Preparation process of 2-amino-4-acetyl aminoanisole

Abstract

The invention discloses a preparation process of 2-amino-4-acetyl aminoanisole. The preparation process comprises the following steps of (1) taking methanol as a solvent and 2,4-dimitroanisole as a raw material, introducing hydrogen to perform catalytic hydrogenation reduction reaction in the presence of a catalyst; (2) performing solid-liquid separation, and recovering the catalyst; (3) adding acetic anhydride to perform acetylation reaction; (4) recovering methanol which is recycled as a solvent for follow-up hydrogenation reduction; (5) performing reduced pressure distillation to recover acetic acid; (6) performing cooling crystallization to obtain a 2-amino-4-acetyl aminoanisole product.

Description

technical field [0001] The invention relates to the field of preparation of chemicals, in particular to a preparation process of 2-amino-4-acetamidoanisole. Background technique [0002] At present, the types of disperse dyes produced in my country are relatively complete, including high-energy type, medium-energy type, fast dyeing type, etc., with more than 150 varieties, and almost all large-tonnage varieties produced abroad are produced in my country. At present, there are 7 companies with an annual output exceeding 10,000 tons, namely, disperse dark blue H-GL, disperse blue EX-SF300%, disperse ruby ​​S-2GFL, disperse yellow brown S-2RFL, disperse red 3B / FB, disperse blue 2BLN and Disperse black EX-SF300%. Even so, many dyes are subject to the production of intermediates. For example, disperse dark blue H-GL is subject to the production of raw material 2-amino-4-acetamidoanisole, which leads to high production costs and affects the competitiveness of products in the inte...

AI Technical Summary

Problems solved by technology

[0004] 2-Amino-4-acetylaminoanisole is used as a disperse dark blue H-GL intermediate. At present, there are not many domestic manufacturers and the output is very small. In the past, Zhejiang Huangyan United Chemical Plant and Jiaojiang Chemical No. 4 Plant had small-scale production facilities , it may be due to the process, and the three wastes, it is no longer produced

[0019] Both of the above two methods have the problems of complicated process, long process, a large amount of three wastes generated in the production process, many side reactions, and high impurity content in the product

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