A61K47/10
Inventor 王霞陈航榕施剑林黄贤良金智渊
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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