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Enramycin premix preparation method

A technology of duscarcin and premix, which is applied in the field of preparation of premix, can solve the problems of unfavorable storage and transportation of powder, large environmental pollution, large energy consumption, etc., and achieves enhanced market competitiveness and environmental friendliness. , the effect of reducing waste

Inactive Publication Date: 2013-08-07
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are two main production processes for this product: one is to refine the duramycin fermentation liquid through crude extraction of solvent and super-macroporous resin to obtain the pure duramycin, and then add auxiliary materials to prepare the duramycin premix agent, this method has the problems of using a large amount of organic solvents and acid-base solvents, high cost, and large environmental pollution; the second is to filter the duramycin fermentation liquid with a plate frame, spray dry it, and then add a carrier to obtain the duramycin Premix powder, the operation of this method contains a lot of water, which will generate a lot of energy consumption when drying, and the powder prepared by it has disadvantages such as being unfavorable for storage and transportation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Control the temperature of the fermented duramycin fermentation broth at 50°C, adjust the pH range to 7 with a sodium hydroxide solution with a mass concentration of 40%, pass through a 120-7 filter cloth for plate and frame pressure filtration, filter aid It is perlite, and the weight-to-volume ratio of the filter aid to the fermentation broth is 2g / mL to obtain the duramycin filter cake;

[0021] (2) The filter cake obtained in step (1) was flash-dried for 15 minutes under the conditions of controlling the inlet air temperature at 180°C, the outlet air temperature at 60°C, and the material temperature at 80°C, and then pulverized to obtain persistent mold Vegetable thallus powder, the mass content of duramycin is determined to be 32%;

[0022] (3) Combine 25 parts by weight of the duramycin cell powder obtained in step (2) with 24 parts by weight of sodium dodecylbenzenesulfonate, 38 parts by weight of zeolite powder, and 13 parts by weight of rice husks that have...

Embodiment example 2

[0026] (1) Control the temperature of the fermented duramycin fermentation broth at 55°C, adjust the pH range to 7.5 with 50% sodium hydroxide solution, pass through a 120-7 filter cloth for plate and frame filtration, filter aid It is diatomaceous earth, and the weight-to-volume ratio of filter aid and fermented liquid is 4g / mL, obtains duramycin cell filter cake;

[0027] (2) The filter cake obtained in step (1) was flash-dried for 20 minutes under the conditions of controlling the inlet air temperature at 183°C, the outlet air temperature at 65°C, and the material temperature at 85°C, and then pulverized to obtain persistent mold Vegetable thallus powder, the mass content of duramycin is determined to be 40%;

[0028] (3) Mix 20 parts by weight of the duramycin cell powder obtained in step (2) with 25 parts by weight of water glass, 38 parts by weight of zeolite powder, and 17 parts by weight of rice husk powder that have all passed through an 80-mesh sieve, and then add 2...

Embodiment example 3

[0032] (1) Control the temperature of the fermented duramycin fermentation broth at 60°C, adjust the pH range to 8 with a potassium hydroxide solution with a mass concentration of 40%, pass through a 120-8 filter cloth for plate and frame filtration, filter aid It is light calcium carbonate, and the weight-to-volume ratio of the filter aid to the fermentation broth is 7g / mL to obtain the duramycin cell filter cake;

[0033] (2) The filter cake obtained in step (1) was flash-dried for 25 minutes under the conditions of controlling the inlet air temperature at 185°C, the outlet air temperature at 70°C, and the material temperature at 90°C, and then pulverized to obtain persistent mold Vegetable cell powder, the mass content of duramycin is determined to be 16%;

[0034] (3) Combine 50 parts by weight of the duramycin cell powder obtained in step (2) with 15 parts by weight of sodium dodecylbenzenesulfonate, 24 parts by weight of ground calcium carbonate, 11 parts by weight of al...

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Abstract

The invention discloses a preparation method of an enramycin premix. The method comprises the specific steps that: an eramycin fermentation broth is subjected to plate frame pres filtration, flash drying, and crushing; a carrier is added, and the mixture is well mixed; and granulation, drying, and sieving are carried out, such that the enramycin premix is obtained. According to the invention, granulation rate and yield of the obtained eramycin premix are greatly improved, titer stability is substantially improved, and effective component wasting is reduced. The process is simple to operate, and cost is greatly reduced. The method is suitable for industrial production, and is environment-friendly.

Description

technical field [0001] The invention relates to a preparation method of a duramycin premix, in particular to a new process for preparing a duramycin premix granule by utilizing a duramycin fermentation broth, and belongs to the field of biopharmaceutical engineering. Background technique [0002] Enramycin is a polypeptide antibiotic, also known as enramycin, anlemycin, and enramycin. It is a white or slightly yellow powder with a molecular weight of about 2500 and a melting point of 225-240°C. Soluble in dilute hydrochloric acid and dimethylformamide, soluble in methanol and hydrous ethanol, insoluble in acetone, insoluble in acetic acid, benzene, and chloroform. Duramycin is a giant lactone ring composed of seventeen monomers of twelve amino acids, and the fatty acid side chain is connected to the lactone ring through an amide bond. Permacin is divided into Permacin A (C 107 h 138 C l2 N 26 o 31 ) and persistent mycin B (C 108 h 140 C l2 N 26 o 31 ), the differe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/10A61K9/16A61P31/04
Inventor 胡永红孟中斌杨文革开玉美沈飞马小平朱文俊殷晶晶徐瑞华
Owner NANJING UNIV OF TECH
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