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Ginsenoside Rg1-phenyl isocyanate chiral stationary phase filler and preparation method thereof

A technology of phenyl isocyanate and chiral stationary phase, which is applied in the field of analytical chemistry, achieves the effect of simple preparation method and meeting the needs of daily drug analysis and production quality control

Inactive Publication Date: 2014-05-28
KUNMING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Phenyl isocyanate derivatives of ginsenoside Rg1 chiral stationary phase are used as chiral selective agents for chromatographic separation, but there is no report at home and abroad

Method used

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  • Ginsenoside Rg1-phenyl isocyanate chiral stationary phase filler and preparation method thereof
  • Ginsenoside Rg1-phenyl isocyanate chiral stationary phase filler and preparation method thereof
  • Ginsenoside Rg1-phenyl isocyanate chiral stationary phase filler and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0029] In this example, a natural product-ginsenoside Rg1 is used as a raw material, chemically bonded to a silica gel carrier silanized with 3-(aminopropyl)-triethoxysilane through a spacer arm, and then derivatized with benzene isocyanate to prepare to make.

[0030] The specific separation parameters of the amino acid in the reversed-phase mobile phase are as follows:

[0031] The mobile phase was acetonitrile / 0.05% glacial acetic acid-triethylamine buffer salt=90 / 10. The flow rate is 0.4mL / min, and the separation results are shown in the following table and Figures 1 to 9 ; Detection wavelength is 210nm.

[0032] The table shows the separation results of ginsenoside Rg1-phenyl isocyanate chiral immobilization relative amino acid enantiomers in reversed-phase mobile phase:

[0033]

[0034]

[0035] Mobile phase: acetonitrile / 0.05% glacial acetic acid-triethylamine buffer salt=90 / 10. The flow rate was 0.4 mL / min, and the detection wavelength was 210 nm.

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Abstract

The invention discloses a ginsenoside Rg1-phenyl isocyanate chiral stationary phase filler and a preparation method thereof, and relates to the technical field of analytical chemistry; the method comprises the following steps: chemically bonding a natural product, ginsenoside Rg1, onto a silica-gel carrier, and then carrying out derivatization reaction with phenyl isocyanate. By using the ginsenoside Rg1-phenyl isocyanate as a chiral chromatography stationary phase filler, the ginsenoside Rg1-phenyl isocyanate chiral stationary phase filler has a chiral recognition capability and excellent stability performance, can be used in a condition of reversion phase chromatography, and has a certain separating capability to amino acid.

Description

Technical field: [0001] The invention relates to a ginsenoside Rg1-phenyl isocyanate chiral stationary phase filler and a preparation method thereof, belonging to the technical field of analytical chemistry. Background technique: [0002] Chirality is one of the essential attributes of nature on which human beings live. Biological macromolecules such as proteins, polysaccharides, and nucleic acids are all chirality. Optically active chiral substances widely exist in animals and plants. This biological stereoselectivity and stereosynthesis of optically active substances are unique instincts of biological systems. Two chiral compounds that are enantiomers of each other often have large differences in biological activity, pharmacokinetics, and potential toxic and side effects of drugs. Currently, about half of the chemical drugs on the market contain chiral centers. , and about half of them are sold in the form of racemates. For this reason, the health management departments o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/29B01J20/30G01N30/02
Inventor 沈报春郭伟
Owner KUNMING MEDICAL UNIVERSITY
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