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Chinese date leaf extractive and application thereof in preparation of medicament or health food for preventing and treating liver injury

A technology of jujube leaves and extracts, applied in the preparation of drugs or health care products for preventing and treating liver damage, in the field of extraction of jujube leaf extracts, can solve the problems of limited use, serious side effects, inconvenient use, etc., and achieve energy consumption The effect of less, high content of active ingredients, and low adverse reactions

Active Publication Date: 2013-06-26
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently commonly used liver-protecting drugs in clinical practice are limited in use due to high price, inconvenient use, or relatively large side effects.
At present, there is no technology to prepare active extracts from jujube leaves, and there is no report on using jujube leaves as a main component to prevent and treat liver damage.

Method used

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  • Chinese date leaf extractive and application thereof in preparation of medicament or health food for preventing and treating liver injury
  • Chinese date leaf extractive and application thereof in preparation of medicament or health food for preventing and treating liver injury
  • Chinese date leaf extractive and application thereof in preparation of medicament or health food for preventing and treating liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The active extract of jujube leaves for preventing and treating liver damage is prepared by the following method:

[0030] (1) Take jujube leaves, sort, wash, and dry, weigh 10kg, put them into an extraction tank, add 10 times the amount of 80% ethanol, heat and reflux 3 times, each time for 2h, filter, combine the extracts, and concentrate to After no alcohol smell, get the alcohol extract (2L) of jujube leaves for later use;

[0031] (2) get the jujube leaf ethanol extract that step (1) obtains, add 2 times amount of water, add after mixing and be 50 centimetres, in the D101 macroporous adsorption resin chromatographic column of height 1.5 meters through the activation, pre- After 12 hours of adsorption, the water, 10% ethanol and 90% ethanol were respectively eluted at a rate of 2BV / h, and the elution volume was 50L. The 90% ethanol eluate was collected, concentrated until no alcohol smell, and the jujube leaves were obtained. Crude extract of active part 1L, set as...

Embodiment 2

[0035] The active extract of jujube leaves for preventing and treating liver damage is prepared by the following method:

[0036] (1) Take jujube leaves, sort, wash, and dry, weigh 10kg, put them into an extraction tank, add 10 times the amount of 70% ethanol, heat and reflux 3 times, each time for 2h, filter, combine the extracts, and concentrate to After no alcohol smell, get the alcohol extract (2.5L) of jujube leaves for later use;

[0037] (2) Get the jujube leaf ethanol extract that step (1) obtains, add 1.5 times of water, add after mixing and be 50 centimetres, in the AB-8 macroporous adsorption resin chromatographic column of height 1.5 meters through the activation , after pre-adsorption for 12 hours, eluted with water, 10% ethanol and 85% ethanol at a speed of 2BV / h respectively, the elution volume was 50L, collected 85% ethanol eluate, concentrated until no alcohol smell, and obtained large Crude extract of active parts of jujube leaves 1L, set aside;

[0038] (3...

Embodiment 3

[0041] The active extract of jujube leaves for preventing and treating liver damage is prepared by the following method:

[0042] (1) Take jujube leaves, sort, wash, and dry, weigh 10kg, put them into an extraction tank, add 8 times the amount of 90% ethanol, heat and reflux twice, each time for 2h, filter, combine the extracts, and concentrate to After no alcohol smell, get the alcohol extract (1.6L) of jujube leaves for later use;

[0043] (2) Get the jujube leaf ethanol extract that step (1) obtains, add 3 times of water, add after mixing and be 50 centimetres, in the HP-20 macroporous adsorption resin chromatographic column of high 1.5 meters through the activation After pre-adsorption for 12 hours, water, 10% ethanol and 95% ethanol were respectively eluted at a rate of 2BV / h, and the elution volume was 50L. The 95% ethanol eluate was collected and concentrated until it had no alcohol smell. Crude extract of active parts of jujube leaves 1L, set aside;

[0044] (3) Get ...

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Abstract

The invention discloses a Chinese date leaf extractive and an application thereof in preparation of a medicament or health food for preventing and treating liver injury. The way that macroporous resin is coupled with polyamide resin and then a fine Chinese date leaf extractive is prepared through a preparative liquid phase is firstly adopted; compared with the traditional separation and purification method, the way has the advantages that the separation efficiency is higher, the active component obtained through separation is higher in content, strong in biological activity and high in safety. Experiment researches show that the Chinese date leaf extractive can be used for remarkably reducing the activities of ALT (Alanine Transaminase) and AST (Aspartate Transaminase) in serum of a model mouse with liver injury caused by CCl4, D-GalN and ethanol and the content of MDA (Methyl Di Aldehyde) in liver tissues and enhancing the activity of SOD (Superoxide Dismutase) of the liver and has favorable preventing and treating effects. Therefore, Chinese date leaves and the Chinese date leaf extractive are expected to be developed into a new-generation safe and effective medicament or health food for preventing and treating liver injury, and meanwhile, an approach is also provided for turning the waste Chinese date leaf resource into the things of value and comprehensively utilizing a date tree resource.

Description

technical field [0001] The invention relates to a plant extract extraction technology and its application, in particular to the extraction technology of jujube leaf extract and its application in the preparation of medicines or health care products for preventing and treating liver damage. Background technique [0002] The liver is one of the most important organs in the body, and liver disease is a relatively common clinical disease. Therefore, liver disease has always been one of the key research objects of medical science. Liver injury is a pathological state with outstanding characteristics shared by many liver diseases, which seriously threatens human health. Various harmful factors such as drugs, viruses, alcohol, organisms, etc. may cause liver function to be damaged to varying degrees, thereby reducing liver detoxification, excretion function, reserve and regeneration capacity, reducing liver blood flow, and aggravating metabolic load, resulting in endogenous diseas...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61P1/16A23L1/29A61K127/00A23L33/00
Inventor 郭盛段金廒钱大玮宿树兰
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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