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Rhodiola rosea micro powder tablet and preparation method thereof

The technology of Rhodiola rosea and micropowder tablets is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and devices for making medicines into special physical or taking forms, so as to achieve low preparation cost, improve curative effect, and prevent extrusion. heat effect

Inactive Publication Date: 2013-11-06
曹静
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In a word, there is no report that only rhodiola micropowder is compressed into tablets without adding any auxiliary materials.

Method used

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  • Rhodiola rosea micro powder tablet and preparation method thereof
  • Rhodiola rosea micro powder tablet and preparation method thereof
  • Rhodiola rosea micro powder tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1 micropowder direct compression tablet process

[0073] 1. Raw materials: Rhodiola micropowder, particle size D90=25-45μm, moisture content about 8%.

[0074] 2. The rotation speed of the tablet press is 15 / h, the pre-compression pressure is 8kN, and the main pressure is 8kN.

[0075] 3. The tableting temperature is set to 5°C.

[0076] 4. The ambient temperature is 22°C and the ambient humidity is 48%.

[0077] Compress tablet according to above-mentioned process, tablet specification 0.25g / tablet, 100 tablets.

Embodiment 2

[0078] Embodiment 2 cycle tabletting process

[0079] 1. Raw material: Rhodiola micropowder, particle size D90=25-45μm, moisture content more than 8%.

[0080] 2. The rotation speed of the tablet press is 15 / h, the pre-compression pressure is 8kN, and the main pressure is 8kN.

[0081] 3. The tableting temperature is set to 5°C.

[0082] 4. The ambient temperature is 22°C and the ambient humidity is 48%.

[0083] When compressing tablets according to the above process, the powder is first pressed into tablets, then crushed through a 60-80 mesh sieve, and then compressed into tablets again. If the requirements are not met, repeat the steps of tablet compression until the quality of the tablet is qualified, and the tablet specification is 0.25g / piece, 100 pieces.

Embodiment 3

[0084] Embodiment 3 cycle tabletting process

[0085] 1. Raw material: Rhodiola micropowder, particle size D90=25-45μm, moisture content more than 8%.

[0086] 2. The rotation speed of the tablet press is 15 / h, the pre-compression pressure is 8kN, and the main pressure is 8kN.

[0087] 3. The tableting temperature is set to 5°C.

[0088] 4. The ambient temperature is 22°C and the ambient humidity is 48%.

[0089] Press the tablet according to the above process, first press the powder into a large plate, then crush it through a 60-80 mesh sieve, and then press it again. The tablet specification is 0.25g / tablet, 100 tablets.

[0090]Rhodiola rosea was pressed into tablets through three kinds of process compression, and the obtained tablets were compared in quality, see Table 6.

[0091] Table 6 Comparison table of three kinds of process results (based on 100 micropowder tablets)

[0092]

[0093] Through the comparison in the above table 6, the above three processes can b...

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Abstract

The invention discloses a rhodiola rosea micro powder tablet and a preparation method thereof and aims at solving the problem that existing tabletting processes need additional auxiliary materials and the content of effective constituents of prepared tablets is low. The rhodiola rosea micro powder tablet has water content 3-15%, the partical size of the tablet is 1-150mum, the rhodiola rosea micro powder tablet is prepared at the tabletting temperature of subzero 10-10 DEG C, any auxiliary material is not added in the preparation process, and rhodiola rosea micro powder is an unique constituent of the tablet. The purpose of direct tabletting and forming can be achieved by controlling moisture and the temperature or by adopting a circular tabletting process or a dry granulating and tabletting process. The process enables the tablet to be good in appearance and enables the pitted surface rate and the breakage rate to be low, the hardness, the disintegration degree and the breakage degree of the tablet meet the requirement for tablet quality, and the hardness can further ensure the tablet not to fragment in the coating and film covering treatment process of the tablet.

Description

technical field [0001] The invention belongs to the field of medicine and health food, and in particular relates to a rhodiola micropowder tablet and a preparation method thereof. Background technique [0002] Usually, when preparing tablets, those skilled in the art must first select appropriate excipients according to the properties of the drug and the requirements of clinical medication, and then mix and process them to make them have good fluidity and compressibility. (Chinese Medicine Pharmaceutics, China Press of Traditional Chinese Medicine, first edition in January 2003, p411, penultimate paragraph 2), the choice of excipients is extremely important during direct compression, the most important of which are fillers and binders, They are the key to tableting. The excipients in the direct compression tablet prescription, especially the role of fillers and binders, are more important in the wet granulation method (Chinese Medicine Pharmaceutics, China Traditional Chine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A61K9/20A61J3/10
Inventor 曹静
Owner 曹静
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