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Clean technology for extracting tabersonine from Voacanga chalotiana Pierre ex Stapf

A technology of boning and boll fruit, applied in the field of plant extraction, can solve the problems of high cost of industrialized production, large consumption of organic solvents, and many operation steps, so as to reduce the amount of material handling, the amount of solvent used, and the amount of solvent used. effect of dosage

Active Publication Date: 2014-02-19
重庆恒芯紫来科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. The extraction rate of active ingredients is low, and the consumption of organic solvents is large, resulting in high industrial production costs
[0006] 2. The amount of acid and alkali used is large, the requirements for corrosion resistance of equipment are high, and the amount of wastewater treatment is large
[0007] 3. The use of various toxic organic solvents is large, and recycling is difficult, which is not conducive to the health of production personnel and environmental protection
[0008] Taking the technology disclosed in the closest comparative document CN201010602111.1 as an example, acid-base immersion is used, and the pH is adjusted repeatedly, which requires a large amount of acid-base and many operating steps; Large amount of wastewater treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Potato fruit pretreatment: drying, peeling and crushing the potato seeds to pass through a No. 5 sieve for later use.

[0029] Superfine crushing treatment: crush the crushed potato fruit into superfine powder.

[0030] Extraction and separation: take 10Kg ultrafine powder, add 20L ethyl acetate, act under 200W ultrasound for 30 minutes at room temperature, centrifuge, and use the filtrate for later use;

[0031] Add 30L of ethyl acetate to the filter residue to reflux and extract twice, each time for 1 hour; combine the first extraction with the centrifugal liquid after ultrasonication, heat and concentrate until no condensate drips out, and the obtained condensate is the solvent, which can be recycled; The second extraction solution is used as the first extraction solvent of the next batch;

[0032] Add 1 times the volume of 8% TritionX-114 aqueous solution to the obtained concentrated solution, stir at 45°C for 1 hour, centrifuge, and use the centrifugate for re-cal...

Embodiment 2

[0035] Potato fruit pretreatment: drying, peeling and crushing the potato seeds through an 80-mesh sieve.

[0036] Superfine pulverization treatment: Superfine pulverization of the pulverized powder.

[0037] Extraction and separation: Take 20Kg of powder, add 50L of ethyl acetate, act under 200W ultrasound for 45 minutes at room temperature, centrifuge, and use the filtrate for later use;

[0038] Add 40L of ethyl acetate to the filter residue to reflux and extract twice, 1 hour each time; combine the first extract with the centrifuge after ultrasonication, concentrate to 1 / 2 of the original volume, and collect the solvent obtained from the concentrated treatment for later use; the second extract Ready to be used as the first extraction solvent for the next batch;

[0039] Add 1.5 times the volume of 7% TritionX-114 aqueous solution to the concentrated solution, stir at 45°C for 0.5 hours, centrifuge, add 0.5L water to the solid, stir for 15 minutes, let stand, and separate ...

Embodiment 3

[0042] Potato fruit pretreatment: drying, peeling and crushing the potato fruit seeds to pass through a 50-mesh sieve.

[0043] Superfine crushing treatment: crush the crushed potato fruit into superfine powder.

[0044] Extraction and separation: take 10Kg of superfine powder, add 20L of ethyl acetate concentrated and recovered in Example 1, act under 200W ultrasound for 30 minutes at room temperature, centrifuge, and the filtrate is set aside;

[0045] The filter residue was added to 30L of the second extract in Example 1 and the concentrated and recovered ethyl acetate was refluxed successively for 1 hour each time; the first extract was combined with the ultrasonic centrifuge, concentrated until no condensed liquid dripped out, Recover the solvent for future use; the second extraction solution is then prepared to be used as the first extraction solvent for the next batch;

[0046] Add 2 times the volume of 6% TritionX-114 aqueous solution to the obtained concentrated solu...

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Abstract

The invention relates to the plant extraction field, and aims to provide an efficient and environmentally-friendly technology for extracting tabersonine from Voacanga chalotiana Pierre ex Stapf. The technology comprises the following steps: 1, taking Voacanga chalotiana Pierre ex Stapf, sun-drying, peeling shells, and crushing; 2, micronizing treatment: adding submicron powder obtained in step 1 into ethyl acetate having a volume 1.5-3 times the mass of the submicron powder, and carrying out ultrasonic treatment at normal temperature for 0.5-1h, and centrifuging; 3, carrying out reflux extraction of the filter residue obtained in step 2 for 0.5-2h twice by utilizing ethyl acetate having a volume 2-5 times the mass of the filter residue; 4, mixing the obtained reflux extract liquid with the obtained centrifugate obtained after the ultrasonic treatment, and concentrating until no droplets drop; 5, adding an aqueous solution containing 6-10% of TritonX-114 having a volume 0.5-3 times the volume of the concentrate obtained in step 4, carrying out heat insulation stirring at 35-50DEG C for 0.5-1h, and centrifuging; and 6, adding a proper amount of water to the solid obtained in step 5, stirring for 10-20min, allowing the obtained solution to stand for separating out the upper layer yellow oil, and extracting 1-3 times by using the above same method, wherein the yellow oil is liquid tabersonine. The technology has the advantages of ingenious combination, high total extraction efficiency and less pollution emission.

Description

technical field [0001] The invention relates to the field of plant extraction, and also relates to extracting tabonin, in particular to a cleaning process for extracting tabonin from potato seeds. Background technique [0002] It Boning, also known as Ta Boning, Willow Glycyrrhizin, is a monoindole alkaloid in African potato fruit (abbreviation: potato fruit), which belongs to quincaine in the alkaloids of the genus Vinca type. It has antihypertensive, antitumor, hypoglycemic, diuretic and other effects, and is used for the treatment of various diseases such as stroke sequelae, ischemic hypertensive encephalopathy, nervous tachycardia and other autonomic dysfunction. In addition, it is also widely used in the synthesis of anticancer drug vinpocetine. [0003] At present, the production of its boning is mainly chemical synthesis; or it is extracted and separated from the potato fruit, usually by drying and crushing the seeds in the potato fruit shell for extraction. Potato...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/20
CPCC07D471/20
Inventor 王龙军周晓燕陈银龙
Owner 重庆恒芯紫来科技有限公司
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