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Traditional Chinese medicine effective part composition for treating schizophrenia and preparation method thereof

A technology for schizophrenia and effective parts, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve problems such as chronic decline, protracted disease course, and high recurrence rate, and achieve non-toxic side effects and high yield High and maintain the effect of active ingredients

Inactive Publication Date: 2013-12-11
广州市云桥生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the recurrence rate of this disease is relatively high, and some patients have a prolonged course of disease and may develop into a chronic decline state.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take 25g of lotus seeds, 29g of Sichuan Achyranthes bidentata, 18g of bamboo ginseng, 18g of musk shell and 10g of castor bean, grind them into coarse powder, add 12 times the amount of water, decoct 3 times, each time for 1 hour; filter the decoction and combine The filtrate was concentrated under reduced pressure to a paste with a relative concentration of 1.14, and ethanol was added to make the alcohol content 69%, and it was allowed to stand overnight, and the ethanol was recovered to obtain 1000ml of the concentrated solution. Adjust the pH to 4, add distilled water to 5000ml, stir evenly, filter and pack into 15ml glass bottles, and pack to obtain oral liquid.

[0019] This product is a yellow-brown clear liquid, which will not become turbid within half a year, with a pH of about 4 and a total solid of about 9%.

Embodiment 2

[0021] 200 patients were clinically observed, all of whom had obvious clinical symptoms of schizophrenia and were diagnosed by clinicians.

[0022] Oral the oral liquid that embodiment 1 makes, every day 2 times, each 15ml. Medication time is 30 days.

[0023] After 30 days, the statistical results of patients using the oral liquid obtained in Example 1 are shown in Table 1.

[0024] Efficacy standard: Marked effect includes recovery and improvement, among which, recovery refers to the disappearance of symptoms, recovery of insight, good response to the surrounding environment, and recovery of work, study and living ability before the disease; improvement refers to the basic disappearance of symptoms of the patient, self-knowledge Most of the strength recovered, and the ability to work and study before the illness was basically restored. Ineffective means no improvement or even worsening of symptoms.

[0025] Table 1

[0026] Number of cases markedly effective ...

Embodiment 3

[0029] The oral liquid prepared in Example 1 was used to administer ICR mice with a body weight of 20-25 g, half male and half male, and the administration was continued for 90 days.

[0030] After pre-testing, the toxicity of the lotion prepared in Example 1 was very low, and the LD50 could not be measured, so the maximum daily dosage was determined for mice. The maximum dosage is 150ml / d. After 90 days, there is no case of poisoning death, and all of them are alive and healthy. This proves that the oral liquid made from the composition of the present invention will not cause toxic and side effects to the human body.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine effective part composition for treating schizophrenia and a preparation method thereof. The traditional Chinese medicine effective part composition is prepared by the following raw materials in parts by weight: lotus seeds, cyathula officinalis, panax japonicus, musk deer glandular sac wall and castor bean. The traditional Chinese medicine effective part composition provided by the invention can be prepared into medicine for treating schizophrenia, and has effects of clearing heat and resolving phlegm, calming liver and stabilizing mind state, dissipating phlegm for resuscitation, restoring consciousness and calming mind, activating blood and dissolving stasis, nourishing Yin and purging fire, and warming kidney and strengthening spleen, can be used for treating schizophrenia obviously, and has the advantages of no toxicity or side effects, and high security.

Description

Technical field [0001] The invention involves the field of traditional Chinese medicine compositions, which specifically involves a composition and preparation method for the treatment of Chinese medicine for the treatment of schizophrenia. Background technique [0002] Schizophrenia is the most common of various mental illness.It is the main clinical characteristics based on the basic personality changes, the division of thinking, emotion, and behavior.At present, the etiology and pathogenesis of schizophrenia have not been clarified, and there are no special treatment methods.Modern Western Medicine's common treatment methods are anti -psychiatric drugs, insulin shock, electric shock and mental treatment.However, the recurrence rate of this disease is high, and some patients have a delay in disease, which can develop into a state of chronic recession. Invention content [0003] The purpose of the present invention is to provide a composition for the effective parts of traditio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/62A61P25/18A61K35/55
Inventor 张群
Owner 广州市云桥生物科技有限公司
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