Application of lycojaponicumin B in preparation of medicine for treating hemorrhagic fever with renal syndrome

A technology for renal syndrome and hemorrhagic fever, which can be used in drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve problems such as uncertain effects, and achieve strong viral inhibitory activity and outstanding essence in hemorrhagic fever with renal syndrome. effects of sexuality

Inactive Publication Date: 2015-11-25
付海柱
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antiviral treatments such as ribavirin and interferon are often used clinically, but the effect is not yet certain

Method used

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  • Application of lycojaponicumin B in preparation of medicine for treating hemorrhagic fever with renal syndrome
  • Application of lycojaponicumin B in preparation of medicine for treating hemorrhagic fever with renal syndrome
  • Application of lycojaponicumin B in preparation of medicine for treating hemorrhagic fever with renal syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound LycojaponicuminB tablet involved in the present invention:

[0013] Take 20 grams of compound Lycojaponicumin B, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press machine.

Embodiment 2

[0014] Embodiment 2: the preparation of compound LycojaponicuminB capsules involved in the present invention:

[0015] Get 20 grams of compound Lycojaponicumin B, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

[0017] In order to better understand the essence of the present invention, the following experimental research results of LycojaponicuminB will illustrate its application in the field of pharmacy.

[0018] The specific experiment is as follows:

[0019] 1. Experimental study of LycojaponicuminB against hemorrhagic fever with renal syndrome virus

[0020] (1) In vitro inhibition experiment on hemorrhagic fever with renal syndrome virus

[0021] 1 material

[0022] (1) Virus strain: the international standard strain of hemorrhagic fever with renal syndrome virus 76-118, which is ...

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Abstract

The invention discloses a new application of Lycojaponicumin B in preparation of a medicine for treating hemorrhagic fever with renal syndrome. Experimental researches of the Lycojaponicumin B in-vitro and in-vivo inhibition on virus of hemorrhagic fever with renal syndrome indicate that the Lycojaponicumin B has low toxicity to cells, can directly kill the virus of hemorrhagic fever with renal syndrome, can remarkably inhibit multiplication of the virus, and can obviously protect shrewmouse infected by the virus so as to delay the disease time, prolong the course of disease and reduce the death rate. Therefore, the Lycojaponicumin B is an effective and safe medicine for treating hemorrhagic fever with renal syndrome.

Description

technical field [0001] The present invention relates to the use of Lycojaponicumin B, in particular to the use of Lycojaponicumin B in the pharmaceutical field. Background technique [0002] There are 13 kinds of human viral hemorrhagic fever in the world. According to whether the disease has kidney damage, it is divided into two categories: with kidney damage and without kidney damage. In my country, it is mainly hemorrhagic fever with renal syndrome (HFRS), also known as epidemic hemorrhagic fever. It is called Korean hemorrhagic fever (KHF) in North Korea; it is called hemorrhagic nephropathy nephritis (HNN) in the Soviet Union; due to the establishment of specific serological diagnosis and the resolution of etiology, the World Health Organization uniformly named it renal syndrome in 1982 Symptoms of hemorrhagic fever. [0003] The disease is caused by Korean hemorrhagic fever virus (or Hantaan virus), a natural foci disease with rodents as the main source of infection; it...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/424A61P13/12A61P31/14
Inventor 江春平张广
Owner 付海柱
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