Plasma exchanging adsorption filtration purification system provided with plasma storage bag and application method of purification system

Abstract

The invention discloses a plasma exchanging adsorption filtration purification system provided with a plasma storage bag and an application method of the purification system. The method includes two steps of plasma components separation returning cycle and high-speed plasma purification regeneration cycle. Plasma components are separated by a selective membrane plasma separator; flow speed difference between a plasma separation cycle and a plasma purification circle is set by the specific plasma storage bag; high-speed plasma adsorption filtration purification treatment is performed by a high-throughput filter and an active carbon-resin absorptive device in a purification circle; and plasma subjected to cycle treatment for multiple times can be exchanged back to a human body through the separation returning circle. By the aid of the purification system and the application method thereof, autologous plasma waste generated in a plasma exchanging purification process can be purified continuously and effectively, and plasma consumption is reduced. The high-throughput filter and an adsorption column are connected in series to purify the plasma; load on a subsequent adsorber is reduced; and varied inflammatory factors, macromolecular toxins and the like combined by micromolecules, middle molecules and proteins which are generated from hepatic failure are eliminated as well, so that the purification efficiency of the whole system is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, relates to a medical device and an application method thereof, in particular to a blood purification system which adopts a combination of replacement, adsorption and filtration technologies and an application method thereof. Background technique [0002] The blood purification technology for artificial liver replacement therapy is developing rapidly. At present, the domestic treatment is dominated by component plasma exchange, while the research hotspot abroad is the albumin dialysis adsorption system. The representative method is the molecular adsorption recirculation system (MARS). The basic principle of this type of method is to use albumin solution as the dialysate in the protein dialysis cycle, so that the protein-bound toxins and other types of toxin molecules in the patient's blood are transferred to the albumin solution through the MARS dialysis membrane, so that the blood can be...

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Problems solved by technology

This system is improved on the basis of the MARS system, but still uses the albumin dialysis method of MARS, and the exchange efficiency of the membrane is too low. Even if the subsequent purification method is improved, the purification effect is still limited

[0004] The Prometheus system, which is similar to the MARS treatment system, separates and absorbs the component plasma and then performs hemodiafiltration. Compared with the MARS system, the amount of albumin is greatly reduced, but the plasma separator is connected in series with the hemofilter, which greatly increases the system cost. Operational instability, difficult clinical operation, and extracorporeal circulation capacity of at least 600ml, have a great impact on the hemodynamics of critically ill patients, so it has not been widely used at home and abroad

[0005] Domestically, the method of plasma exchange is widely used. At present, the supply of plasma is extremely short, and a plasma exchange needs to use about 3000ml of fresh plasma, and the replaced 3000ml of plasma is discarded, and a large number of beneficial components cannot be effectively reinfused and utilized. At present, there is no efficient way to recycle these waste plasma. If the waste plasma can be fully utilized for purification and then replaced by itself, it can greatly reduce the amount of clinical plasma used and effectively treat more patients.

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