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Method for preparing nano drug-carrying capsule-loaded alginate fibers

A technology of nano-drug loading and seaweed fiber, which is applied in the direction of capsule delivery, microcapsules, nanocapsules, etc., can solve the problems of single drug properties and low effective load, so as to expand the application field, reduce wound infection, and reduce the cost of drugs. churn effect

Active Publication Date: 2013-12-11
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a preparation method of seaweed fiber loaded with nano drug-loaded capsules, on the basis of the original excellent performance of seaweed fiber, endow it with new functional activity, and solve the drug payload of the existing drug-loaded fiber Low, single nature of the drug and other issues

Method used

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  • Method for preparing nano drug-carrying capsule-loaded alginate fibers

Examples

Experimental program
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Effect test

Embodiment 1

[0019] (1) Weigh 10 g of sodium alginate and add it to 750 mL of deionized water, stir in a water bath at 50 °C for 30 min to obtain a uniform sodium alginate solution; add 0.02 mol / L of Ca(OH) dropwise successively 2 solution and 0.03 mol / L NaHCO 3 Each solution was 200 mL, and stirred for 1 h in a constant temperature water bath at 50 °C; 200 mL of 200 μg / mL vancomycin hydrochloride aqueous solution was added, and stirred for 2 h in a constant temperature water bath at 50 °C; the mixed solution was placed in an ice water bath, and stood for 24 h , centrifuged at 12000 rpm and washed three times with water, and finally freeze-dried to obtain calcium alginate nanocapsules loaded with vancomycin hydrochloride, with a drug loading capacity of 23%.

[0020] (2) Weigh 10 g of sodium alginate and add it to 275 mL of deionized water, stir and dissolve fully to obtain a sodium alginate solution with a mass concentration of 3.5 %; weigh 0.1 g of calcium alginate nanocapsules loaded wi...

Embodiment 2

[0022] (1) Weigh 10 g of sodium alginate and add it to 750 mL of deionized water, stir in a water bath at 50 °C for 30 min to obtain a uniform sodium alginate solution; add 0.02 mol / L of Ca(OH) dropwise successively 2 solution and 0.03 mol / L NaHCO 3 Each solution was 200 mL, and stirred for 1 h in a constant temperature water bath at 50 °C; 200 mL of 200 μg / mL ibuprofen solution was added, and stirred for 2 h in a constant temperature water bath at 50 °C to disperse evenly; the mixed solution was placed in an ice water bath, and stood for 24 h, centrifuged at 12000 rpm and washed three times with water, and finally freeze-dried to obtain calcium alginate nanocapsules loaded with ibuprofen, with a drug loading capacity of 36%.

[0023] (2) Weigh 10 g of sodium alginate and add it to 275 mL of deionized water, fully stir and dissolve to obtain a sodium alginate solution with a mass concentration of 3.5 %; weigh 1.5 g of calcium alginate nanocapsules loaded with ibuprofen, add i...

Embodiment 3

[0025] (1) Weigh 10 g of sodium alginate and add it to 750 mL of deionized water, stir in a water bath at 50 °C for 30 min to obtain a uniform sodium alginate solution; add 0.02 mol / L of Ca(OH) dropwise successively 2 solution and 0.03 mol / L NaHCO 3 Each solution was 200 mL, and stirred in a constant temperature water bath at 50 °C for 1 h; adding 100 mL of 200 μg / mL ibuprofen solution, stirred in a constant temperature water bath at 50 °C for 1 h, and then added 100 mL of 200 μg / mL vancomycin hydrochloride , and continue stirring for 1 h; the mixture was placed in an ice-water bath, allowed to stand for 24 h, centrifuged at 12,000 rpm and washed three times with water, and finally freeze-dried to obtain calcium alginate nanocapsules loaded with ibuprofen and vancomycin hydrochloride at the same time. The ibuprofen loading was 31%, and the vancomycin hydrochloride loading was 18%.

[0026] (2) Weigh 10.0 g of sodium alginate and add it to 275 mL of deionized water, stir and d...

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Abstract

The invention discloses a method for preparing nano drug-carrying capsule-loaded alginate fibers. The method comprises the steps of preparing a nano drug-carrying capsule by taking sodium alginate as a matrix; adding the nano drug-carrying capsule in a sodium alginate spinning solution; and preparing nano drug-carrying capsule-loaded alginate fibers through wet spinning. According to the method, the loss of drugs in the spinning process can be reduced, and because a drug is wrapped in the capsule, so that the drug can be effectively prevented from degenerating, and different kinds of drugs can be loaded in the capsule. In addition, the capsule is prepared by taking sodium alginate as the matrix, compared with homogeneous fibers, the alginate fibers have good interface compatibility, and the drug-carrying capsule is in nanoscale, does not affect the spinnability and the final fiber performances of the sodium alginate spinning solution. The method disclosed by the invention can be applied to medical materials such as dressings, gauzes, bandages, drug patches, drug pads and the like, and achieves the effects of reducing wound infection and inflammation possibility, stimulating cell proliferation and implementing other actions so as to accelerate wound healing; the method is also applied to the local chemotherapy after tumor surgeries.

Description

technical field [0001] The invention relates to a method for preparing functional fibers, in particular to a method for preparing seaweed fibers loaded with nano drug-loaded capsules. Background technique [0002] Seaweed fiber is made of sodium alginate extracted from marine brown algae plants, using a solution containing divalent metal cations (except magnesium ions, generally calcium ions) as a coagulation bath, and processed by wet spinning technology A recycled fiber. Seaweed fiber has excellent characteristics such as high hygroscopic gelation, overall easy removal, high oxygen permeability, biocompatibility, and biodegradable absorption. In addition, after seaweed fibers come into contact with wound exudate or blood, Na + / Ca 2+ Ion exchange, releasing Ca 2+ , Accelerate the blood coagulation process, and at the same time form a layer of stable mesh gel on the surface of the wound, create a microenvironment for the wound that is conducive to tissue growth (slightl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F9/04D01F1/10A61L15/28A61L15/44A61K45/00A61K9/51A61K47/36
Inventor 姚菊明许国凯刘琳
Owner ZHEJIANG SCI-TECH UNIV
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