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Anti-adhesion surgical patch and preparation method thereof

An anti-adhesion and surgical technology, applied in medical science, surgery, etc., can solve the problems that it is difficult to ensure the normal repair of damaged organs, cannot be completely degraded, will remain in the body as a permanent foreign body, and degrade too quickly, etc., to achieve inhibition Effects of exogenous repair, prevention of adhesion reaction, and prevention of invasion

Active Publication Date: 2013-08-14
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is difficult to ensure the normal repair of damaged organs without the use of anti-adhesion film
Therefore, an anti-adhesion film will be used during the operation. There are two types of anti-adhesion films: one is a synthetic polymer film, which cannot be completely degraded in the human body and will remain in the body as a permanent foreign body. Middle; the second is the pure natural collagen membrane material, the disadvantage of this material is that it degrades too quickly, especially in places rich in body fluids or blood, it often degrades before the damaged organs are healed, resulting in only the prevention stage The occurrence of permanent adhesion reaction, when the degradation of the collagen material is complete, the adhesion reaction will still occur in the damaged organ

Method used

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  • Anti-adhesion surgical patch and preparation method thereof
  • Anti-adhesion surgical patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1. Preparation of anti-adhesion surgical patch

[0031] 1. Collect the uterus of pigs that have just been slaughtered from a standardized management slaughter plant, try to avoid contact with contaminants, and freeze and store immediately after collection.

[0032] 2. Thaw and clean the uterus obtained in step 1, trim and remove the parts that are not easy to process.

[0033] 3. The first alkali treatment

[0034] The product of step 2 is soaked in an alkaline solution.

[0035] The purpose of this step is to denature, hydrolyze, and dissolve the non-collagen protein in the membrane tissue.

[0036] Specific steps: Use 2M NaOH aqueous solution, 6±2℃ soak for 60 minutes, then wash with water.

[0037] 4. Surfactant treatment

[0038] The product of step 3 is immersed in a surfactant solution.

[0039] The purpose of this step is to destroy the cell membrane structure and break the cells to dissolve.

[0040] Specific steps: Use 0.5g / 100ml TritonX-100 aqueous solution to soak a...

Embodiment 2

[0054] Example 2. Preparation of anti-adhesion surgical patch

[0055] 1. Collect the uterus of the cattle that has just been slaughtered from a standardized management slaughter plant, try to avoid contact with contaminants, and freeze and store immediately after collection.

[0056] 2. Thaw the uterus obtained in step 1 and wash it thoroughly, trim and remove the parts that are not easy to process.

[0057] 3. The first alkali treatment

[0058] The product of step 2 is soaked in an alkaline solution.

[0059] The purpose of this step is to denature, hydrolyze, and dissolve the non-collagen protein in the membrane tissue.

[0060] Specific steps: Use 0.5M KOH aqueous solution, 2±2℃ soak for 70min, then wash with water.

[0061] 4. Surfactant treatment

[0062] The product of step 3 is immersed in a surfactant solution.

[0063] The purpose of this step is to destroy the cell membrane structure and break the cells to dissolve.

[0064] Specific steps: Use 1g / 100ml Tween-80 aqueous solution ...

Embodiment 3

[0078] Example 3. Preparation of anti-adhesion surgical patch

[0079] 1. Collect the peritoneum of pigs that have just been slaughtered from a standardized management slaughter plant, try to avoid contact with pollutants, and freeze and store immediately after collection.

[0080] 2. Thaw the peritoneum obtained in step 1 and wash it thoroughly, trim and remove the parts that are not easy to process.

[0081] 3. The first alkali treatment

[0082] The product of step 2 is soaked in an alkaline solution.

[0083] The purpose of this step is to denature, hydrolyze, and dissolve the non-collagen protein in the membrane tissue.

[0084] Specific steps: use 0.2M Ca(OH) 2 Aqueous solution, immerse at 23±2℃ for 90min, then wash with water.

[0085] 4. Surfactant treatment

[0086] The product of step 3 is immersed in a surfactant solution.

[0087] The purpose of this step is to destroy the cell membrane structure and break the cells to dissolve.

[0088] Specific steps: Use 3g / 100ml Tween-40 aque...

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Abstract

The invention discloses an anti-adhesion surgical patch and a preparation method thereof. The preparation method of the anti-adhesion surgical patch comprises the following steps: (1) soaking isolated animal peritoneal tissues by utilizing aqueous alkali; (2) soaking a product in the step (1) by utilizing a surfactant solution; (3) soaking a product in the step (2) by adopting the aqueous alkali; (4) soaking a product of the step (3) by using an irradiation protection reagent solution with the pH of 5.8-7.8; (5) soaking a product in the step (4) by utilizing a phosphate buffered saline (PBS) buffer solution; and (6) sequentially carrying out freeze drying and irradiation sterilization on a product in the step (5), thus obtaining the anti-adhesion surgical patch. The surgical patch provided by the invention is of a natural double-layer membrane structure, can effectively prevent adhesion reaction from being caused, can ensure that endogenous repair to the maximum extent and successfully inhibits exogenous repair.

Description

Technical field [0001] The invention belongs to the field of implanted medical devices, and specifically relates to an anti-adhesion surgical patch used in surgical operations and a preparation method thereof. Background technique [0002] In modern surgery, after tissue resection or partial resection, meningeal injury repair, tendon injury repair and other operations, adhesion reactions are prone to occur. [0003] The repair of injured tissues is divided into two ways: endogenous repair and exogenous repair: if the nutrient supply is sufficient and the quality of the anastomosis is high, it is endogenous healing, which rarely occurs adhesion; on the contrary, exogenous healing is dominant , A lot of adhesions will occur around the repaired tissue. [0004] The endogenous healing of the tissue must be based on a good nutritional state of the tissue. However, after middle age, the self-repairing ability and supporting ability of tissues will be weakened. In addition, some tissues a...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/14
Inventor 孙先昌郭松董佳桓李垠埔彭继学
Owner YANTAI ZHENGHAI BIO TECH
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