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Hollow fiber membrane for blood treatment and hollow fiber membrane-type blood treatment apparatus

A technology of blood treatment and fiber membrane, applied in the direction of fiber chemical characteristics, membrane, membrane technology, etc., can solve the problems of high air permeability of hollow fiber membrane, difficult to distinguish pinholes, etc., achieve high stability, easy start-up, high Effect of Membrane Properties

Active Publication Date: 2014-02-26
ASAHI KASEI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] However, in recent years, in the case of a hollow fiber membrane blood processing device using a hollow fiber membrane with high water permeability, the air permeability of the hollow fiber membrane is very high, so it is difficult to determine the presence or absence of pinholes by the above-mentioned method.
Specifically, in the highly permeable membrane whose UFR (ultrafiltration rate) exceeds 40mL / (hr·mmHg) described in the examples described in detail later, the above phenomenon is remarkable and becomes a big problem in realizing high membrane performance.

Method used

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  • Hollow fiber membrane for blood treatment and hollow fiber membrane-type blood treatment apparatus
  • Hollow fiber membrane for blood treatment and hollow fiber membrane-type blood treatment apparatus
  • Hollow fiber membrane for blood treatment and hollow fiber membrane-type blood treatment apparatus

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0270] In the above-mentioned preparation process of the spinning dope, in order to adjust the content A of the hydrophilic polymer to 3% by mass or more and 10% by mass or less, the dosages of the polysulfone-based polymer and the hydrophilic polymer are adjusted.

[0271] Examples of the common solvent in the spinning dope include solvents such as sulfolane and dioxane, or mixtures of two or more of the above solvents, in addition to the above. In addition, in order to control the pore diameter of the target hollow fiber membrane, additives such as water may also be added to the spinning dope.

[0272] In the process of forming a hollow fiber membrane, as the aforementioned annular slit opening 233 having a double-tube structure, a tube-in-orifice type spinneret is used, and the orifice of the spinneret is The spinning dope is ejected from the tube into the air simultaneously with the hollow inner liquid for coagulating the spinning dope. As the hollow inner liquid, water o...

Embodiment 1

[0403] Prepare a homogeneous spinning dope containing the following ingredients:

[0404] PSf (Solvay Advanced Polymers, L.L.C. manufacture, P-1700) 17 parts by mass

[0405] 4 parts by mass of PVP (manufactured by ISP, K-90)

[0406] 79 parts by mass of dimethylacetamide (hereinafter DMAC).

[0407] Here, PSf represents a polysulfone resin, and PVP represents polyvinylpyrrolidone.

[0408] A 42% by mass aqueous solution of DMAC was used as the hollow inner liquid, and it was ejected from the spinneret together with the spinning dope.

[0409] At this time, the discharge amounts of the spinning dope and the hollow inner liquid were adjusted so that the film thickness after drying was 45 μm and the inner diameter was 185 μm.

[0410] The sprayed spinning dope is immersed in a 60°C coagulation bath composed of water set at 50 cm directly below, and then introduced into a hot air dryer after passing through a coagulation process and a water washing process (washing treatment) ...

Embodiment 2

[0416] Before passing the coating solution into the hollow fiber membrane, pass 120 mL of an aqueous solution consisting of 80 parts by mass of 2-propanol and 20 parts by mass of distilled water, and perform flash evaporation with 0.3 MPa air for 10 seconds.

[0417] Furthermore, the α-tocopherol concentration of the coating solution was set to 0.05% by mass.

[0418] Other conditions were the same as in Example 1, and a hollow fiber membrane blood processing device was obtained.

[0419] In this hollow fiber membrane type blood processing device, the amount of fat-soluble vitamin (α-tocopherol) present on the entire surface of the hollow fiber membrane is 0.5 mg per 1 g of the membrane, and the inner surface of the hollow fiber membrane has high hydrophilicity. The presence ratio B of the molecule (PVP) was 46% by mass, and the content A of the hydrophilic polymer (PVP) in the entire hollow fiber membrane was 3% by mass.

[0420] The results obtained by measuring various pro...

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Abstract

To obtain a hollow fiber membrane for blood treatment, which has high membrane performance, allows for a reduction in false positives for leakage, has excellent anti-oxidation performance and blood compatibility, is low-risk in terms of elution of hydrophilic polymer and hollow fiber leakage, is easy to prime, and has high transmission performance stability in a harsh environment. A hollow fiber membrane for blood treatment, the hollow fiber membrane comprising a hydrophilic polymer, a polysulfone-based resin, and a fat-soluble vitamin, wherein: a hydrophilic polymer content (A), which is the mass ratio of the hydrophilic polymer with respect to the total mass of the hydrophilic polymer and the polysulfone-based resin in the entire hollow fiber membrane for blood treatment, is 3-10 mass%; a hydrophilic polymer prevalence (B), which is the mass ratio of the hydrophilic polymer with respect to the total mass of the hydrophilic polymer and the polysulfone-based resin in an inner surface of the hollow fiber membrane for blood treatment, is 35-50 mass%; and the fat-soluble vitamin prevalence in the entire surface of the hollow fiber membrane for blood treatment is 0.5-25 mg per 1g of the hollow fiber membrane.

Description

technical field [0001] The present invention relates to a hollow fiber membrane for blood treatment and a hollow fiber membrane type blood treatment device. Background technique [0002] Conventionally, hollow fiber membrane blood treatment devices using permeable permeable membranes have been widely used in the field of extracorporeal blood circulation such as hemodialysis, heart surgery, blood oxygen supply, and plasma separation. [0003] In recent years, especially in the field of blood treatment membranes such as dialysis membranes, gas exchange membranes, and blood component separation membranes, hollow fiber membranes ( Hereinafter, it is sometimes abbreviated as hollow fiber membrane). [0004] As the constituent material of the aforementioned hollow fiber membrane for blood treatment, if only highly hydrophobic polysulfone is used, sufficient blood compatibility cannot be obtained, so a compound of polysulfone with a hydrophilic polymer such as polyvinylpyrrolidone...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/18B01D63/02B01D69/08B01D71/44B01D71/68D01F6/00D01F6/76D01F6/94
CPCB01D71/68B01D2323/12B01D63/02B01D69/087B01D2325/36B01D69/08B01D2323/42A61M1/16B01D69/0871B01D71/441B01D71/54
Inventor 佐藤淳也森幸一郎
Owner ASAHI KASEI MEDICAL CO LTD
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