Zhimikang expandable vaginal suppository, and preparation method and detection method thereof

A vaginal inflatable suppository and inflatable suppository technology, applied in the directions of suppository delivery, pharmaceutical formulations, material testing products, etc., can solve problems such as being difficult to clean, easy to aggregate into lumps, and reduce clinical application, so as to prevent outflow and avoid secondary infection. Effect

Active Publication Date: 2014-01-22
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zhimikang suppository is a classic Chinese patent medicine, but the water solubility of the active ingredients in the suppository is poor. In order to solve this technical problem, CN1368325 discloses a nano-Zhimikang suppository. The bioavailability of suppositories, and then obtained suppositories with good dispersibility and complete absorption, but because the particle size of each raw material medicine in the suppository is too fine after nano-processing, it is not conducive to mixing, and it is easy to aggregate into blocks, resulting in active ingredients. It has strong hygroscopicity and affects the stability of the preparation; Tian Zhenkun et al. (Tian Zhenkun, Ma Yingli, Wang Wenyi. Zhimiling Effervescent Capsule Suppository is the most useful in the treatment of phenol-induced cervical erosion model in rats[J], Journal

Method used

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  • Zhimikang expandable vaginal suppository, and preparation method and detection method thereof
  • Zhimikang expandable vaginal suppository, and preparation method and detection method thereof
  • Zhimikang expandable vaginal suppository, and preparation method and detection method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0101]

[0102] Preparation:

[0103] 1) Preparation of drug-containing matrix:

[0104] a. semi-synthetic litsea cubeba, glyceryl monostearate and yellow wax are placed in a water bath for heating and melting to obtain a melt;

[0105] b. the preparation of Chinese medicine composition:

[0106] I weigh the flavescens of the prescribed amount, crush it, add water and decoct three times, the first water consumption is 10 times the weight of Sophora flavescens, decoct for 3 hours, and the second water consumption is 10 times the weight of Sophora flavescens, decoct for 2 hours , the third water consumption is 2 times of the weight of Sophora flavescens, decoct for 1 hour, combine the decoction, filter, the filtrate is concentrated to a clear paste with a temperature of 60 °C and a relative density of 1.15; add 50% ethanol, and the amount of ethanol used is 10 times the weight of the clear paste, let it stand for precipitation, take the supernatant to recover ethanol, conce...

Embodiment 2

[0114]

[0115] Preparation method: make 100 duckbill-shaped suppositories according to the method of Example 1, each weighing about 4.6g.

Embodiment 3

[0117]

[0118] Preparation:

[0119] 1) Preparation of drug-containing matrix:

[0120] a. placing propylene glycol stearate, palm glycerin stearate and cationic emulsifying wax in a water bath for heating and melting to obtain a melt;

[0121] b. the preparation of Chinese medicine composition:

[0122] I weighed the flavescens of the prescribed amount, crushed, added water and decocted three times, the first water consumption was 15 times of the weight of flavescens, decocted for 2 hours, and the second water consumption was 5 times of the weight of flavescens, decocted for 1 hour , the third water consumption is 5 times of the weight of Sophora flavescens, decocted for 2 hours, combined the decoction, filtered, and the filtrate was concentrated to a clear paste with a temperature of 70°C and a relative density of 1.10; adding 90% ethanol, the amount of ethanol used was 5 times the weight of the clear paste, let it stand for precipitation, take the supernatant to recov...

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Abstract

The invention relates to a Zhimikang expandable vaginal suppository. The expandable suppository comprises a traditional Chinese medicine composition, a matrix and an expansion carrier. The traditional Chinese medicine composition and the matrix form a drug-containing matrix, which is coated on the surface of the carrier. The traditional Chinese medicine composition is prepared from golden cypress, sophora flavescens, catechu, dried alum and borneol. bulk drugs including cortex lycii and gentian are further required for preparation of the traditional Chinese medicine composition, and can improve treatment effect of the expandable vaginal suppository on cervical erosion and vulvovaginal candidiasis; and the traditional Chinese medicine composition is prepared into microcapsules to increase the solubility and stability of the traditional Chinese medicine composition and increase bioavailability of the suppository. The Zhimikang expandable vaginal suppository employs seven unique technologies, and has beneficial effects of prevention of outflow liquid, high stability, lasting curative effect and prevention of secondary infection.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a Zhimikang vaginal expansion suppository and a preparation method and a detection method thereof. Background technique [0002] Zhimikang Suppository, known as Zhimiling Suppository before 2010, is recorded in Volume 11 and Volume 18 of "Ministry of Health's Drug Standards for Traditional Chinese Medicine Prescriptions". Made of 20g, borneol 5g and appropriate amount of polyoxyethylene monostearate and glycerin; it was renamed as Zhimikang Suppository at the end of 2010, and it was recorded in Part One of the Chinese Pharmacopoeia 2010 Edition. It is made from 400g of dry alum, 100g of borneol, 2000-2060g of polyoxyethylene monostearate and 20ml of glycerin. The efficacy of Zhimikang Suppository has been clinically proven for many years, and it is widely used for cervical erosion, infectious vaginitis, trichomonal vaginitis and other gynecological diseases. Zhimikang suppo...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K36/815A61K47/36A61K9/02A61P15/02A61P15/00A61P31/02A61P33/02G01N33/15G01N5/04A61K33/06A61K31/045
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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