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Strontium magnesium-doped nano-hydroxyapatite and preparation method thereof

A nano-hydroxyapatite, strontium-magnesium nanotechnology is applied in the field of strontium-magnesium-containing nano-hydroxyapatite and its preparation, which can solve the problems of slow reaction speed, large product particle size, low product purity, etc. Repair cycle, improve solubility

Inactive Publication Date: 2013-10-09
MICRO STRUCTURE ANALYTICAL LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods have their own advantages and disadvantages, such as: the acid-base reaction method has simple equipment, but the crystallinity of the product is poor; the precipitation reaction method is simple and convenient, but the product purity is low; Slow speed, large product particle size

Method used

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  • Strontium magnesium-doped nano-hydroxyapatite and preparation method thereof
  • Strontium magnesium-doped nano-hydroxyapatite and preparation method thereof
  • Strontium magnesium-doped nano-hydroxyapatite and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0019] Add 23.6g of calcium nitrate into deionized water to prepare liquid A; dissolve 9.12g of ammonium hydrogen phosphate in deionized water to prepare liquid B; slowly add liquid B to liquid A at 90°C, and use ammonia water under continuous stirring Adjust the pH value to 7-8, react for 2 hours, let it stand for 24 hours, filter and wash the precipitate, put it in a reaction kettle at 80°C for 4 hours, wash the obtained slurry with deionized water, and dry at room temperature to obtain nano-hydroxyapatite .

Embodiment 2

[0021] Add 23.6g of calcium nitrate into deionized water to prepare liquid A; dissolve 0.53g of strontium nitrate in deionized water to prepare liquid B; dissolve 5.12g of magnesium nitrate in deionized water to prepare liquid C; dissolve 11.10g of hydrogen phosphate Dissolve ammonium in deionized water to prepare liquid D; slowly add liquid B, liquid C, and liquid D to liquid A at 90°C at the same time, adjust the pH value to 7-8 with ammonia water under continuous stirring, react for 2 hours, and statically After 24 hours, the precipitate was filtered and washed, and placed in a reaction kettle at 80°C for 4 hours. The obtained slurry was washed with deionized water and dried at room temperature to obtain nano-hydroxyapatite containing 2.5% strontium and 20% magnesium.

Embodiment 3

[0023] Add 23.6g of calcium nitrate into deionized water to make liquid A; dissolve 1.06g of strontium nitrate in deionized water to make liquid B; dissolve 2.56g of magnesium nitrate in deionized water to make liquid C; dissolve 10.49g of hydrogen phosphate Dissolve ammonium in deionized water to prepare liquid D; slowly add liquid B, liquid C, and liquid D to liquid A at 90°C at the same time, adjust the pH value to 7-8 with ammonia water under continuous stirring, react for 2 hours, and statically After standing for 24 hours, the precipitate was filtered and washed, and placed in a reaction kettle at 80°C for 4 hours. The resulting slurry was washed with deionized water and dried at room temperature to obtain nano-hydroxyapatite containing 5% strontium and 10% magnesium.

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Abstract

The invention discloses strontium magnesium-doped nano-hydroxyapatite and a preparation method thereof. The method comprises the following steps of: simultaneously and slowly adding a strontium nitrate liquor, a magnesium nitrate liquor and an ammonium hydrogen phosphate liquor by a predetermined molar ratio to a nitric acid liquor at 80-90 DEG C; adjusting pH value to 7-8 by ammonia water under continuous stirring; reacting for 2-3 hours, and standing for 24-48 hours; filtering and washing the precipitate; placing the precipitate in a reaction kettle for reaction for 4-6 hours at 80-90 DEG C; and cleaning and drying the slurry obtained to obtain the rod-like strontium magnesium-doped nano-hydroxyapatite free from solvent residue with small particle diameter. The strontium magnesium-doped nano-hydroxyapatite can be used as a novel biological material for repairing hard tissues, better simulates natural bone, and has the capacity of shortening the bone repairing period.

Description

technical field [0001] The invention relates to nano-hydroxyapatite, in particular to nano-hydroxyapatite containing strontium and magnesium produced by reacting phosphate and nitrate and a preparation method thereof. Background technique [0002] In the 20th century, the field of biomaterials has achieved rapid development, and the research and application of inorganic biomedical materials are very active. Among them, the research and clinical application of hydroxyapatite (HA or HAP) active ceramic materials have attracted much attention. . Synthetic hydroxyapatite has similar chemical composition and structure to biological hard tissues, is non-toxic, safe, has good biocompatibility and biological activity, has no stimulation and repulsion to tissues after implantation in the human body, and can Actively combined with the surrounding bone tissue, and can conduct bone growth, it is an ideal hard tissue replacement material. Hydroxyapatite has been widely used clinically ...

Claims

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Application Information

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IPC IPC(8): C04B35/447C04B35/626B82Y40/00
Inventor 刘晓晨倪寿亮
Owner MICRO STRUCTURE ANALYTICAL LAB
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