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Preparation of alpha-hederin solid dispersion and its cyclodextrin inclusion compound

A technology of hedera saponin and solid dispersion, which is applied in the directions of non-active ingredients of medical preparations, non-active ingredients of polymer compounds, and medical preparations containing active ingredients, etc., can solve problems affecting the development of unilateral preparations, poor absorption, - Problems such as poor water solubility of ivy saponins

Inactive Publication Date: 2014-04-02
JIANGXI HERBFINE HI TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor water solubility and poor absorption of α-hedera saponin, the development of its single preparation is affected, so improving the solubility of α-hedera saponin is one of the urgent problems to be solved.

Method used

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  • Preparation of alpha-hederin solid dispersion and its cyclodextrin inclusion compound
  • Preparation of alpha-hederin solid dispersion and its cyclodextrin inclusion compound
  • Preparation of alpha-hederin solid dispersion and its cyclodextrin inclusion compound

Examples

Experimental program
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Embodiment Construction

[0039] The following examples illustrate the solubility, in vitro dissolution rate and relative bioavailability of the ɑ-hedera saponin solid dispersion and ɑ-hedera saponin cyclodextrin inclusion compound of the present invention, and compare with the original drug; In addition, the advantages and disadvantages of each preparation method are compared with the encapsulation rate and bioavailability as indicators, and the significance of the present invention is more clearly explained. The present invention is not limited to the examples.

[0040]

[0041]

[0042] result

[0043] Above embodiment result shows:

[0044] (1) Among the prepared solid dispersions, the α-hedera saponin solid dispersion prepared by solvent melting method with PEG-4000 as the carrier was the best.

[0045] (2) Among the cyclodextrin inclusion compounds prepared, the α-hedera saponin cyclodextrin inclusion compound prepared by using hydroxypropyl-β-cyclodextrin as inclusion material and saturat...

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Abstract

The invention relates to preparation of a Fructus Akebiae alpha-hederin solid dispersion and an alpha-hederin cyclodextrin inclusion compound. In the solid dispersion, the alpha-hederin and a solid dispersion carrier are in a weight ratio of 1:1-1:200; and in the cyclodextrin inclusion compound, the alpha-hederin and cyclodextrin are in a mole ratio of 1:1-1:20. After preparation of the solid dispersion and the inclusion compound, the solubility, dissolution rate and bioavailability of alpha-hederin can be significantly improved.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a preparation method of a monomeric saponin solid dispersion and a cyclodextrin inclusion compound thereof, in particular to the preparation of a-hedera saponin solid dispersion and a-hedera saponin cyclodextrin inclusion compound method. Background technique [0002] Fuzhizi is the dried fruit of Mutong, Sanye Mutong or Bai Mutong, which is a commonly used traditional Chinese medicine. Bitter in taste, cold in nature, it belongs to the liver, gallbladder, stomach and bladder meridian, has the effects of soothing the liver and regulating qi, promoting blood circulation and relieving pain, dispelling stagnation, and diuresis. Modern pharmacological research has found that Semen Predict has anti-inflammatory, anti-tumor, anti-thrombosis, diuretic and other effects. ɑ-hedera saponin is one of the total saponins of Pregnominus chinensis. Pharmacological studie...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K47/34A61K47/40A61P1/12A61P1/16A61P35/00A61P43/00
Inventor 杨世林罗晓健冯育林李东勲饶小勇
Owner JIANGXI HERBFINE HI TECH
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