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Porous hemostatic powder and its preparation method

A technology of hemostatic powder and porous microspheres, which is applied in the field of medical materials, can solve the problems of poor adsorption function of hemostatic materials, inconvenient clinical use, and poor safety, and achieve the effects of easy operation, low production cost, and wide range of raw materials

Inactive Publication Date: 2013-11-06
QINGDAO ZHONGTENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] One purpose of the present invention is to solve the problem of poor adsorption function, insufficient viscosity and inconvenient clinical use of the hemostatic material in the prior art
In addition, the existing products cannot solve the problem of postoperative adhesion, and the safety of in vivo use is poor. Therefore, a soluble hemostatic powder that can stop bleeding and prevent postoperative adhesion and can be safely used in the body is provided.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Weigh 50g of soluble starch, molecular weight specification: 20000-40000 Daltons, and place it on the ultrasonic vibration bed device (Model DL-120E of Shanghai Wuxiang Instrument Co., Ltd.), open the device, the vibration frequency is 40KHz, and use 120 laser beams at the same time. 30 minutes.

[0016] Microscopic observation of the number of microparticle holes

[0017] Name of particles after perforation Particle diameter (micron) Number of holes 1 Φ2156 2 Φ2378 3 Φ2887 4 Φ2662 5 Φ19 51

[0018] Conclusion: The laser drilling is evenly distributed, and the number of holes per particle can exceed 32.

Embodiment 2

[0020] Weigh 30g sodium carboxymethyl cellulose, molecular weight specification: 20000-40000 Daltons, and place it on the ultrasonic vibration bed device (Model DL-120E of Shanghai Wuxiang Instrument Co., Ltd.), turn on the device, and use the vibration frequency at 40KHz. 120 laser beams are irradiated for 30 minutes.

Embodiment 3

[0022] The effectiveness of this experimental product is judged by the observation and comparison of hemostasis time in the mouse bleeding model and the absorbable subcutaneous implantation experiment.

[0023] 1. Hemostatic test

[0024] Twenty-four healthy adult ICR mice, weighing 20±2g, half male and half male, were randomly divided into 2 groups: (1) test group; (2) control group. After intraperitoneal injection of 10% urethane with 1g / kg anesthetized, minus 1cm of the tail of the mouse, cover with hemostatic powder or a small piece of control sterile gauze when bleeding, and reduce pressure. At the same time, start timing, suck blood from the wound with filter paper every 10 seconds until bleeding stops, record the bleeding time, statistically process the data, and conduct a significant t test between groups. Results The bleeding time of the experimental group was 0.9±1.12 (min), and that of the sterile gauze group was 4.98±1.45. There was a significant difference between the...

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Abstract

The invention provides a porous hemostatic powder which is prepared by carrying out physical drilling on a soluble material to form porous microspheres. A preparation method of the porous styptic powder comprises the following steps: putting the soluble material on a supersonic vibration bed device, starting the device, vibrating, and simultaneously carrying out laser radiation for 10-60 min. The soluble material undergoes laser drilling. The preparation method has advantages of simple technology, easy operation, low production cost and wide raw material sources. Soluble starch, carboxy methyl starch, hydroxyethyl starch, carboxymethylcellulose sodium, ethyl cellulose or sodium alginate and their derivatives are medically proved to be safe medical materials, are generally used as pharmaceutic adjuvants and sustained release agents of medicines, and are also used to prepare absorbable hemostatic gauze such as Tailing absorbable hemostatic gauze. These materials are all dissoluble; the size of molecular weight is controllable; preferably, the molecular weight is 500-12000Dalton; more preferably, the molecular weight is 1000-40000 Dalton; and the materials all can be absorbed by body.

Description

Technical field [0001] The invention relates to a medical material, in particular to a porous hemostatic powder and a preparation method thereof. Background technique [0002] Bleeding is one of the main causes of death in trauma and war wounded patients. Fast and effective control of bleeding can significantly reduce deaths caused by bleeding. Powdered hemostatic products are not affected by the size and location of the wound and have unique advantages. At present, foreign hemostatic powders are made of soluble starch through cross-linking reaction to construct three-dimensional porous particles, which are prone to residues of chemical reagents or cleaning agents. And it is expensive. Summary of the invention [0003] An object of the present invention is to solve the problems of poor absorption function of hemostatic materials in the prior art, insufficient viscosity, and inconvenience for clinical use. In addition, the existing products cannot solve the problem of postoperat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/718A61K31/717A61K31/734A61K9/14A61L15/28A61L15/44B23K26/38A61P7/04A61P41/00
Inventor 李洪波
Owner QINGDAO ZHONGTENG BIOTECH
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