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Nongjili base gel and preparation method thereof

A technology of Nongjili base gel and Nongjili base, which can be used in pharmaceutical formulations, aerosol delivery, medical preparations with non-active ingredients, etc. and other issues to achieve the effect of improving the quality of life

Active Publication Date: 2015-10-28
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ointments and creams tend to cause uneven coating and stain clothes; lotions and liniments are volatile and scattered, so their clinical application is limited

Method used

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  • Nongjili base gel and preparation method thereof
  • Nongjili base gel and preparation method thereof
  • Nongjili base gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1) Take Carbomer-940 5g and soak it in distilled water, and get carbomer jelly after fully swelling;

[0039] 2) Take 150ml of glycerin, 50ml of azone, and 5g of methylparaben, stir in a water bath, and mix with carbomer jelly to form a gel matrix;

[0040] 3) Take 1.2g of Nongjili alkali and dissolve it in 250ml of absolute ethanol;

[0041] 4) Slowly add the medicinal solution obtained in step 3) into the gel matrix obtained in step 2) and mix well;

[0042] 5) Use triethanolamine to adjust the pH value of the gel to neutral, and add distilled water while stirring to a sufficient amount of 1000g to obtain Nongjili base gel.

Embodiment 2

[0044] 1) Take 10g of Carbomer-940 and soak it in distilled water, and get carbomer jelly after fully swelling;

[0045] 2) Take 100ml of glycerin, 25ml of azone, and 10g of methylparaben, stir in a water bath, and mix with carbomer jelly to form a gel matrix;

[0046] 3) Take 1.2g of Nongjili base and dissolve it in 200ml of absolute ethanol;

[0047] 4) Slowly add the medicinal solution obtained in step 3) into the gel matrix obtained in step 2) and mix well;

[0048] 5) Use triethanolamine to adjust the pH value of the gel to neutral, and add distilled water while stirring to a sufficient amount of 1000g to obtain Nongjili base gel.

Embodiment 3

[0050] 1) Take 8g of Carbomer-940 and soak it in distilled water, and get carbomer jelly after fully swelling;

[0051] 2) Take 50ml of glycerin, 10ml of azone, and 8g of methylparaben, stir on a water bath, and mix with carbomer jelly to form a gel matrix;

[0052] 3) Take 1.2g of Nongjili alkali and dissolve it in 300ml of absolute ethanol;

[0053] 4) Slowly add the medicinal solution obtained in step 3) into the gel matrix obtained in step 2) and mix well;

[0054] 5) Use triethanolamine to adjust the pH value of the gel to neutral, and add distilled water while stirring to a sufficient amount of 1000g to obtain Nongjili base gel.

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Abstract

The invention provides a monocrotaline gel and a preparation method thereof, belonging to the technical field of monocrotaline preparations. Each kg of the gel comprises 1.2 g of monocrotaline, 5 to 10 g of carbomer-940, 50 to 150 ml of glycerin, 10 to 50 ml of azone, 200 to 300 ml of absolute ethyl alcohol and 5 to 10 g of methylparaben, with the balance being distilled water, and triethanolamine is used to adjust a pH value to neutral. According to the invention, the gel is prepared from monocrotaline and used for treating squamous-cell carcinoma, and the gel can avoid toxic and side effects on the whole body caused by oral administration or intravenous injection and intramuscular injection and achieves the purposes of local treatment of diseases and improvement of living quality of patients; furthermore, through single factor investigation and orthogonal design, accessories for the gel are screened, which enables monocrotaline to be more stable and to better perform its effects.

Description

technical field [0001] The invention belongs to the technical field of Nongjili base preparations, and in particular relates to Nongjili base gel and a preparation method thereof. Background technique [0002] Monocrotaline (Crotaline), also known as monocrotaline, crotaline, also known as monocrotaline, crotaline, crotaline, crotaline, is commonly used in clinical practice, with many experimental studies and relatively thorough research. Anticancer traditional Chinese medicine ingredient, the molecular formula is C 16 h 23 NO 6 , is similar in structure to N-O-nortianaline (indicine-N-oxide, III), which has entered phase II clinical trials in the United States, and is also a double-condensed pyrrolizidine alkloids (Pas). It is an active alkylating component, which can interfere with cell mitosis and has anti-tumor effect. Nongjili base has inhibitory effect on a variety of experimental tumors, and it is mainly used in SCC and BCC in clinical trials, with definite curati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/407A61K47/32A61K47/10A61K47/22A61P35/00
Inventor 黄绳武王俊俊蒋杉杉赵丹丹李雅雅章德军
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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