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A kind of production method of colistin sulfate

A technology of colistin sulfate and production method, applied in the production field of colistin sulfate, can solve the problems of high concentration cost, low overall yield, low purity, etc., and achieves low valve switching frequency, simplified system and good operability Effect

Active Publication Date: 2015-10-07
XIAMEN STARMEM TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although this method does not use solvents in the whole process, which reduces environmental pollution, the method of precipitation separation leads to low overall yield, low purity and high concentration cost.

Method used

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  • A kind of production method of colistin sulfate
  • A kind of production method of colistin sulfate
  • A kind of production method of colistin sulfate

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Embodiment

[0040] Example: The raw material liquid is colistin fermentation liquid pretreated by ceramic membrane and decalcified process, the material liquid is dark brown, the titer of colistin is between 350,000-400,000 u / ml, Ca 2+ Content≤200ppm. The amount of resin filled in each separation unit is 450mL, and the rotation cycle of the equipment is 2100s or 35min. The flow rate of the resin=450 / 35=12.8mL / min, and the feeding amount of the fermentation broth is about 138mL. The amount of resin used can be characterized by the ratio of resin volume to feed volume, that is, 12.8:138 = 1:10.8. In the case of 2100S / rev, the amount of feed liquid that can be processed by a unit of resin is: 10.8ml feed liquid / ml resin; Methods The results of colistin sulfate production are shown in the table below.

[0041]

[0042] It can be seen from the above table that after the raw material solution is treated by the continuous ion exchange system, the product titer is about 1.6 million u / ml, and...

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Abstract

The invention discloses a colistin sulfate production method, which sequentially comprises the following steps: filtering, calcium and magnesium removing-absorption desorption, concentration, desalting, neutralization and spray drying, and is characterized in that the filtering adopts ceramic membrane ultra-filtration filtering, the absorption desorption adopts a continuous ion exchange system filled with a methacrylic acid type carboxylic acid base resin or an acrylic acid carboxylic acid base resin to carry out absorption desorption, and the concentration adopts nano-filtration concentration. The production method has the following advantages that: colistin sulfate is an intracellular product, and cells can be broken when filtration is performed by using a ceramic membrane, such that the colistin sulfate in the colistin sulfate cells can be collected; the equipment is compact, the system is simplified, the pipeline is reduced, and the occupation area is small; the resin consumption is reduced; and the adopted nano-filtration has advantages of high concentration ratio, low energy consumption and the like, and the whole method has advantages of high yield, good purification effect, low production cost and the like.

Description

technical field [0001] The invention relates to the field of colistin sulfate production, in particular to a production method of colistin sulfate. Background technique [0002] Colistin is a polypeptide antibiotic with specific resistance to multidrug-resistant Granz-negative pathogenic bacteria (such as Pseudomonas aeruginosa). Myxobacterium contains diaminobutyric acid and free amino groups , so it is alkaline, and it is often made into salt for clinical use. Currently, it is commercialized in two forms, and colistin sulfate (colistin sulphate, CS) is one of the forms. Colistin sulfate can be used in animals such as pigs, poultry, cattle, and sheep. Because of its strong antibacterial effect, low residue, and low resistance, it is approved as a feed additive or veterinary drug by many countries such as China, the United States, the European Union, and Japan. It can treat animal feeding diseases caused by a variety of germs, and can promote animal biology and improve feed...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/62C07K1/36C07K1/34C07K1/18
Inventor 彭广生卢伯福陈洪景虞美辉李振峰雷细良
Owner XIAMEN STARMEM TECH
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