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Controllable fully-degradable macromolecular material-based composite material and preparation method thereof

A technology of polymer materials and composite materials, which is applied in the field of controllable and fully degradable polymer material-based composite materials and their preparation, and achieves the effect of high biological safety.

Inactive Publication Date: 2013-08-28
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a controllable fully degradable polymer material-based composite material and its preparation method in view of the main problems existing in the existing biomedical materials and their application technologies

Method used

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  • Controllable fully-degradable macromolecular material-based composite material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] First prepare 25g / L PLLA solution with chloroform as solvent, then add 5g / L magnesium hydroxide powder, stir mechanically for 1h to obtain a suspension with magnesium hydroxide as solid dispersed phase and PLLA organic solvent-based solution as liquid. The suspension was cast on a clean glass sheet, and dried in a vacuum drying oven at a controlled temperature of 60° C. for 48 hours, and a film-like composite material was obtained after the solvent was completely evaporated. After crushing the above-mentioned film-like composite material, it was hot-pressed (hot-pressing temperature 175°C, pressure 17MPa) to obtain a hydrogen oxide film with a size of 20mm×10mm×2.5mm and an amount of magnesium hydroxide added to the mass fraction of the composite material of 16.67%. Magnesium / PLLA bulk composite specimen.

[0024] Take SBF (simulated body fluid) as the test medium (see Table 1 for the comparison between its composition and the chemical composition of human plasma), and ...

Embodiment 2

[0026] Except that PLLA is changed to PLGA, magnesium hydroxide is changed to magnesium oxide, and organic solvent is changed to dichloromethane, the other conditions for composite material preparation are the same as in Example 1. As a result, the amount of magnesium oxide added accounts for 16.67% of the composite material mass fraction. MgO / PLGA bulk composites. The in vitro biodegradability test was carried out on the sample as in Example 1. The results of mass change monitoring show that the time required for the complete degradation of the composite material sample and the pure PLGA control sample is 140d and 94d respectively; The pH change of the test medium due to degradation was 1.23 higher than that of the pure PLGA control sample, which confirmed that the acidification effect produced by the degradation process of the polymer material was significantly weakened by the addition of magnesium oxide.

Embodiment 3

[0028] Except changing the 5g / L magnesium hydroxide into a mixture of 5g / L magnesium oxide and 5g / L magnesium hydroxide, and changing the organic solvent into epichlorohydrin, the other conditions for the preparation of the composite material are controlled the same as in Example 1, and the result is an oxidized The mass fraction of magnesium and magnesium hydroxide accounted for 14.29% of the bulk composite material. The in vitro biodegradability test was carried out on the sample as in Example 1. The results of mass change monitoring show that the time required for the complete degradation of the composite sample and the pure PLLA control sample is 178d and 82d respectively; The pH change of the test medium due to degradation was 1.97 higher than that of the pure PLLA control sample, which confirmed that the acidification effect produced by the degradation process of polymer materials was significantly weakened by the addition of magnesium oxide and magnesium hydroxide.

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Abstract

The invention relates to a controllable fully-degradable macromolecular material-based composite material and a preparation method thereof. According to the controllable fully-degradable macromolecular material-based composite material, a degradable macromolecular material serves as a matrix; magnesium oxide, magnesium hydroxide or a mixture of magnesium oxide and magnesium hydroxide serves as an enhanced phase; and the adding amount of the magnesium oxide, magnesium hydroxide or the mixture of magnesium oxide and magnesium hydroxide accounts for 0.5-40wt% of the composite material. The controllable fully-degradable macromolecular material-based composite material has the characteristics of high biosecurity, good degradation controllability, low material cost and the like, and has a wide application prospect in the technical field of manufacturing or surface modification of medicine controlled release carriers (such as medicinal capsules) and medical treatment appliance products, especially high-additional-value implants comprising 1) surgical sutures, 2) orthopedic internal fixation devices such as bone plates, bone nails, bone nets and the like, 3) artificial bone or bone repair materials, 4) intravascular stents, 5) tissue engineering stents and the like.

Description

technical field [0001] The invention belongs to the technical field of manufacturing and application of biomedical new materials and medical device products, and in particular relates to a controllable fully degradable polymer-based composite material and a preparation method thereof. Background technique [0002] With the development of social economy and the improvement of living standards, human beings are paying unprecedented attention to their own medical and health undertakings. The increasing pressure of survival, the accelerated pace of life, the intensification of environmental pollution, the frequent occurrence of food, transportation and production safety accidents, local wars, and natural disasters have caused diseases and traumas to become the ever-lingering haze of human beings. As an important means of modern medicine—an important basis and component of medical devices, biomaterials are used for the diagnosis and treatment of diseases, the repair, replacement ...

Claims

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Application Information

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IPC IPC(8): C08L67/04C08K3/22
Inventor 张永君贾书功沈军夏兰梅董连军李爱红陶胜
Owner SOUTH CHINA UNIV OF TECH
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