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Sulfamonomethoxine-ciprofloxacin-fosfomycin combined injection for veterinary use and preparation method thereof

A technology of sulfamethoxine and ciprofloxacin, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, drug delivery, etc., can solve the problems of mixed infection and secondary infection without obvious effect, and achieve the goal of preventing bacteria Effects of drug resistance, ensuring quality and safety, and enhancing drug efficacy

Inactive Publication Date: 2013-10-23
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN1843328A discloses compound enrofloxacin-sulfamethoxine injection and preparation method thereof, and its therapeutic effect has greater improvement than using enrofloxacin injection or sulfamethoxine injection alone, but its effect on The effect of mixed infection and secondary infection caused by Escherichia coli, Salmonella, Staphylococcus, Streptococcus, Proteus, Shigella, Klebsiella pneumoniae and other bacteria is still not obvious

Method used

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  • Sulfamonomethoxine-ciprofloxacin-fosfomycin combined injection for veterinary use and preparation method thereof
  • Sulfamonomethoxine-ciprofloxacin-fosfomycin combined injection for veterinary use and preparation method thereof
  • Sulfamonomethoxine-ciprofloxacin-fosfomycin combined injection for veterinary use and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Sulfamethoxine-ciprofloxacin-fosfomycin combined injection for veterinary use, each 100mL of the injection includes the following components:

[0031]

[0032] Wherein, the adjusted pH value is 9.7.

[0033] The veterinary sulfamethoxine-ciprofloxacin-fosfomycin combined injection is prepared by the following steps:

[0034] (1) Dissolve 10 g of sulfamethoxine sodium and 0.2 g of fosfomycin sodium in sequence with 20 mL of water for injection to prepare liquid A;

[0035](2) After stirring and dissolving 10 g of polyethylene glycol 400 with 20 mL of water for injection, add 2 g of ciprofloxacin, stir well, then add an appropriate amount of ethanolamine, and after fully dissolving, liquid B is prepared;

[0036] (3) Add liquid A into liquid B, stir well until it is clear and transparent, and obtain liquid C;

[0037] (4) Add 1 g of benzyl alcohol, 0.1 g of sodium thiosulfate, and 0.01 g of disodium ethylenediamine tetraacetate into liquid C, and stir until dissolved...

Embodiment 2

[0041] Sulfamethoxine-ciprofloxacin-fosfomycin combined injection for veterinary use, each 100mL of the injection includes the following components:

[0042]

[0043]

[0044] Wherein, the adjusted pH value is 9.8.

[0045] The steps of the preparation method are the same as in Example 1.

Embodiment 3

[0047] Sulfamethoxine-ciprofloxacin-fosfomycin combined injection for veterinary use, each 100mL of the injection includes the following components:

[0048]

[0049] Wherein, the adjusted pH value is 10.2.

[0050] The steps of the preparation method are the same as in Example 1.

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Abstract

The invention discloses a sulfamonomethoxine-ciprofloxacin-fosfomycin combined injection for veterinary use and a preparation method thereof. Every 100mL of the sulfamonomethoxine-ciprofloxacin-fosfomycin combined injection for veterinary use comprises the following components by weight: 5-15g of sulfamonomethoxine sodium, 1-5g of ciprofloxacin, 0.1-0.5g of fosfomycin sodium, 0.5-1.5g of an analgesic, 0.1-0.2g of an antioxidant, 5-20g of a cosolvent, 0.01-0.05g of ethylenediamine tetraacetic acid disodium salt, an appropriate amount of a pH regulator, and the balance of water for injection. The preparation method of the sulfamonomethoxine-ciprofloxacin-fosfomycin combined injection mainly comprises the steps of liquid preparation, filtration, packaging and sterilization. According to the injection, three types of drugs are in reasonable compatibility, and different antibacterial mechanisms of the three drugs are used for inhibiting and killing pathogenic bacteria in various ways, so that the injection has broad-spectrum antibacterial activity and can not generate drug tolerance easily, the dosage is reduced, harms caused by residual antibiotics are lowered, and the safety of livestock and poultry products is ensured favorably.

Description

technical field [0001] The invention relates to the field of veterinary drug injections, in particular to veterinary sulfamethoxine-ciprofloxacin-fosfomycin combined injection and a preparation method thereof. Background technique [0002] Sulfamethoxine has the strongest antibacterial activity and the least side effects among sulfa drugs, and is cost-effective and widely used. Its injection is usually in the form of sodium salt, which has a strong antibacterial effect on most Gram-positive bacteria and some Gram-negative bacteria. In veterinary medicine, it is mainly used to treat piglet edema caused by sensitive bacteria, pig atrophic rhinitis, actinobacillus pleuropneumonia, piglet yellow scour, pullorum, swine toxoplasmosis, swine colibacillosis, pullorum, fowl typhoid, Avian colibacillosis, chicken infectious rhinitis, etc. Sulfamethoxine competes with p-aminobenzoic acid for dihydrofolate synthase, reduces the amount of folic acid synthesis, reduces the amount of met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/665A61K9/08A61P31/04A61K31/635A61K31/496
Inventor 张巧艳钱鸣蓉吴俐勤周育李锐汪建妹吉小凤
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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