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Reticular tissue engineering scaffold

A reticular tissue and engineering technology, applied in medical science, muscles, ligaments, etc., can solve problems such as poor mechanical properties, difficult clinical practice, and inability to withstand the physiological and mechanical forces of the body, and achieve good mechanical properties, easy access, mechanics and biology. Excellent academic performance

Inactive Publication Date: 2013-06-19
XIAN REJE BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These scaffolds solve the problem of cell tissue accommodation, but their mechanical properties are poor and cannot bear the physiological mechanical force of the body, so it is difficult to apply clinically

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weave thick silk into a net-like scaffold, and then boil it with 0.5% sodium carbonate solution for 90 minutes. The bone marrow mesenchymal stem was planted on the silk scaffold after desericin removal, and electron microscope observation after 7 days of culture showed that the cells could grow well on the scaffold.

Embodiment 2

[0026] The scaffold obtained in Example 1 was seeded with mesenchymal stem cells, and the obtained composite scaffold was seeded with fibroblasts, and cultured in vitro statically or dynamically for 2-8 weeks, it was found that the cells secreted extracellular matrix components to form sheet-like tissue engineered soft tissues. It can be rolled or folded thick to form strip-shaped tissue engineering tendons and ligaments.

Embodiment 3

[0028] Fill the mesh of the stent obtained by boiling for 90 minutes in Example 1 with collagen glue, and then freeze-dry it with a lyophilizer to obtain silk as the frame, and the collagen sea surface is filled with good mechanics and sufficient cell attachment surface. Composite bracket.

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PUM

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Abstract

The invention discloses a reticular tissue engineering scaffold, which is characterized in that: it is mainly woven from sericin removed silk, the mesh size is 0.5-20mm<2>, and the composite biomaterial in the meshes is any of collagen, a medical polyester polymer synthetic material, chitosan, hyaluronic acid, and chondroitin sulfate. The reticular structure of the scaffold provided in the invention has both good mechanical properties and enough interlinked cell tissue accommodation space. The employed materials are easy to obtain, and have excellent mechanical and biological properties. The scaffold also has sufficient pores and good mechanical properties, and is suitable for repair and tissue engineering of ligaments, tendons, abdominal walls, pelvic floors and other tensile tissues.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering, and in particular relates to a mesh tissue engineering support. Background technique [0002] Connective tissue injuries such as tendons and ligaments in shoulders, knees, elbows and other joints account for more than 50% of sports injuries. Due to lifestyle changes, chronic use of keyboards for typing and sending text messages on mobile phones leads to an 8% increase in the number of tendon injuries in the hands each year. Statistics show that there are at least tens of millions of tendon injury cases per 200 million people a year. In addition, as the population age increases, more and more patients suffer from loose or defective soft tissues such as the abdominal wall and basin. [0003] At present, the injuries of tendons and ligaments and the relaxation of abdominal wall and basin tissues are mainly repaired and strengthened by autologous or allogeneic tissues, or by non-degradab...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/40A61F2/08A61F2/02
Inventor 孙叶芳
Owner XIAN REJE BIOLOGICAL TECH
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