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Solid-phase microecology preparation used for treating alcoholic liver injuries, and preparation method thereof

A technology for alcoholic liver injury and solid preparations, which is applied in the field of micro-ecological solid preparations and its preparation, can solve the problems of short survival time of probiotics, increased production costs of compound bacteria, and general effects, etc., to achieve suitable scale production and cycle time Short, Visible Effects

Active Publication Date: 2014-02-26
内蒙古双奇药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there are related technologies in China, CN201110432768.2, CN201210005581.9, the above patented technology involves a liquid drink, and its disadvantage is that the survival time of probiotics in the liquid is relatively short
The composite strains used in the above patented technologies increase the production cost, and the effect is mediocre

Method used

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  • Solid-phase microecology preparation used for treating alcoholic liver injuries, and preparation method thereof
  • Solid-phase microecology preparation used for treating alcoholic liver injuries, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The production technology of embodiment 1. Bifidobacterium longum NQ-1501 bacterial strain bacterial powder

[0024] Bifidobacterium longum NQ-1501 strain from Shuangqi Company was selected as the only strain of the preparation.

[0025] Optimal fermentation medium for Bifidobacterium longum NQ-1501 strain: 1.2% lactose, 0.8% beef extract, 0.4% triamine citrate, 0.4% potassium acetate, 0.04% magnesium sulfate, 0.05% L-cysteine salt, 0.08% Tween-80.

[0026] Bifidobacterium longum NQ-1501 was anaerobically cultured in its fermentation medium, the fermentation temperature was 40°C, and the optimum fermentation time was 8 hours. Centrifuge the obtained fermented liquid at 15000g for 30 minutes, discard the supernatant to obtain a wet bacterial sludge, add a protective agent, stir evenly, pour it into a freeze dryer and freeze-dry to obtain a white powdery bacterial powder. The formula of the protective agent is: add 20ml of 60% skimmed milk powder and 5ml of 5% starch to...

Embodiment 2

[0027] Embodiment 2. The making of the microecological solid preparation for the treatment of alcoholic liver injury

[0028] The Bifidobacterium longum NQ-1501 bacteria powder and the auxiliary material starch are fully mixed according to the ratio of 1:9, and made into tablets, capsules and powders.

[0029] a. Fully mix Bifidobacterium longum NQ-1501 bacteria powder and auxiliary material starch according to the ratio of 1:9, and press it into flat tablets on both sides with a tablet machine, with an average tablet weight of 0.4g, 1g of tablet weight, and live bacteria The number is about 20 billion, and the dosage for adults is 2 tablets a day, and 30 days is a course of treatment.

[0030] b. Fully mix Bifidobacterium longum NQ-1501 bacteria powder and auxiliary material starch according to the ratio of 1:9, and put it in a capsule in a cylindrical rubber shell made of gelatin as the main raw material. The volume of the capsule is 0.48ml , The number of viable bacteria i...

Embodiment 3

[0032] Example 3. Liver-protecting and liver-protecting properties of probiotic solid preparations for the treatment of alcoholic liver injury

[0033] 1. Experimental materials:

[0034] 1. Experimental preparation:

[0035] The microecological solid preparation containing Bifidobacterium longum NQ-1501 for the treatment of alcoholic liver injury is provided by Inner Mongolia Shuangqi Pharmaceutical Co., Ltd.

[0036] 2. Experimental animals:

[0037] Adult Wistar male mice, weighing 18±22 grams, were provided by the Animal Experiment Center of Inner Mongolia University.

[0038] 3. Experiment kits:

[0039] Triglyceride (TG enzyme method) test kit, serum very low density lipoprotein (VLDL) ELISA kit.

[0040] 2. Experimental method:

[0041] The mice were randomly divided into 5 groups, namely blank control group, model group, and test sample group, and the test sample group was divided into high (90mg / kg.BW), medium (45mg / kg.BW), low (22.5mg / kg.BW) dose group, 10 rats...

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Abstract

The invention discloses a solid-phase microecology preparation used for treating alcoholic liver injuries, and a preparation method thereof. According to the preparation method, the solid-phase microecology preparation is prepared by following steps: bifidobacterium longum NQ-1501 bacterial strains are made into bacterial powder; and the bacterial powder is mixed with auxiliary materials. The solid-phase microecology preparation is capable of treating alcoholic liver injuries, adjusting intestinal floras, and mitigating damages on human body caused by alcohol.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to a microecological solid preparation capable of treating alcoholic liver injury and regulating intestinal flora and a preparation method thereof. Background technique [0002] Worldwide, per capita alcohol consumption is on the rise, and various problems caused by drinking have become one of the more serious public health problems. According to the survey, the death rate of long-term alcoholics is 1-3 times higher than that of ordinary residents. In countries such as Europe and the United States, alcoholic liver disease is one of the main causes of death among young and middle-aged people. In the United States, 85,000 people die from alcohol-related diseases every year. The liver is one of the important organs of the human body and plays an extremely important role in metabolism. When ethanol enters the liver cells, it is oxidized to acetaldehyde through t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61P1/16A61P1/00A61K35/745
Inventor 刘彦民黄少磊李康宁程超王春颖冯谦李晓军刘斌龚虹李云旭马晓红邢会霞马跃英
Owner 内蒙古双奇药业股份有限公司
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