Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Colistin sulfate production method

A technology of colistin sulfate and production method, applied in the field of production of colistin sulfate, can solve the problems of low overall yield, high concentration cost, low purity and the like, achieve system simplification, low valve switching frequency and good operability Effect

Active Publication Date: 2013-08-28
XIAMEN STARMEM TECH
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method does not use solvents in the whole process, which reduces environmental pollution, the method of precipitation separation leads to low overall yield, low purity and high concentration cost.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Colistin sulfate production method
  • Colistin sulfate production method
  • Colistin sulfate production method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0040] Embodiment: The raw material liquid is colistin fermentation liquid pretreated by ceramic membrane and decalcified process, the raw material liquid is dark brown, the titer of colistin is between 350,000-400,000 u / ml, and the Ca2+ content is ≤200ppm. The amount of resin filled in each separation unit is 450mL, and the rotation cycle of the equipment is 2100s or 35min. The flow rate of the resin = 450 / 35 = 12.8mL / min, and the feeding amount of the fermentation broth is about 138mL. The amount of resin can be characterized by the ratio of resin volume to feed volume, that is, 12.8:138=1:10.8. In the case of 2100S / rev, the amount of feed liquid that can be processed by a unit of resin is: 10.8ml feed liquid / ml resin; Methods The results of colistin sulfate production are shown in the table below.

[0041]

[0042] It can be seen from the above table that after the raw material solution is treated by the continuous ion exchange system, the product titer is about 1.6 mil...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a colistin sulfate production method, which sequentially comprises the following steps: filtering, calcium and magnesium removing-absorption desorption, concentration, desalting, neutralization and spray drying, and is characterized in that the filtering adopts ceramic membrane ultra-filtration filtering, the absorption desorption adopts a continuous ion exchange system filled with a methacrylic acid type carboxylic acid base resin or an acrylic acid carboxylic acid base resin to carry out absorption desorption, and the concentration adopts nano-filtration concentration. The production method has the following advantages that: colistin sulfate is an intracellular product, and cells can be broken when filtration is performed by using a ceramic membrane, such that the colistin sulfate in the colistin sulfate cells can be collected; the equipment is compact, the system is simplified, the pipeline is reduced, and the occupation area is small; the resin consumption is reduced; and the adopted nano-filtration has advantages of high concentration ratio, low energy consumption and the like, and the whole method has advantages of high yield, good purification effect, low production cost and the like.

Description

technical field [0001] The invention relates to the field of colistin sulfate production, in particular to a production method of colistin sulfate. Background technique [0002] Colistin is a polypeptide antibiotic with specific resistance to multidrug-resistant Granz-negative pathogens (such as Pseudomonas aeruginosa). Myxobacterium contains diaminobutyric acid and free amino groups , so it is alkaline, and it is often used as a salt in clinical practice. Currently, it is commercialized in two forms, and colistin sulfate (colistin sulphate, CS) is one of the forms. Colistin sulfate can be used in animals such as pigs, poultry, cattle, and sheep. Because of its strong antibacterial effect, low residue, and low resistance, it is approved as a feed additive or veterinary drug by many countries such as China, the United States, the European Union, and Japan. It can treat animal feeding diseases caused by a variety of germs, and can promote animal biology and improve feed utili...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07K7/62C07K1/36C07K1/34C07K1/18
Inventor 彭广生卢伯福陈洪景虞美辉李振峰雷细良
Owner XIAMEN STARMEM TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com