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Agent for alleviating delayed hypersensitivity

A technique for allergy and hairstyle, applied in application, allergic diseases, medical raw materials derived from bacteria, etc.

Active Publication Date: 2013-12-18
MEIJI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, there is no report on the reduction of delayed hypersensitivity reaction or the suppression of delayed hypersensitivity reaction by microorganisms such as lactic acid bacteria

Method used

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  • Agent for alleviating delayed hypersensitivity
  • Agent for alleviating delayed hypersensitivity
  • Agent for alleviating delayed hypersensitivity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0093] Suppression of splenic CD4 + The effect of the proliferative response of T cells

[0094] 1. Materials and methods

[0095] 〔animal〕

[0096] Female BALB / c mice aged 8-10 weeks were purchased from CLEA, Japan. 8-10 weeks-old female DO11.10TCR transgenic mice express I-A specific for 323-339 positions of ovalbumin (OVA) d Mice restricted to the T cell receptor (TCR) αβ chain (derived from BALB / c mice).

[0097] 〔Preparation of heat-treated bacterial suspension and its fractions〕

[0098] The heat-treated bacteria (3 mg in terms of dry weight) were collected by centrifugation and suspended in physiological saline at a concentration of 5 mg / ml. 0.5 g of glass beads (0.1 mm in diameter, Sigma-Aldrich, St. Louis, MO) were added to the cell suspension, and crushed with a Multi-beads shocker (Yasui Machinery) to obtain a crushed cell liquid. The pulverized liquid was centrifuged at 300×g for 10 minutes at 4°C, and fractionated into a supernatant and a precipitate ...

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PUM

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Abstract

It was revealed that a cell fraction of Lactobacillus gasseri, which has been eaten, and the safety of long-term ingestion of which has been ensured, suppresses a delayed hypersensitive reaction. Therefore, the invention provides an agent for alleviating delayed hypersensitivity containing a cell fraction of Lactobacillus gasseri. Further, the invention provides a food composition for alleviating delayed hypersensitivity containing the cell fraction of Lactobacillus gasseri. In the invention, it was revealed that an RNA fraction of the cell fraction has a particularly high effect of suppressing a delayed hypersensitive reaction.

Description

technical field [0001] The present invention relates to a drug for alleviating delayed hypersensitivity, a food composition for alleviating delayed hypersensitivity containing the same, and the like. Background technique [0002] Anaphylaxis, that is, allergic diseases, is classified into types I to IV, and their respective pathogenesis and symptoms are different. In type I allergy, antigen-specific IgE is induced due to antigen sensitization, and the produced IgE binds to the surface of mast cells. There, when the antigen invaded into the body is captured by the specific IgE, chemical mediators such as histamine are secreted by mast cells. As a result, increased vascular permeability, bronchoconstriction, and immediate allergic reactions such as sneezing and nasal discharge are caused. [0003] On the other hand, type IV allergy is a disease caused by a delayed hypersensitivity reaction, and is a disease in which antigen-specific T cells activate macrophages and the like ...

Claims

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Application Information

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IPC IPC(8): A61K35/74A23C9/12A23C9/152A23L1/30A61P37/08A61K35/747
CPCA23C9/1234A61K35/747A23L33/135A61P37/08A61P43/00A23V2400/145
Inventor 指原纪宏池上秀二户塚护吉田绫子清水诚
Owner MEIJI CO LTD
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