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Polysaccharide compound for preventing and treating porcine diarrhea and application thereof

A compound agent and porcine diarrhea technology, applied in the direction of medical preparations containing active ingredients, drug combinations, antiviral agents, etc., can solve the problem of sulfated polysaccharides having no antibacterial activity

Active Publication Date: 2013-12-11
福建九为生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Guo Ling et al. (2002) found that the unhydrolyzed sulfated polysaccharide had no antibacterial activity through the study of the antibacterial activity of Eucheuma sulfate polysaccharide and its acid hydrolysis products.

Method used

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  • Polysaccharide compound for preventing and treating porcine diarrhea and application thereof
  • Polysaccharide compound for preventing and treating porcine diarrhea and application thereof
  • Polysaccharide compound for preventing and treating porcine diarrhea and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Prepare according to the proportioning in Table 1.

[0044] The preparation method of oligomeric fucoidan is:

[0045] Extraction: 80-mesh kelp powder was added to deionized water at a ratio of 1:25 (w / v), extracted at 80 °C for 3 h, stirring continuously during the extraction process, the stirring speed was 2000 r / min, centrifuged (3000 r / min, 10 min), take the supernatant, add HCl (12 mol / L) to make the final concentration 0.1 mol / L; then centrifuge (3000 r / min, 5 min), remove the alginic acid precipitate, collect the supernatant, add Water and ethanol to make the final concentration of 30% (v / v), overnight; centrifuge (5000 r / min, 10 min), take the supernatant, and add absolute ethanol to make the final concentration of 60% (v / v ), overnight; centrifuge (3000 r / min, 5 min), take the precipitate, and dry it in vacuum to obtain dry fucoidan powder.

[0046] Hydrolysis: mix fucoidan dry powder with pectinase (enzyme activity: 500,000 U / g) (Huzhou Lilly Biotechnology C...

Embodiment 2

[0057] Prepare according to the proportioning in Table 1.

[0058] The preparation method is the same as that of Example 1.

Embodiment 3

[0060] Prepare according to the proportioning in Table 1.

[0061] The preparation method is the same as that of Example 1.

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Abstract

The invention provides a polysaccharide compound for preventing and treating porcine diarrhea and application thereof. The polysaccharide compound is composed of 50-90 wt% of oligomer fucosan and 10-50 wt% of PZ-1 bacterial extracellular polysaccharide, wherein the PZ-1 bacterial extracellular polysaccharide is prepared by fermenting Proteus penneri PZ-1 and performing extraction and purification; and the oligomer fucosan is prepared by the following steps: extracting from Laminaria digitata powder, hydrolyzing and separating with a hyperfiltration membrane. The oligomer fucosan and the PZ-1 bacterial extracellular polysaccharide are crudely mixed proportionally by a progressive mixing method, and finally mixed uniformly to obtain the polysaccharide compound. The polysaccharide compound provided by the invention can reduce the consumption of antibiotic medicines in the pig breeding process, provides safe and green pork products for consumers, and effectively prevents and treats porcine diarrhoea. The polysaccharide compound can be used as a substitute of an antibiotic medicine for treating porcine diarrhea. The polysaccharide compound has better effect than the single oligomer fucosan or PZ-1 bacterial extracellular polysaccharide, and much better than the simple addition of the oligomer fucosan and PZ-1 bacterial extracellular polysaccharide.

Description

technical field [0001] The invention relates to the field of biological preparations, and relates to the application of oligomeric fucoidan and PZ-1 bacterial exopolysaccharide to prepare drugs for preventing and treating swine diarrhea. Background technique [0002] Diarrhea is a common and frequently-occurring disease in pigs. In recent years, the incidence of porcine diarrhea has been increasing, especially in piglets due to their poor resistance. According to reports, porcine diarrhea disease broke out in a large area in early 2012, and the incidence rate of small and medium-sized pig farms with less than 200 basic sows reached 20%-40%; diarrhea was particularly serious in sows and piglets one week after delivery, and piglet mortality in some pig farms Up to 100%, causing immeasurable losses to the pig industry. [0003] The main cause of swine diarrhea is pathogenic bacteria and virus infection. For example, pathogenic Escherichia coli is a major cause of yellow and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61P1/12A61P37/02A61P31/12C12P19/14C12P19/04A61K31/715C12R1/01
Inventor 刘翼翔吴永沛谢荔朋
Owner 福建九为生物技术有限公司
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