Regeneration bone scaffold forming system and method based on comprehensive 3D printing formation

Abstract

The invention relates to a regeneration bone scaffold forming system and method based on comprehensive 3D printing formation. A comprehensive 3D printing formation technology method of a regeneration bone scaffold can be built by combining an electrospinning technology and a freeze drying technology, a digital system integration method which can realize the 3D printing formation processes of the electrospinning formation and a modeling structure can be given on the basis, and finally the specific system realization method and operation steps can be given. The data processing method of the built comprehensive 3D printing formation system comprises the steps of: completing filling and lapping on each layer of the scaffold by adopting a parallel and repeated path scanning method, judging adjacent fibers through adopting a transition line method and conducting curve fitting to realize the formation of complicated contour boundaries and realize the automatic integration management of the 3D printing formation processes of the electrospinning formation and the modeling structure through specific post-processing. The regeneration bone scaffold forming system and method based on the comprehensive 3D printing formation are key technologies for realizing the multiscale formation of the regeneration bone scaffold, and have obvious characteristics.

Description

technical field [0001] The invention relates to a regenerative bone scaffold forming method and system based on 3D printing comprehensive forming, which belongs to the field of biomanufacturing and is an intersecting field of mechanical engineering, information, tissue engineering and life sciences. Background technique [0002] Bone defects can be caused by trauma, tumors, congenital deformities, bone infections, etc. Bone defect repair (Bone Defect Repair) is the most common tissue transplantation operation except for blood transplantation (blood transfusion). In European and American countries, the amount of bone graft materials is second only to blood, and it has become the second most used transplant tissue. In addition, according to relevant data, about 3.5 million people in my country suffer from different degrees of bone defects due to traffic accidents every year, and a large number of patients have to undergo repair of large bone defects. It can be seen that bone...

AI Technical Summary

Problems solved by technology

[0004] However, the current traditional bone scaffold preparation process has the following problems: (1) The controllability of materials is poor, and it is difficult to manufacture bone scaffolds with complex heterogeneous porous structures; (2) The pore structure, the positional relationship and the connectivity relationship between pores cannot Accurate realization; (3) Using manual manufacturing methods, the precise shape and structure of the bracket cannot be guaranteed

However, the scaffold made of fibers ejected by electrospinning technology is similar to the disordered non-woven fabric, so it is difficult to precisely control the shape of the scaffold.

It is not difficult to see that the current single process method cannot achieve multi-scale forming, so it cannot meet the macroscopic contour forming requirements and microscopic pore forming requirements of bone scaffolds at the same time.

Images