Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cefaclor capsule and preparation method thereof

A technology of Cefaclor capsules and Cefaclor, which is applied in the field of medicine and can solve problems such as delamination, unstable quality of cefaclor raw materials, and poor quality stability of cefaclor preparations.

Active Publication Date: 2013-12-18
回音必集团浙江齐齐制药有限公司
View PDF2 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The quality of cefaclor raw materials is unstable and easy to degrade under humid and hot conditions. Therefore, the quality stability of cefaclor preparations currently on the market is generally poor, and the preparations need to be kept away from light and sealed.
In addition, because cefaclor is slightly soluble in water, the capsules usually have the problem of poor suspending effect. After adding a certain amount of water to dissolve, the solution suspending effect is poor and stratification occurs. It is difficult to ensure the dosage when taking. affect the efficacy of the drug

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cefaclor capsule and preparation method thereof
  • Cefaclor capsule and preparation method thereof
  • Cefaclor capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018]

[0019]

[0020] Preparation Process:

[0021] Pass cefaclor through a 100 mesh sieve, dissolve Kollicoat IR (3:1) in absolute ethanol, add cefaclor, stir evenly and dry under reduced pressure to remove ethanol, mix the dried granules with sucrose passed through a 100 mesh sieve evenly , packed in capsules.

Embodiment 2

[0023]

[0024] Preparation Process:

[0025] Pass cefaclor through a 100 mesh sieve, dissolve Kollicoat IR (3:1) in absolute ethanol, add cefaclor, stir evenly and dry under reduced pressure to remove ethanol, mix the dried granules with mannitol, The lactose is mixed evenly, filled into capsules and packaged.

Embodiment 3

[0027]

[0028] Preparation Process:

[0029] Pass cefaclor through a 100-mesh sieve, dissolve Kollicoat IR (3:1) in absolute ethanol, add cefaclor, stir evenly and dry under reduced pressure to remove ethanol, mix the dried granules with mannitol and sucrose evenly, pour Capsule packaging. Comparative Example 1

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a cefaclor capsule and a preparation method thereof. The preparation is obtained by mixing a cefaclor inclusion complex and pharmaceutically acceptable auxiliary materials. The preparation method of the cefaclor inclusion complex comprises the following steps: dissolving polyvinyl alcohol-polyethylene glycol grafted copolymer (Kollicoat IR) in ethyl alcohol, adding cefaclor, carrying out reduced-pressure drying for removing ethyl alcohol while stirring, and filing into capsules, thus obtaining the cefaclor capsules. The cefaclor capsule is good in stability, high in dissolve-out speed, simple in production technique, and suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a cefaclor capsule and a preparation method thereof. Background technique [0002] Cephalosporins play a bactericidal effect by inhibiting bacterial cell wall synthesis and are stable to most β-lactamases. Many strains producing penicillinase and cephalosporinase are still sensitive to cephalosporins. Cephalosporins in vitro and in vivo against Gram-positive cocci such as pneumococcus, Streptococcus pyogenes, Gram-negative bacilli such as influenza bacilli (including enzyme-producing strains), Moraxella catarrhalis (including enzyme-producing strains) , Escherichia coli, Proteus mirabilis, and Neisseria gonorrhoeae (including enzyme-producing strains) all have good antibacterial effects. Effects of cephalosporins on Streptococcus pneumoniae, Bacillus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Pasteurella multocida, Providencia sp., Salmonella sp., Shig...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/48A61K31/545A61K47/48A61P31/04
Inventor 不公告发明人
Owner 回音必集团浙江齐齐制药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com