A kind of preparation method of self-gelling hydrogel freeze-dried powder

Abstract

The invention discloses a preparation method of hydrogel freeze-dried powder capable of self-gelling. The aqueous solution of chitosan is directly mixed with the aqueous solution of polyvinylpyrrolidone or its copolymer, and then left to stand for 10 to 20 days, or Under vacuum condition, stand still for 3-5 days, then freeze-dry and grind to obtain freeze-dried powder. The freeze-dried powder prepared by the method of the invention has good water absorption, and after absorbing water, it swells and coagulates rapidly to form a monolithic hydrogel. The freeze-dried powder is used for wounds and can play a role in hemostasis. Since the formed hydrogel is self-adaptive, the freeze-dried powder is suitable for complex-shaped wounds and cave-type wounds. The hydrogel freeze-dried powder prepared by the method of the invention has good biocompatibility because it does not contain components such as small molecular monomers, initiators, crosslinking agents, and has greater advantages as dressing materials.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a preparation method of self-gelling hydrogel freeze-dried powder. Background technique [0002] Hydrogel materials are a class of polymers with a three-dimensional network structure that have hydrophilic groups and are water-swellable but insoluble in water. Hydrogels can hold a large amount of water and are very soft, similar to biological tissues. They have good biocompatibility and can be directly used in human tissues, so they have broad application prospects in the field of biomedicine, such as wound dressings , drug carrier materials, medical coatings, cell culture substrates, anti-adhesion materials and the fixation of biological enzymes, etc. [0003] There are many methods for preparing hydrogels, among which crosslinking by monomer polymerization is the most commonly used method. The disadvantage of this method is that residual components such as small mole...

AI Technical Summary

Problems solved by technology

[0003] There are many methods for preparing hydrogels, among which cross-linking by monomer polymerization is the most commonly used method. The disadvantage of this method is that residual components such as small molecule monomers, initiators, and cross-linking agents are difficult to completely remove.

The disadvantage of radiation crosslinking is that the molecular chain will be degraded during the irradiation process, which will destroy the molecular structure and stability. This technology has limitations for easily degradable polymer materials.

There are also literatures that point out that PVP with a molecular weight of not less than K-60 undergoes high-temperature and high-pressure ring-opening treatment to generate -COOH groups, and then reacts with chitosan to form a hydrogel through the hydrogen bond between the two molecules. It is difficult for polyvinylpyrrolidone to form a gel directly with chitosan without ring-opening treatment