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Medicinal composition for reducing blood pressure and preparation method thereof

A composition and technology for lowering blood pressure, applied in the directions of drug combinations, active ingredients of hydroxyl compounds, cardiovascular system diseases, etc., can solve problems such as no literature reports, achieve mild blood pressure lowering effect, relieve blood perfusion deficiency, and improve vasodilation function. Effect

Inactive Publication Date: 2014-05-21
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above-mentioned antihypertensive antihypertensive drugs are all aimed at hypertensive patients, but there is no literature report on therapeutic antihypertensive drugs for prehypertensive patients

Method used

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  • Medicinal composition for reducing blood pressure and preparation method thereof
  • Medicinal composition for reducing blood pressure and preparation method thereof
  • Medicinal composition for reducing blood pressure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: 1000 tablets of the pharmaceutical composition (tablet) for lowering blood pressure according to the present invention, with a total weight of 117.59325 g.

[0045]

[0046] Get the menthol of recipe quantity and mix for subsequent use;

[0047] (1) The auxiliary materials are passed through a 100-mesh sieve and dried at 75°C for 2 hours;

[0048] (2) Mix the starch, microcrystalline cellulose, and carboxymethyl starch sodium according to the formula amount and then mix with the mixed raw material drug menthol with an equal increment method;

[0049] (3) Add 5% povidone K-30 2.3g to make soft material, granulate with 24 mesh sieve, granulate with 20 mesh sieve, and dry at 40-45°C;

[0050] (4) Add 0.29325 g of magnesium stearate to the dry granules, mix evenly, and compress into tablets after content determination.

Embodiment 2

[0051] Embodiment 2: 1000 tablets of the pharmaceutical composition (tablet) for lowering blood pressure according to the present invention, with a total weight of 141 g.

[0052]

[0053] Preparation Process:

[0054] (1) Get the menthol of formula quantity and mix for subsequent use;

[0055] (2) The dressings were passed through a 100-mesh sieve and dried at 75°C for 2 hours;

[0056] (3) Mix the starch, microcrystalline cellulose, and sodium starch glycolate according to the formula amount and then mix them evenly with the mixed bulk drug in equal increments;

[0057] (4) Add 5% povidone K-306.75g to make soft material, granulate with 24 mesh sieve, granulate with 20 mesh sieve, and dry at 40-45°C;

[0058] (5) Add 1.4175 g of magnesium stearate to the dry granules, mix evenly, and compress into tablets after content determination.

Embodiment 3

[0059] Embodiment 3: 1000 capsules of the pharmaceutical composition (capsule) for lowering blood pressure according to the present invention, with a total weight of 90 g.

[0060]

[0061]

[0062] Preparation Process:

[0063] (1) Get the menthol of formula quantity and mix for subsequent use;

[0064] (2) Take the lactose, microcrystalline cellulose, starch and carboxymethyl starch sodium in the formula amount and dry them at about 100°C for 2 hours respectively, and pass through a 100-mesh sieve;

[0065] (3) Mix the above-mentioned excipients and the mixed raw material drug evenly by the method of equal increments, put them in a granulation machine for granulation, the moisture of the granules is >5%, granulate with a 30-mesh sieve, and fill the capsules.

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Abstract

The invention relates to a medicinal composition for reducing blood pressure and a preparation method thereof. The composition comprises menthol and a pharmaceutically acceptable carrier, wherein the menthol accounts for 30-50wt% of the medicinal composition. The medicinal composition is prepared from pure natural plate extract menthol, can be used for effectively and smoothly reducing the blood pressure of a patient in prehypertension (120-139 / 80-89mmHg) and with mild hypertension to improve the vasodilatation function of the patient, and does not have remarkable adverse response. The medicinal composition is particularly suitable for a patient in prehypertension, as well as a patient with confirmed primary hypertension.

Description

technical field [0001] The present invention relates to a kind of medicine composition for lowering blood pressure and preparation method, relate to a kind of medicine composition for lowering blood pressure to be made up of menthol and pharmaceutically acceptable carrier more specifically, its medicine is used for the treatment of prehypertension and Diagnosis and adjunctive treatment of hypertension. Background technique [0002] Hypertension is a major controllable chronic disease in the world. It has become the main cause of stroke, coronary heart disease, and heart and kidney failure. It is also the most important risk factor for cardiovascular and cerebrovascular diseases. Major complications such as kidney disease not only cause disability and high mortality rate, but also consume medical and social resources seriously, causing a heavy burden to the family and the country. At present, the proportion of people with normal blood pressure (<120 / 80mmHg) in my country ...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P9/12A61P9/00
Inventor 祝之明刘道燕
Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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