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Application of letrozole (LE) in preparation of drug used for causing adult cattle to excessively ovulate

A technology of superovulation and letrozole, applied in letrozole in the preparation of superovulation drugs for adult cattle, in the field of superovulation, it can solve the problems of no research reports on the superovulation scheme of cattle, and achieve accelerated Improved breed selection and multiplication technology system, short half-life, and the effect of promoting bovine follicle development

Active Publication Date: 2013-06-26
CHINA AGRI UNIV
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Problems solved by technology

Therefore, in view of the similarity of bovine and human reproductive physiological characteristics, it is speculated that the combination of LE and FSH in superovulation will have a certain effect, but there is no research report on the improvement of bovine superovulation protocol

Method used

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  • Application of letrozole (LE) in preparation of drug used for causing adult cattle to excessively ovulate

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Embodiment 1

[0023] In the present invention, FSH is used in a traditional superovulation scheme for adult cows and LE is taken orally, and the optimal dosage of LE for cattle is determined through oral administration of different doses of LE. FSH was injected twice a day for 4 days at 8:00 in the morning and 8:00 in the evening. 24 hours after the first FSH injection, that is, the third injection of FSH was treated with different doses of LE (0.1 mg, 0.2 mg, 0.4 mg and 0.8mg / kg body weight), while no LE treatment was used as the control; embryos collected after superovulation and artificial insemination were implanted into recipient cows with obvious estrus performance after estrus synchronous treatment by embryo transfer technology, and the embryos after implantation Calving through full development.

[0024] Specifically, the bovine superovulation scheme using Letrozole of the present invention:

[0025] (1) Follicular synchronous development treatment: select adult Holstein cows (10 c...

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Abstract

The invention provides an application of letrozole (LE) in preparation of a drug used for causing an adult cattle to excessively ovulate. According to the invention, LE is added in the traditional adult cattle superovulation scheme, and follicular development is promoted by utilizing influence of letrozole on internal secretion and paracrine and an ovary follicle collecting effect, so that quantity of available ovocyte is increased; besides, a half-life period of letrozole is shorter, metabolism velocity is high, no side effect is produced, and letrozole can serve as a livestock superovulation auxiliary drug to be popularized and applied in animal husbandry production.

Description

technical field [0001] The present invention relates to a novel superovulation method, in particular to the application of letrozole in the preparation of superovulation medicine for adult cattle, which can be used to produce transgenic cloned livestock and livestock breeding by utilizing superovulated oocytes and protection of endangered species. The invention belongs to the field of applied embryo biotechnology. Background technique [0002] Superovulation technology was originally discovered with rodent experimental animals as the research object. A large number of oocytes were obtained by implanting the anterior pituitary gland material or injecting pregnant horse serum, which laid the foundation for superovulation technology. The most important link in technology. Using superovulation technology can maximize the use of ovarian resources, obtain a large number of neat and high-quality eggs, give full play to the reproductive potential of excellent female animals, and p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4196A61P15/08A61K38/24
Inventor 田见晖贾振伟吴中红张家新安磊
Owner CHINA AGRI UNIV
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