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Chinese medicine composition and preparation method and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and its preparation, can solve the problems of inconvenience for patients, not being widely used, poor taste, etc., and achieve the effect of reasonable proportion

Active Publication Date: 2013-11-20
史志辉 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, although Fuzheng Sanjie Decoction has shown a good therapeutic effect on advanced liver cancer in clinical application, it has not been widely used.
The reason is that the way of taking it has become the biggest obstacle that the decoction cannot be widely used
Traditional Chinese medicine decoction needs to be taken three times a day, and it needs to go through a long decoction process before taking it, and the decoction time, the amount of water added, and the firepower need to be strictly controlled, but this is not enough for ordinary patients. easy to do
Therefore, the decoction process of traditional Chinese medicine has brought great inconvenience to the patient
On the other hand, the taste of traditional Chinese medicine decoction is not good, but the dosage is not large, which also brings unnecessary pain to patients

Method used

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  • Chinese medicine composition and preparation method and application thereof
  • Chinese medicine composition and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Active ingredient content determination in crude drug of embodiment 1

[0054] 1) Astragalus polysaccharide content determination

[0055] The experimental method is as follows: Draw a standard curve: Accurately weigh 250 mg of reference substance glucose (batch number: 110928-200915, for content determination) dried at 105 °C to constant weight, put it in a 50 mL volumetric flask, add water to the mark and shake well to prepare the A solution containing 5 mg of anhydrous glucose per 1 mL. Accurately draw 1.0, 2.0, 3.0, 4.0, 5.0, 6.0, 7.0mL, put them into iodine measuring bottles respectively, add 20mL of Fehling's test solution to each precision, boil for 3 minutes, let cool, add hydrochloric acid (6mol / L) 10mL Immediately titrate with sodium thiosulfate solution (0.1mol / L) to pale yellow, add 2mL of starch indicator solution, and continue titrating until the blue color disappears. In addition, 5 mL of water was used as the blank control in the same way, and the diff...

Embodiment 2

[0112] Embodiment 2 Medicinal material infiltration time investigation

[0113] Dried Chinese medicinal materials shrink due to dehydration, and the ingredients are consolidated in the cells. The semipermeability of the cells is destroyed after drying, and the active ingredients in the medicinal materials can be dissolved and leached by the leaching solvent. In the decoction method and ethanol reflux extraction method, the protein on the surface of the medicinal material is heated and solidified, and the starch is gelatinized, which prevents water and ethanol from penetrating into the medicinal material and affects the extraction of active ingredients. favorable. Therefore, the investigation of infiltration time must be carried out. Since the particle size of medicinal materials is an important condition affecting the extraction rate of Chinese medicinal materials, the finer the crushing, the larger the surface area of ​​the powder particles, which is more conducive to leachi...

Embodiment 3

[0119] The preparation condition screening of the first intermediate product of embodiment 3

[0120] Take Poria cocos to remove impurities, wash, dry, accurately weigh three parts, crush each part of 25g, pass through a 100-mesh sieve to obtain Poria cocos powder, and then accurately weigh the weight of the three parts of fine powder, the powder collection rate is 98.8% respectively , 99.1%, 99.4%, with an average of 99.1%;

[0121] Take 1g toad venom, mash it, add 2 times the volume fraction of 60% ethanol aqueous solution to impregnate, stir frequently until it becomes a thick paste, dry, accurately weigh three parts, crush, pass through a 100-mesh sieve to obtain toad venom powder, and weigh them separately Get the weight of these three parts of fine powder, the powder collection rate is respectively 99.3%, 99.5%, 99.4%, is 99.4% on average.

[0122] Since some active ingredients in Poria cocos and toad venom are unstable to heat, their activity will be rapidly lost by he...

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Abstract

The invention relates to the field of traditional Chinese medicines, and in particular relates to a Chinese medicine composition and a preparation method and an application thereof. The Chinese medicine composition is prepared from the following raw materials in parts by weight: 750 parts of Astragalus membranaceus, 500 parts of curcuma zedoary, 250 parts of Peganum harmala, 62.5 parts of Poria cocos, 2.5 parts of venenum bufonis, 125 parts of Rabdosia rubescens and 250 parts of radix bupleurim. According to the composition, a prescription of traditional body-strengthening and stasis-removing decoction is adjusted, and the use level of medicinal materials is reduced. The novel preparation method is adopted to respectively extract different medicines by different manners in allusion to effective components in the medicine, so that the transfer rate of effective substances is ensured. The Chinese medicine composition can be used for preparing medicines for treating advanced liver cancer, and the dosage form is free from a long time decocting process before administration as the traditional body-strengthening and stasis-removing decoction is to be decocted. The composition is accurate in dosage, convenient to store and stable in property, the patient is convenient to take the composition, and unnecessary pain caused by bad taste of the traditional decoction to the patient is further avoided.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition and its preparation method and application. Background technique [0002] Although Chinese medicine does not have a disease name for liver cancer, its symptoms and etiology have long been recorded. According to the symptom of liver cancer with a right upper quadrant mass, some doctors believe that "covering under the right flank as big as a cup" recorded in "Nei Jing"; The disease may be included in the "hepatic accumulation" and other diseases mentioned in ". Traditional Chinese medicine believes that liver cancer is the same as other cancers. The etiology is divided into external and internal causes. Exogenous pathogenic factors and internal injuries are related to eating disorders. It is more common in the elderly and people with spleen and kidney failure. Its pathogenesis is due to the imbalance of yin and yang, qi and bl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/20A61K9/48A61P35/00A61K35/56A61K35/65
Inventor 史志辉
Owner 史志辉
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