Drug composition containing micafungin or salt thereof
A technology of micafungin and composition, which is applied in the field of stable pharmaceutical composition of cyclic polypeptide compound micafungin, can solve problems such as unsuitable for pharmaceutical excipients, inability to use excipients, gastrointestinal discomfort, etc., and achieve Excellent stability and safety, few adverse reactions, and stable appearance
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0031]
[0032] Dissolve dextran 70 in pure water (750ml) at room temperature, add micafungin sodium, and let stand or stir gently until the raw drug is completely dissolved. Add an appropriate amount of 0.1 mol / L citric acid aqueous solution and / or 0.1 mol / L sodium hydroxide aqueous solution to the solution to adjust the pH value of the solution to 5.5. Then dilute to 1250ml with pure water. The resulting solution was dispensed into 500 10ml control antibiotic bottles, 2.5ml in each bottle. Freeze-drying was performed by a conventional method to obtain freeze-dried compositions each containing 50 mg of micafungin.
Embodiment 2
[0034]
[0035] Dissolve dextran 20 and sucrose in 750ml of pure water at room temperature, then add micafungin sodium, and let stand or stir gently until the raw drug is completely dissolved. An appropriate amount of 0.1 mol / L hydrochloric acid solution and / or 0.1 mol / L aqueous sodium hydroxide solution was added to the solution to adjust the pH value of the solution to 5.5. Then dilute to 1250ml with pure water. The resulting solution was dispensed into 500 10ml control antibiotic bottles, 2.5ml in each bottle. Freeze-drying was performed by a conventional method to obtain freeze-dried compositions each containing 50 mg of micafungin.
Embodiment 3
[0037]
[0038] Dissolve dextran 40 and sucrose in 750ml of pure water at room temperature, then add micafungin sodium, and let stand or stir gently until the raw drug is completely dissolved. Add an appropriate amount of 0.1 mol / L citric acid aqueous solution and / or 0.1 mol / L sodium hydroxide aqueous solution to the solution to adjust the pH value of the solution to 5.5. Then dilute to 1250ml with pure water. The resulting solution was dispensed into 500 10ml control antibiotic bottles, 2.5ml in each bottle. Freeze-drying was performed by a conventional method to obtain freeze-dried compositions each containing 50 mg of micafungin.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com