Anticoagulation coating material and preparation method thereof

Abstract

The invention discloses an anticoagulation coating material and a preparation method thereof. The anticoagulation coating material comprises sodium hyaluronate and hirudin, wherein the sodium hyaluronate is formed into a gel network; the hirudin is in covalent binding with the sodium hyaluronate. The preparation method of the anticoagulation coating material comprises the following steps: (1) preparing an MES (Fatty Acid Methyl Ester Sulfonate) buffer solution; (2) preparing a sodium hyaluronate solution with the concentration of 1mg / ml to 20mg / ml; (3) preparing a hirudin solution with the concentration of 1mg / ml to 10mg / ml; (4) uniformly mixing up the two solutions so as to enable the mass ratio of the hirudin to the sodium hyaluronate to be 1:1 to 1:10; (5) adding a crosslinking agent into the mixture solution obtained in the step (4), uniformly mixing up so as to covalently crosslink the hirudin and the sodium hyaluronate. The anticoagulation coating material disclosed by the invention is high in anticoagulation activity, stable in effect, long in lasting time, good in biocompatibility, simple in preparation method, gentle in condition and applicable to large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and more specifically relates to an anticoagulant coating material and a preparation method thereof. Background technique [0002] Anticoagulant biomedical materials are an important class of biological materials, which are widely used in medical materials in contact with human blood and tissues, such as hemodialysis systems, extracorporeal circulation systems, artificial heart valves, cardiac pacemakers, artificial blood vessels , vascular stents, surgical lines and catheters, etc. In the 21st century, the morbidity and mortality of cardiovascular diseases are on the rise, and the prevention and treatment of cardiovascular diseases has become the focus of medical circles at home and abroad. Anticoagulant biomedical materials have important application value. [0003] At present, there are anticoagulant coatings, mainly using heparin as an anticoagulant factor, and heparin is fixed on the su...

AI Technical Summary

Problems solved by technology

[0005] In view of the above defects or improvement needs of the prior art, the present invention provides an anticoagulant coating material, the purpose of which is to combine the anticoagulant factor hirudin, which has a small molecular weight and stable anticoagulant effect, with a good biological phase. The capacitive sodium hyaluronate gel network is covalently bonded, thereby solving the technical problems of unstable or short-term anticoagulant effect and poor biocompatibility of current anticoagulant coating materials

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