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A kind of ginkgo leaf capsule and preparation method thereof

A technology of ginkgo biloba capsules and ginkgo leaves, which is applied in the direction of capsule delivery, medical raw materials derived from ginkgo biloba, and pharmaceutical formulations, can solve the problems of easy moisture absorption of capsule particles, uneven particle color, and low clinical curative effect, and achieve solubility and Improved chemical and physical stability, less bacterial contamination, and less environmental pollution

Active Publication Date: 2016-02-17
桂林原承制药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the capsules prepared by this method are easy to absorb moisture, the color of the particles is not uniform, the difference in loading is large, and the content is unstable, so the clinical efficacy is not high, and it is not stable enough.

Method used

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  • A kind of ginkgo leaf capsule and preparation method thereof
  • A kind of ginkgo leaf capsule and preparation method thereof
  • A kind of ginkgo leaf capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A kind of ginkgo leaf capsule raw material formula of the present invention:

[0040] Ginkgo biloba extract 40g, β-cyclodextrin 150g, talcum powder 9g, magnesium stearate 1.0g.

[0041] The preparation method is as follows:

[0042] 1. Ingredients: Take 95% ethanol and prepare 25% ethanol, add 150g of β-cyclodextrin into it, stir well, make the weight ratio of β-cyclodextrin and ethanol reach 1:10, and obtain granulation spray grout.

[0043]2. Granulation: Put 40g of ginkgo leaf extract and 9g of talcum powder together in the hopper of the boiling granulation dryer, turn it on and mix well, then send the β-cyclodextrin ethanol solution spray liquid obtained in step 1) into the boiling granulation dryer. The spraying device of the granulation dryer starts spraying and granulating, so that the boiling granulation and drying can be granulated in one step, and the particle rate can reach more than 80%.

[0044] Technical parameter control: spray rate 32±2r / min, spray pr...

Embodiment 2

[0050] A kind of ginkgo leaf capsule raw material formula of the present invention:

[0051] Ginkgo biloba extract 30g, β-cyclodextrin 180g, talcum powder 7g, magnesium stearate 1.5g.

[0052] The preparation method is as follows:

[0053] 1. Ingredients: Take 95% ethanol and prepare 25% ethanol, add 180g of β-cyclodextrin into it, stir well, make the weight ratio of β-cyclodextrin and ethanol reach 3:20, and obtain granulation spray grout.

[0054] 2. Granulation: Put 30g ginkgo leaf extract and 7g talcum powder together in the hopper of the fluidized granulation dryer, turn it on and mix well, then send the β-cyclodextrin ethanol solution spray liquid obtained in step 1) into the The spraying device of the boiling granulation dryer starts spraying granulation, so that the boiling granulation drying can be granulated in one step, and the particle rate can reach 70%.

[0055] Technical parameter control: spray rate 40r / min, spray pressure 2.5×0.1Mpa; top cylinder pressure ≥...

Embodiment 3

[0061] A kind of ginkgo leaf capsule raw material formula of the present invention:

[0062] Ginkgo biloba extract 50g, β-cyclodextrin 120g, talcum powder 12g, magnesium stearate 0.5g.

[0063] The preparation method is as follows:

[0064] 1. Ingredients: Take 95% ethanol and prepare 25% ethanol, add 120g of β-cyclodextrin into it, stir well, make the weight ratio of β-cyclodextrin and ethanol reach 1:20, and obtain granulation spray grout.

[0065] 2. Granulation: Put 50g of ginkgo leaf extract and 12g of talcum powder together in the hopper of the fluidized granulation dryer, turn it on and mix well, then send the β-cyclodextrin ethanol solution spray liquid obtained in step 1) into the The spraying device of the fluidized granulation dryer starts spraying and granulating. Thus, boiling granulation and drying can be granulated in one step, and the particle rate can reach 65%.

[0066] Technical parameter control: spray rate 30r / min, spray pressure 2.5×0.1Mpa; top cylind...

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Abstract

The invention provides a ginkgo leaf capsule. The ginkgo leaf capsule comprises, by weight, 30 to 50 parts of a ginkgo leaf extract, 120 to 180 parts of beta-cyclodextrin, 7 to 12 parts of talcum powder and 0.5 to 1.5 parts of magnesium stearate. A granule is prepared from the above-mentioned raw materials and then fills a hard capsule shell so as to prepare the ginkgo leaf capsule. The ginkgo leaf capsule prepared in the invention has more stable performance and a better clinical curative effect. The invention further provides a preparation method for the ginkgo leaf capsule. The method comprises the following steps: preparing spraying slurry from beta-cyclodextrin and ethanol; subjecting the raw materials to one-step drying and granulation by using a fluid bed granulating and drying machine; and filling the obtained granule to prepare the capsule. The method can overcome disadvantages of the prior art and substantially improves bioavailability, solubility and chemical and physical stability of a drug.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a ginkgo leaf capsule and a preparation method thereof. Background technique [0002] Ginkgo biloba is a kind of medicinal material with high medicinal value. It tastes slightly bitter and flat in nature. It can benefit the heart, promote blood circulation and relieve pain, and relieve asthma. Ginkgo biloba extract is an extract processed from Ginkgo biloba leaves. It is a light brown to brown powder with a slightly bitter taste. It has been included in the 2010 edition of "Chinese Pharmacopoeia" as a standardized product and can be used as a raw material for preparation Medicines in various dosage forms, such as ginkgo leaves, ginkgo leaf capsules, pellets or soft capsules containing ginkgo leaves, etc. [0003] Ginkgo biloba capsules in the prior art have a relatively stable formula, and its functions and indications are promoting blood circulation, removing blood stasis and dre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/48A61K9/48A61K36/16A61P9/10A61P25/00A61K127/00A61K47/69
Inventor 苏建会郑湘临张志
Owner 桂林原承制药有限责任公司
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