Preparation method of gluconic acid and glucaric acid

Abstract

The invention discloses a preparation method of gluconic acid and glucaric acid in the technical field of organic electrochemistry synthesis. The preparation method comprises the steps that an electro-catalytic membrane serving as an anode and an auxiliary electrode serving as a cathode are connected with a voltage-stabilized source by wires to form an electro-catalytic membrane reactor; by taking a glucose aqueous solution as a reactant, and an inorganic substance as an electrolyte, gluconic acid and glucaric acid are prepared by catalytic oxidation of glucose with the electro-catalytic membrane under the action of an electric field; membrane penetration liquid is collected by suction of a peristaltic pump; obtained target products are separated from reaction liquid in real time by permeation of the membrane; the membrane penetration liquid is separated and purified to form gluconic acid and glucaric acid products; and yields of gluconic acid and glucaric acid are adjusted and controlled by adjusting and controlling current density and membrane flux. The preparation method integrates catalytic oxidation and separation functions, and can separate the obtained target products from the reaction liquid timely, so that the continuous high efficiency of the electro-catalytic membrane is maintained effectively; a side reaction is avoided; and the selectivity of the target products is improved.

Description

Technical field [0001] The invention belongs to the technical field of organic electrochemical synthesis, and particularly relates to a method for preparing gluconic acid and glucaric acid. Background technique [0002] D-gluconic acid (D-gluconic acid) is an important intermediate for products in the chemical, food, pharmaceutical, light industry and other industries, and has a very broad application prospect. The current world output of gluconic acid exceeds 100,000 tons per year. As a high value-added organic acid, gluconic acid is usually produced by oxidation of glucose, the most abundant monosaccharide in nature. Among them, the fermentation oxidation method is the main route for the industrial preparation of gluconic acid and the reaction equation is as follows: [0003] [0004] The method uses biological enzymes to oxidize glucose to prepare gluconic acid, without adding other oxidants that are harmful to the environment, and the production cost is low. However, this me...

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Problems solved by technology

Even so, there are still some shortcomings in organic electrochemical synthesis: (1) Electrochemical synthesis cannot separate reactants and products in time after the reaction, which will lead to further oxidation of products and other side reactions, which will eventually affect the reaction. Selectivity and yield of the target product; (2) The reactant can only rely on the electric field to transfer from the solution body to the electrode surface, and then the electrochemical reaction occurs, and the product cannot leave the electrode surface in time after the reaction, thus hindering the new process. The progress of the reaction

However, the inventive method only provides a method for preparing aldehydes or acids by oxidation of small molecule alcohols, and does not involve specific information on electrocatalytic membranes, nor does it involve the regulation of product aldehyde and acid yields during the preparation process

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