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Ephedra and bitter apricot kernel cough capsule and preparation technology thereof

The invention relates to a technique for relieving cough and preparation technology of Maxing, which is applied to the field of Maxing Zhike capsule and its preparation technology, and can solve the problems of bioavailability of liver and intestine first-pass effect, influence on treatment effect, long disintegration time, etc. The process equipment is simple and the effect of improving the efficacy of the drug

Active Publication Date: 2014-03-19
GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above preparations are all derived from the "Maxing Shigan Decoction" in Zhang Zhongjing's "Treatise on Febrile Diseases". After taking it, there are problems such as long disintegration time, low dissolution rate, poor absorption, hepatic first-pass effect and low bioavailability. Thus affecting the efficacy of the drug and directly affecting the therapeutic effect

Method used

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  • Ephedra and bitter apricot kernel cough capsule and preparation technology thereof
  • Ephedra and bitter apricot kernel cough capsule and preparation technology thereof
  • Ephedra and bitter apricot kernel cough capsule and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 A maxing cough-relieving capsule, which is made of the following raw materials in parts by weight: 700g of ephedra, 500g of bitter almond, 1500g of honeysuckle, 500g of Fritillaria chinensis, 500g of Baibu, 500g of Platycodon grandiflorum and 400g of licorice.

[0040] The preparation technology of this maxing cough capsule comprises the following steps:

[0041] ⑴ Weighing according to the proportion.

[0042] (2) After deoiling bitter almonds by conventional methods, add water 4 to 12 times its mass, ultrasonically extract for 30 to 50 minutes at a temperature of 60 to 80 °C and a power of 200 to 400 W, and filter to obtain filtrate A.

[0043] (3) Mix ephedra, honeysuckle, Fritillaria chinensis, Licorice root, Platycodon grandiflora, and licorice, and grind them to 10 meshes to obtain a mixture, then add water 6 to 10 times its mass to the mixture, and heat it at a temperature of 50~75°C and power Under the condition of 100~500W, ultrasonically extract...

Embodiment 2

[0047] Example 2 A Maxing Cough Capsule, which is made of the following raw materials in parts by weight: 1100g of ephedra, 800g of bitter almond, 2000g of honeysuckle, 800g of Chuan Fritillaria, 800g of Baibu, 800g of Campanulaceae and 600g of Licorice.

[0048] The preparation process of the Maxing Zhike Capsule is the same as Example 1 .

Embodiment 3

[0049] Example 3A maxing cough-relieving capsule, which is made of the following raw materials in parts by weight: 800g of ephedra, 600g of bitter almond, 1600g of honeysuckle, 600g of Fritillaria chinensis, 600g of Baibu, 600g of bellflower, and 500g of licorice.

[0050] The preparation process of the Maxing Zhike Capsule is the same as Example 1 .

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Abstract

The invention relates to an ephedra and bitter apricot kernel cough capsule. The capsule is prepared from the following raw materials in parts by weight: 700-1100 parts of ephedra, 500-800 parts of bitter apricot kernel, 1500-2000 parts of honeysuckle, 500-800 parts of fritillaria cirrhosa, 500-800 parts of radix stemonae, 500-800 parts of platycodon grandiflorum and 400-600 parts of liquorice. The ephedra and bitter apricot kernel cough capsule has the characteristics of being high in bioavailability, quick to release, small in toxic and side effects, high in drug content, small in dose, and convenient to carry.

Description

technical field [0001] The invention relates to a medicine with antitussive, expectorant and antiasthmatic properties, and is used for symptoms such as acute and chronic bronchitis and wheezing, in particular to a maxing cough capsule and a preparation process thereof. [0002] Background technique [0003] Cough, phlegm, wheezing, and bronchitis are all clinically common diseases. Although there are some medicines for the treatment of related symptoms on the market, their therapeutic effects are not obvious, or the side effects are relatively large, which is not ideal. the therapeutic effect. Chinese patent CN 1634476A discloses a maxing cough dropping pill and a preparation method thereof, with maxing, bitter almond, gypsum and roasted licorice as main components. The national drug standard WS-10757 (ZD-0757)-2002 published the formula and extraction process of maxing cough syrup. The formula is maxing, bitter almond, gypsum, roasted licorice, sucrose and sorbic acid. ...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61K9/48A61P11/14A61P11/10A61P11/06A61P11/00
Inventor 康海军张喜民越庆鑫康永红邓月婷任一杰王小芳
Owner GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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