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Neutral restoration catheter support of multilayer structure and manufacturing method of neutral restoration catheter support

A technology for nerve repair and catheter stent, applied in the field of biodegradable polymer nerve repair catheter stent and its preparation, can solve the problem of insufficient mechanical strength and cell growth space, electrospinning lack of mechanical strength, cell culture and implantation. Inconvenient operation and other problems, to achieve the effect of short preparation time, good biocompatibility, and low cost

Inactive Publication Date: 2014-03-26
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the lack of necessary mechanical strength of electrospinning, it is inconvenient for the cell culture and implantation operation of this type of scaffold before implantation in vivo.
Although integrated into other biomaterials, none of them can fully satisfy sufficient mechanical strength and cell growth space

Method used

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  • Neutral restoration catheter support of multilayer structure and manufacturing method of neutral restoration catheter support
  • Neutral restoration catheter support of multilayer structure and manufacturing method of neutral restoration catheter support
  • Neutral restoration catheter support of multilayer structure and manufacturing method of neutral restoration catheter support

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Proceed as follows:

[0034] (1) Weigh 3g of racemic polylactic acid and dissolve in 20ml of dichloromethane, heat and reflux for 1 hour to form solution A;

[0035] (2) Weigh 0.3g caprolactone lactate copolymer and dissolve it in 10ml of dichloromethane and N-dimethylamide (volume ratio: 7:3) mixed solvent, heat and reflux for 1 hour to form solution B ;

[0036] (3) Weigh 0.6g of L-polylactic acid and dissolve it in 10ml of mixed solvent of dichloromethane and N-dimethylamide (volume ratio: 7:3), heat and reflux for 1 hour to form solution C;

[0037] (4) Insert a stainless steel rod with a diameter of 3 mm into the above solution A, take it out vertically immediately after moderate stirring, place it upside down in a ventilated place, and volatilize at room temperature for more than 6 hours to obtain the inner tube;

[0038] (5) Set up the injection platform I, the syringe needle is a No. 5 flat-angle needle, and the distance between the needle tip and the receivin...

Embodiment 2

[0043] Proceed as follows:

[0044] (1) Weigh 2g of racemic polylactic acid and dissolve in 20ml of dichloromethane, heat and reflux for 1 hour to form solution A;

[0045] (2) Weigh 0.3g caprolactone lactate copolymer and dissolve it in 10ml of dichloromethane and N-dimethylamide (volume ratio: 7:3) mixed solvent, heat and reflux for 1 hour to form solution B ;

[0046] (3) Weigh 0.6g of L-polylactic acid and dissolve it in 10ml of mixed solvent of dichloromethane and N-dimethylamide (volume ratio: 7:3), heat and reflux for 1 hour to form solution C;

[0047] (4) Insert a stainless steel rod with a diameter of 3 mm into the above solution A, take it out vertically immediately after moderate stirring, place it upside down in a ventilated place, and volatilize at room temperature for more than 6 hours to obtain the inner tube;

[0048] (5) Set up the injection platform I, the syringe needle is a No. 5 flat-angle needle, and the distance between the needle tip and the receivin...

Embodiment 3

[0053] Proceed as follows:

[0054] (1) Weigh 3g of racemic polylactic acid and dissolve in 20ml of dichloromethane, heat and reflux for 1 hour to form solution A;

[0055] (2) Weigh 0.2g caprolactone lactate copolymer and dissolve it in 10ml of dichloromethane and N-dimethylamide (volume ratio: 7:3) mixed solvent, heat and reflux for 1 hour to form solution B ;

[0056] (3) Weigh 0.8g of L-polylactic acid and dissolve it in 10ml of mixed solvent of dichloromethane and N-dimethylamide (volume ratio: 7:3), heat and reflux for 1 hour to form solution C;

[0057] (4) Insert a stainless steel rod with a diameter of 2 mm into the above solution A, take it out vertically immediately after moderate stirring, place it upside down in a ventilated place, and volatilize at room temperature for more than 6 hours to obtain the inner tube;

[0058] (5) Set up the injection platform I, the syringe needle is a No. 5 flat-angle needle, and the distance between the needle tip and the receivin...

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Abstract

The invention provides a neutral restoration catheter support of a multilayer structure and manufacturing method of the neutral restoration catheter support in order to meet requirements of neural tissue engineering. The neutral restoration catheter support structurally comprises an inner pipe, a middle pipe and an outer pipe which are made of incompletely different materials, the inner pipe is made of poly-dl-lactide, the middle pipe is made of a lactic acid caprolactone copolymer, and the outer pipe is made of poly-l-lactide. The neutral catheter support is characterized in that the support has certain mechanical performance, is bendable and extrudable, is 10-15MPa in tensile strength and 5-13% of tensile deformation and can restore to an original form after being bent or extruded.

Description

technical field [0001] The invention relates to a biodegradable polymer nerve repair catheter bracket with a multi-layer structure and a preparation method thereof, belonging to the field of nerve tissue engineering. Background technique [0002] Alternative repair of defects after peripheral nerve injury has always been a worldwide problem. At present, autologous nerve transplantation is mainly used to repair peripheral nerve defects in clinical practice, but there are many problems such as that autologous nerve transplantation will cause secondary damage to the patient, and the operation is difficult, and it is difficult for the patient to fully recover. The use of artificial nerve grafts as scaffolds to repair peripheral nerve defects has become a research hotspot in the field of peripheral nerves in recent years. It is expected to replace autologous nerve grafts to repair peripheral nerve defects, but no ideal products have appeared so far. [0003] Current research sug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/02A61L27/40A61L27/56A61L27/18
Inventor 魏岱旭钟建何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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