A compound traditional Chinese medicine preparation for regressing and reversing atherosclerotic plaque and its preparation method

A technology of atherosclerosis and compound traditional Chinese medicine, applied in the field of medicine, can solve the problems of liver, kidney and muscle toxicity, and achieve the effect of reducing cardiovascular and cerebrovascular events, reducing the burden of liver and kidney, and reducing the risk of liver and kidney toxicity

Active Publication Date: 2019-06-14
吴宗贵
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although statins and other blood lipid-regulating drugs are widely used clinically, their effect on the plaques that have already formed is not obvious, and they often need to be taken in large doses for a long time, which brings corresponding problems such as liver, kidney and muscle toxicity. A key issue that urgently needs to be addressed

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  • A compound traditional Chinese medicine preparation for regressing and reversing atherosclerotic plaque and its preparation method
  • A compound traditional Chinese medicine preparation for regressing and reversing atherosclerotic plaque and its preparation method
  • A compound traditional Chinese medicine preparation for regressing and reversing atherosclerotic plaque and its preparation method

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preparation example Construction

[0018] A method for preparing a compound Chinese medicine preparation for regressing and reversing atherosclerotic plaque, characterized in that: the preparation method is a preparation method of decoction and alcohol precipitation, and the specific steps are as follows: a, the compound Chinese medicine preparation is made by weight The percentage is 50-100% of the main material and 0-50% of the auxiliary material. The main material is composed of the three traditional Chinese medicines of Trichosanthes mellifera, Xiebai and Panax notoginseng, and 10-10% of the total weight of the medicinal materials is added to the above mixture. 20 times the water decoction, the decoction time is 2-6 hours; b. The decoction obtained after decoction passes through a 40-mesh vibrating screen device for solid-liquid separation, and the separated water extract is processed on a thin film concentrator. Concentrate under reduced pressure, and then transfer to a stainless steel pressure cooker for a...

Embodiment 1

[0058] The production process of compound preparation granule powder for stabilizing and regressing atherosclerosis, after mixing the three herbal medicines of Gualou, Xiebai and Sanqi according to the weight ratio of 3:2:1, add 10 times of water to decoct, and the extraction time is 5 hours , through a 40-mesh vibrating sieve device, solid-liquid separation is carried out, and the separated water extract is concentrated under reduced pressure on a thin-film concentrator, and then transferred to a stainless steel pressure cooker for atmospheric concentration. The amount of liquid extract after concentration should be controlled at Each 1ml is equivalent to 6-10g of Chinese medicinal materials, add 95% ethanol, 60% alcohol content, stir well and let it stand for 48 hours, filter the alcohol precipitation liquid, put the ethanol in the alcohol recovery pot to recover the ethanol until it has no alcohol smell, the above The extract continues to be concentrated until each 1ml of ex...

Embodiment 2

[0060] Mix 3 parts of Gualou, 2 parts of Allium, 1 part of Sanqi, 1 part of Fritillaria, 1 part of Pinellia, and 1 part of Coptidis Rhizoma, add 10 times of water to decoct, extract for 5 hours, pass through a 40-mesh vibrating sieve device, for solid-liquid separation, the separated water extract is concentrated under reduced pressure on a thin-film concentrator, and then transferred to a stainless steel pressure cooker for atmospheric concentration. 6-10g, add 95% ethanol, 60% alcohol content, stir well and let it stand for 48 hours, filter the alcohol precipitation liquid, put it in the alcohol recovery pot to recover the ethanol until there is no alcohol smell, and continue to concentrate the above extract to 1ml of extract is equivalent to 8-12g of Chinese herbal medicine, then add 6% crospovidone-70% ethanol to prepare soft material, and then make wet granules in a 16-mesh stainless steel sieve oscillating granulator. Spread the wet granules evenly on the baking pan, and...

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Abstract

The present invention relates to a compound traditional Chinese medicine preparation with an effect of atherosclerotic plaque regression and reversal. The compound traditional Chinese medicine preparation is characterized by comprising three main traditional Chinese medicines such as fructus trichosanthis, longstamen onion bulb and sanchi and a certain auxiliary herb, wherein a weight percentage ratio of the sanchi to the longstamen onion bulb to the fructus trichosanthis is 1:1-3:1-4, and the amount of the three main traditional Chinese medicines is 50-100% of the total weight of the preparation. According to the present invention, during use, based on effective and stable inhibition of atherosclerosis pathological change progression, plaque regression induction is achieved so as to achieve the pre-displacement of the whole treatment time window, such that the occurrence probability of various types of cardiovascular and cerebrovascular events caused by atherosclerosis pathological changes can be fundamentally reduced. In addition, compatibility of the compound traditional Chinese medicine preparation is optimized and improved so as to reduce burdens on liver, kidney and other organs and reduce risks of liver and kidney toxicity caused by the traditional statin drug intensification therapy.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound traditional Chinese medicine preparation for regressing and reversing atherosclerotic plaque and a preparation method thereof. Background technique [0002] With the improvement of human living standards, the acceleration of the pace of work and life, and the aggravation of social aging, cardiovascular and cerebrovascular diseases based on atherosclerosis (AS) have a high incidence, mortality, and The disability rate has become the most important disease that seriously endangers human health. The incidence rate in my country is increasing year by year, and it is developing towards younger age. The annual total death toll in my country is 35%-40%, and the cost of treating AS vascular diseases is more than 100 billion yuan. All countries in the world regard the study of AS and its complications as the top priority of cardiovascular and cerebrovascular disease research. A...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8962A61K36/8966A61K36/9064A61P9/10
Inventor 吴宗贵梁春贺治青伍锋郭方圆纪瑞圳俞诚虹朱琳王新黄骁卢宏泉
Owner 吴宗贵
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