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Preparation method of traditional Chinese medicine ointment

A technology for ointment and ointment clearing, which is applied in the direction of ointment delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as lack of gloss, poor adhesion, and failure to achieve therapeutic effects

Active Publication Date: 2014-11-19
BEIJING SHOUER PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 1. The ointment is thin, and the adhesion on the skin is not good during use, so the desired therapeutic effect cannot be achieved;
[0008] 2. The ointment is not delicate enough, lacks gloss, and the color is darker (tan), and the overall appearance of the product is not good

Method used

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  • Preparation method of traditional Chinese medicine ointment
  • Preparation method of traditional Chinese medicine ointment
  • Preparation method of traditional Chinese medicine ointment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Weigh 15g Nepeta panicle, 12g Forsythia, 15g Angelica dahurica, 9g Atractylodes atractylodes, 12g Clematis clematis, 9g rhubarb, 30g Dafengzi, 3g white fresh skin, add 70% ethanol (using Alcohol density meter for measurement) reflux extraction twice, the amount of 70% ethanol added for the first time is 10 times the volume of the decoction pieces, then heated and boiled and then counted for 2 hours; the amount of 70% ethanol added for the second time is 8 times the volume of the dregs , and then heated and boiled and counted for 1 hour, the two reflux liquids were respectively passed through 80-mesh sieves, and then combined in a stainless steel bucket, covered and stored for later use.

[0035] (2) Transfer the reflux alcohol extraction solution to a reflux concentration tank and concentrate under reduced pressure until there is no alcohol smell, and then continue to concentrate until the relative density of the resulting clear paste at 50°C is 1.00-1.02.

[0036] ...

Embodiment 2

[0044] (1) Weigh 15g Nepeta panicle, 12g Forsythia, 15g Angelica dahurica, 9g Atractylodes atractylodes, 12g Clematis clematis, 9g rhubarb, 30g Dafengzi, 3g white fresh skin, add 70% ethanol (using Alcohol density meter for measurement) reflux extraction twice, the amount of 70% ethanol added for the first time is 10 times the volume of the decoction pieces, then heated and boiled and then counted for 2 hours; the amount of 70% ethanol added for the second time is 8 times the volume of the dregs , and then heated and boiled and counted for 1 hour, the two reflux liquids were respectively passed through 80-mesh sieves, and then combined in a stainless steel bucket, covered and stored for later use.

[0045] (2) Transfer the reflux alcohol extraction solution to a reflux concentration tank and concentrate under reduced pressure until there is no alcohol smell, and then continue to concentrate until the relative density of the resulting clear paste at 50°C is 1.00-1.02.

[0046] ...

Embodiment 3

[0054] (1) Weigh 15g Nepeta panicle, 12g Forsythia, 15g Angelica dahurica, 9g Atractylodes atractylodes, 12g Clematis clematis, 9g rhubarb, 30g Dafengzi, 3g white fresh skin, add 70% ethanol (using Alcohol density meter for measurement) reflux extraction twice, the amount of 70% ethanol added for the first time is 10 times the volume of the decoction pieces, then heated and boiled and then counted for 2 hours; the amount of 70% ethanol added for the second time is 8 times the volume of the dregs , and then heated and boiled and counted for 1 hour, the two reflux liquids were respectively passed through 80-mesh sieves, and then combined in a stainless steel bucket, covered and stored for later use.

[0055] (2) Transfer the reflux alcohol extraction solution to a reflux concentration tank and concentrate under reduced pressure until there is no alcohol smell, and then continue to concentrate until the relative density of the resulting clear paste at 50°C is 1.00-1.02.

[0056] ...

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Abstract

The invention discloses a preparation method of a traditional Chinese medicine ointment. The preparation method is characterized by comprising the following steps: carrying out ethanol reflux extraction on eight herbal pieces, concentrating into clear cream of which the relative density is 1.00-1.05; separately heating and melting on an oil phase; firstly, dissolving glycerol into water; mixing the clear cream with a water phase and then mixing with the glycerol; adding triethanolamine to a water-phase pot; and controlling the emulsification temperature at 68-72 DEG C. The preparation method has the beneficial effects that the glycerol is in a liquid state, so that the condition that the water phase is evenly mixed with water can be ensured by mixing with water in advance; the clear cream and other water-phase materials in a solid state or semi-solid state are heated to boil; the clear cream and other water-phase materials can be completely melted and fully mixed, so that the emulsification effect of the next step is ensured. The triethanolamine is independently watered and mixed; the reaction of the triethanolamine and parietic acid in the clear cream is avoided; the mixture can be rapidly emulsified after the triethanolamine is added, so that the ointment prepared by the method is not only light in color (faint yellow to yellowish-brown), but also exquisite, and has glossiness, proper thin consistency and better skin adhesion.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine ointment, belonging to the field of pharmaceutical preparations. Background technique [0002] In the official reply (99) Jingwei Yaozhi Shenzi No. 326, the prescription and preparation method of the traditional Chinese medicine ointment Fule cream are given: [0003] [0004] Preparation method: the above ten flavors, except vitamin E and dexamethasone acetate, the remaining eight flavors are extracted twice with 70% ethanol under reflux, the first time is 2 hours, the second time is 1 hour, the alcohol liquid is combined, filtered, and the filtrate is recovered Ethanol until alcohol-free, add vitamin E, dexamethasone acetate, mix well, cool to 75°C, set aside; take another 80g of glycerin, 16g of polyethylene glycol-2000, 56g of cetyl alcohol, 80g of stearic acid, and 80g of silicone oil , Azone 30g, Triethanolamine 30g, Ethyl p-Hydroxybenzoate 1g, Disodium EDTA 1g, m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/75A61K9/06A61P17/00A61K31/355A61K31/573
Inventor 凌科
Owner BEIJING SHOUER PHARMA FACTORY
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