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Anti-infection material for intrauterine contraceptive device and preparation method of anti-infection material

An IUD and anti-infection technology, which is applied in the fields of medical science and surgery, can solve the problems that polymer material parts are easy to adhere to bacteria, polymer parts do not have anti-infection, and form infection sources, so as to reduce the phenomenon of uterine inflammation and Its secretion, improve anti-infection performance, improve the effect of tissue compatibility

Active Publication Date: 2013-12-18
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although metal copper is an excellent contraceptive substance and anti-infection element, polymer parts do not have anti-infection properties. At the same time, other additives are added to the polymer material during processing, which makes the polymer material parts easy to adhere to bacteria and cause infection. source

Method used

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  • Anti-infection material for intrauterine contraceptive device and preparation method of anti-infection material
  • Anti-infection material for intrauterine contraceptive device and preparation method of anti-infection material
  • Anti-infection material for intrauterine contraceptive device and preparation method of anti-infection material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Weigh 1.0kg of chitosan with a degree of deacetylation of 50%, dissolve it in a dilute hydrochloric acid solution with a pH of 1.0, make it fully dissolved, then add 0.01kg of anhydrous copper sulfate, stir it fully to make it fully dissolve in the shell Form chitosan complex in polysaccharide hydrochloric acid solution, then add 1.0mol / L sodium hydroxide solution to precipitate chitosan complex, wash with deionized water, dry under reduced pressure or hot air, pulverize, and finally form a powder Chitosan complexes such as figure 1 shown.

[0032] 0.6kg of the above-mentioned powdered chitosan compound and 1.0kg of low-density polyethylene are physically mixed, and the mixture is melt-blended through a twin-screw extruder to prepare a uniformly mixed low-density polyethylene material containing the chitosan compound , and then injection molded into T-shaped polymer parts for TCuIUD, such as figure 2 As shown, the polymer component has excellent antibacterial propert...

Embodiment 2

[0034] Weigh 1.0kg of chitosan with a degree of deacetylation of 100%, dissolve it in a dilute hydrochloric acid solution with a pH of 5.0, make it fully dissolved, then add 2.0kg of anhydrous copper sulfate, stir it fully to make it fully dissolve in the shell Chitosan complexes are formed in the polysaccharide hydrochloric acid solution, and the chitosan complexes are obtained after solution extrusion molding, no problem washing with 1.0mol / L sodium hydroxide solution, deionized water washing, and shearing, and decompression Or hot air drying, and finally form a fibrous chitosan complex, such as Figure 4 shown.

[0035] 1.0kg of the above-mentioned fibrous chitosan compound and 0.7kg of low-density polyethylene are physically mixed, and the mixture is melt-blended through a twin-screw extruder to prepare a uniformly mixed low-density polyethylene containing chitosan compound The material is then injection molded into a T-shaped polymer part for TCuIUD. The polymer part has...

Embodiment 3

[0037] Weigh 1.0kg of chitosan with a degree of deacetylation of 50%, dissolve it in a dilute hydrochloric acid solution with a pH of 5.0, make it fully dissolved, then add 0.5kg of silver nitrate, stir it fully to make it fully dissolve in chitosan Form chitosan complex in hydrochloric acid solution, then add 1.0mol / L sodium hydroxide solution to precipitate chitosan complex, wash with deionized water, dry and pulverize under reduced pressure or hot air, and finally form powdered chitosan sugar complexes.

[0038]0.01kg of the above powdered chitosan compound and 1.0kg of low-density polyethylene are physically mixed, and the mixture is melt-blended through a twin-screw extruder to prepare a uniformly mixed low-density polyethylene material containing the chitosan compound , and then injection molded into a T-shaped polymer part for TCuIUD. The polymer part has excellent antibacterial properties, and the antibacterial rate against Candida albicans reaches 99%, thereby improvi...

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Abstract

The invention discloses an anti-infection material for an intrauterine contraceptive device. The material is prepared by uniformly mixing a chitosan composite material and a high polymer material, the weight ratio of the chitosan composite material to the high polymer material is 0.01%-60%. The intrauterine contraceptive device prepared from the anti-infection material is good in tissue compatibility and capable of inhibiting the colonization and growth of bacterial on a surface of the intrauterine contraceptive device so as to reduce the inflammation.

Description

technical field [0001] The invention relates to the field of medical device materials, in particular to an anti-infection material used for birth control devices and a preparation method thereof. Background technique [0002] Intrauterine device (IUD) is a safe, effective and reversible method of contraception. There are 80 million women in the world using IUD, and it is the most widely used in my country, accounting for 39.1% of all kinds of contraceptive measures used by women of childbearing age in my country. Because the copper-containing IUD has a good contraceptive effect and is cheap, the IUDs currently used in my country are mainly copper-containing IUDs, such as TCuIUD. Even so, the TCuIUD still cannot get rid of side effects such as pain, bleeding, and inflammation. Changes in the bleeding pattern after IUD placement, such as heavy menstrual flow, prolonged menstrual periods, or irregular bleeding, are the most common reasons for IUD removal due to symptoms. [00...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/06A61L31/16
Inventor 张维季君晖钱越英
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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