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Virus inactivator

A virus inactivation and photocatalyst technology, applied in the directions of disinfectants, biocides, animal repellents, etc., can solve the problems of undisclosed antiviral effects and inability to know the inactivation effects of monovalent copper compounds on viruses.

Active Publication Date: 2013-10-02
THE UNIV OF TOKYO +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Cu 2 The antiviral effect of O itself, those skilled in the art based on the disclosure of the above-mentioned publications cannot know whether the monovalent copper compound has an inactivation effect on the virus

Method used

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Examples

Experimental program
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Effect test

example 1

[0087] Although the virus inactivation ability was also evaluated for influenza virus, it was mainly confirmed by the following method by a model experiment using phage. A method using the inactivation ability of phage as a model of virus inactivation ability is described in, for example, Appl. Microbiol. Biotechnol., 79, pp. 127-133, 2008, and it is known that reliable results can be obtained.

[0088] Cover a deep Petri dish with filter paper and add a small amount of sterilized water. Place a glass table of about 5 mm on the filter paper, and place a Cu-coated table on it. 2 O and other glass plates to be tested. 50 μL of a previously purified suspension of Qβ phage (NBRC20012) was dropped thereon, and the surface of the material was covered with an OHP film to bring the phage into contact. Cover the Petri dish with a glass plate. The same measurement set (measurement set) was prepared according to the planned number of measurements of the number of phages, and was left ...

example 2

[0093] The virus inactivation effect for T4 bacteriophage (NBRC20004) was studied in the same manner as Example 1. 2 O for 60 minutes of exposure, the concentration of T4 phage was reduced to 1 / 10 6 ( image 3 ).

example 3

[0095] Using A / PR / 8 / 34 (H1N1), which is an influenza virus, 12-day-old developing eggs were inoculated with a virus liquid, infected, and cultured at 35.5° C. for 2 days. After standing overnight at 4°C, the allantoic fluid (urine) was recovered, and subjected to microfiltration (removal of egg-derived contaminants) and ultrafiltration (removal of impurities and concentration of virus) to obtain a concentrated solution. The concentrate was purified by ultracentrifugation-based sucrose density gradient sedimentation velocity method (5-50% sucrose linear gradient, 141,000×g, 3 hours) to obtain high-purity virus fluid. In order to stabilize the virus, bovine serum albumin (BSA) was added as a stabilizer during the test.

[0096] Use the same method as Example 1 figure 1 The method shown confirms viral inactivation for influenza virus. Preparation of the loaded sample was carried out in the same manner as in Example 1. In the evaluation, a deep petri dish was covered with filte...

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Abstract

A virus inactivator which can exhibit an inactivation activity involving structural disruption such as denaturation or decomposition on viruses, and which comprises a univalent copper compound such as cuprous oxide, cuprous sulfide, cuprous iodide and cuprous chloride as an active ingredient; and a virus-inactivating material which comprises a base material and the virus inactivator on the surface and / or the inside of the base material.

Description

technical field [0001] The present invention relates to a virus inactivating agent which exerts inactivating effects such as modification or decomposition on viruses such as influenza virus. Background technique [0002] It has been known for a long time that silver ions (Ag + ), zinc ions (Zn 2+ ) and divalent copper ions (Cu 2+ ) and other metal ions can inhibit the proliferation of microorganisms or exert a bactericidal effect on microorganisms. A large number of antimicrobial materials loaded with these metal ions on materials such as zeolite or silica gel, and titanium dioxide with photocatalytic effect have been developed. Combination of antimicrobial materials, etc. [0003] Regarding the antimicrobial or antiviral effects of divalent copper ions, it has been clear that there are structural changes and functional destruction of cell membranes (Progress in Medicinal Chemistry, 31, pp.351-370, 1994), and modification of nucleic acids (CRC Critical Rev.Environ.Cont.,...

Claims

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Application Information

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IPC IPC(8): A01N59/20A01N59/16A01P1/00
CPCA01N25/26A01N59/16A01N59/20
Inventor 桥本和仁砂田香矢乃宫内雅浩邱晓清洼田吉信石黑齐中野龙一梶冈实雄姚燕燕
Owner THE UNIV OF TOKYO
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