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Ming human infiltrating type gastric cancer cell line and application thereof

A gastric cancer cell line and gastric cancer cell technology, applied to Ming's human infiltrating gastric cancer cell line and its application field, can solve the problems such as few, Ming's gastric cancer cell line has not been reported, and achieve the effect of strong clone formation ability

Active Publication Date: 2013-11-20
ZHONGSHAN HOSPITAL XIAMEN UNIV
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AI Technical Summary

Problems solved by technology

[0006] So far, there have been many reports on the clinical and basic research of gastric cancer in the world, but there are not many reports on the mechanism of gastric cancer from the perspective of Ming's classification, and there are no reports on Ming's gastric cancer cell lines.

Method used

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  • Ming human infiltrating type gastric cancer cell line and application thereof
  • Ming human infiltrating type gastric cancer cell line and application thereof
  • Ming human infiltrating type gastric cancer cell line and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] The experimental methods described in the following examples are conventional methods unless otherwise specified.

[0028] Establishment and identification of Ming's infiltrating gastric cancer cell line XGC-1.

[0029] 1. Establishment of Ming's infiltrating gastric cancer cell line XGC-1

[0030] The cell tumor specimen of this strain was taken from a male patient with gastric antrum cancer. After conventional pathological examination, HE staining identified it as Ming's infiltrating gastric cancer, and the cancer tissue showed diffuse infiltrating growth ( figure 1 ). The primary culture of gastric cancer cells was repeatedly purified, and after stable passage, the Ming's infiltrating gastric cancer cell line was established.

[0031] 2. Detection of biological characteristics of Ming's infiltrating gastric cancer cell line XGC-1

[0032] 1. Cell morphology: After the cells were passaged, purified and grown stably, the cultured cells were observed as live cells; t...

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Abstract

The invention provides a Ming human infiltrating type gastric cancer cell line and an application thereof and relates to a microorganism animal cell line. The gastric cancer cell line is a Ming human infiltrating type gastric cancer cell line XGC-1 with the preservation number of CCTCC NO:C201385. The invention also provides an application of the Ming human infiltrating type gastric cancer cell line XGC-1 in establishment of a cell model showing occurrence, development or transfer of a Ming infiltrating type gastric cancer, an application of the Ming human infiltrating type gastric cancer cell line XGC-1 in establishment of a Ming infiltrating type gastric cancer animal model, an application of the Ming human infiltrating type gastric cancer cell line XGC-1 in establishment of a cell model for studying a differentiation mechanism, cellular morphology, dysfunction and a tumor infiltration transferring mechanism of gastric cancer and guiding clinical comprehensive diagnosis and treatment in a Ming parting aspect and an application of the Ming human infiltrating type gastric cancer cell line XGC-1 in study of a gastric cancer occurrence mechanism and screening of medicines used for preventing and treating gastric cancer.

Description

technical field [0001] The invention relates to microbial animal cell lines, in particular to a Ming's infiltrating gastric cancer cell line and its application. Background technique [0002] Gastric cancer is one of the most common malignant tumors. In the world, the incidence of gastric cancer ranks fourth among all malignant tumors, and the mortality rate ranks second. In China, gastric cancer is the most common digestive tract tumor, accounting for the first place in the mortality rate of malignant tumors. The national average annual mortality rate is 16 / 100,000 population, and the high-incidence area reaches 60 / 100,000 population. Although great progress has been made in the diagnosis and treatment of gastric cancer, its 5-year survival rate has not improved significantly in the past 10 years. Postoperative recurrence and metastasis are the important causes of its death. The research and treatment of gastric cancer has become a major issue to be solved urgently. Curre...

Claims

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Application Information

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IPC IPC(8): C12N5/09C12Q1/02A01K67/027
Inventor 蔡建春彭积贵徐浩骆启聪
Owner ZHONGSHAN HOSPITAL XIAMEN UNIV
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