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Avermectin and griseofulvin composite pesticidal nanoemulsion

A technology of griseofulvin and abamectin, applied in the direction of insecticides, biocides, acaricides, etc., can solve the problems that pests are difficult to absorb and the duration of killing is short, and achieve strong and long-lasting effects Long-term, drug-stable effect

Active Publication Date: 2014-01-01
JIANGSU ESSENCE AGROCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some antibiotic drugs are poorly soluble drugs, which are difficult to absorb when entering the pest body, and the killing duration is short, which requires the application of modern pharmacy principles to design new dosage forms

Method used

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  • Avermectin and griseofulvin composite pesticidal nanoemulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Recipe: 10 parts of abamectin, 10 parts of griseofulvin, 150 parts of ethyl oleate, 30 parts of albumin, 12 parts of n-butanol.

[0019] The preparation method of the above-mentioned abamectin and griseofulvin composite nanoemulsion insecticide includes the following steps:

[0020] (1) Add abamectin, griseofulvin and albumin to ethyl oleate to obtain an oil phase solution;

[0021] (2) Under stirring conditions, add the above-mentioned oil phase solution to water to obtain an oil-water mixture;

[0022] (3) Add n-butanol to water, slowly drop it into the above-mentioned oil-water mixture at a temperature of 35°C, until the solution is transparent, to obtain an oil-in-water nanoemulsion.

[0023] The abamectin and griseofulvin composite nanoemulsion insecticide prepared in this example has the characteristics of stable drug, strong drug effect and long lasting effect, and has gastric toxicity and contact killing effects on mites and insects.

Embodiment 2

[0025] Recipe: 10 parts of abamectin, 5 parts of griseofulvin, 100 parts of soybean oil, 10 parts of soybean phospholipids, 10 parts of lecithin, 10 parts of ethylene glycol.

[0026] The preparation method of the above-mentioned abamectin and griseofulvin composite nanoemulsion insecticide includes the following steps:

[0027] (1) Add abamectin, griseofulvin, soybean phospholipid and lecithin to soybean oil to obtain an oil phase solution;

[0028] (2) Under stirring conditions, add the above-mentioned oil phase solution to water to obtain an oil-water mixture;

[0029] (3) Add ethylene glycol to the water, slowly drop it into the above-mentioned oil-water mixture, at a temperature of 30°C, until the solution is transparent, to obtain an oil-in-water nanoemulsion.

[0030] The abamectin and griseofulvin composite nanoemulsion insecticide prepared in this example has the characteristics of stable drug, strong drug effect and long lasting effect, and has gastric toxicity and contact kil...

Embodiment 3

[0032] Recipe: 10 parts of abamectin, 15 parts of griseofulvin, 200 parts of liquid paraffin, 10 parts of albumin, 30 parts of lecithin, 15 parts of ethanol and n-butanol.

[0033] The preparation method of the above-mentioned abamectin and griseofulvin composite nanoemulsion insecticide includes the following steps:

[0034] (1) Add abamectin, griseofulvin, albumin and lecithin to liquid paraffin to obtain an oil phase solution;

[0035] (2) Under stirring conditions, add the above-mentioned oil phase solution to water to obtain an oil-water mixture;

[0036] (3) Add ethanol and n-butanol to water, slowly drop them into the above-mentioned oil-water mixture at a temperature of 40°C, until the solution is transparent, to obtain an oil-in-water nanoemulsion.

[0037] The abamectin and griseofulvin composite nanoemulsion insecticide prepared in this example has the characteristics of stable drug, strong drug effect and long lasting effect, and has gastric toxicity and contact killing effe...

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Abstract

The invention discloses an avermectin and griseofulvin composite pesticidal nanoemulsion. The avermectin and griseofulvin composite pesticidal nanoemulsion is mainly prepared from the following components: 10 parts of avermectin, 5-15 parts of griseofulvin, 100-200 parts of oil phase, 20-40 parts of emulsifier and 10-15 parts of coemulsifier. Compared with the prior art, the prepared avermectin and griseofulvin composite pesticidal nanoemulsionhas the characteristics of drug stability, strong efficacy and long duration, has stomach-poisoning and contact-killing effects on mites and insects, is mainly applicable to internal and external parasites of poultry and livestock as well as crop pests, and can control a variety of pests on citrus, forest trees, cotton, vegetables, tobacco, rice and other crops, such as parasitic bloodworms, diptera, coleoptera, lepidoptera, harmful mites and the like.

Description

Technical field [0001] The invention relates to a biological pesticide, in particular to an abamectin and griseofulvin composite nanoemulsion insecticide, which is applied in the agricultural field. Background technique [0002] Biological pesticides refer to living organisms and their metabolites and genetically modified products used to control diseases, insects, weeds and other harmful organisms, and can be made into commercial biological preparations, including bacteria, viruses, fungi, nematodes, plants, natural enemies of insects, Agricultural antibiotics, plant growth regulators, and genetically modified plants resistant to pests and diseases. Biological pesticides have been used in agricultural production for half a century, but the development has been relatively slow due to various reasons. In recent years, people have paid more and more attention to the sustainable development of agricultural production and the coordination between people and the environment. Especial...

Claims

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Application Information

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IPC IPC(8): A01N43/90A01N25/04A01P7/02A01P7/04A61K31/7048A61K9/107A61P33/14A61P31/22A61K31/343A01N43/12
Inventor 卞佳林
Owner JIANGSU ESSENCE AGROCHEM
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