In vivo temperature measuring method and system based on alternating magnetization intensity of magnetic nanoparticles

Abstract

The invention discloses an in vivo temperature measuring method based on alternating magnetization intensity of magnetic nanoparticles and belongs to the technical field of nanometer testing. The method comprises the steps of putting a magnetic nanometer reagent at the position of a to-be-tested object, applying an alternating excitation field to an area of the magnetic nanometer reagent, collecting the alternating magnetization intensity of the magnetic nanometer reagent under action of the alternating excitation field, detecting all odd harmonic amplitudes in an alternating magnetization intensity signal, and finally calculating an in vivo temperature according to a relation of a harmonic and the temperature. The relation of all the odd harmonics and the in vivo temperature is preset through a discretization Langevin function and Fourier transform, and the in vivo temperature is solved through the relation without considering density information of the magnetic nanoparticles and variation, of effective magnetic moments, with the temperature during the solving process. Accurate detection of the in vivo temperature is achieved.

Description

technical field [0001] The invention relates to the technical field of nanometer testing, in particular to an in-body temperature measurement method and system based on the AC magnetization of magnetic nanoparticles. Background technique [0002] In vivo temperature refers to the temperature of tissues within an intact and living individual. In the field of biomedicine, in-body temperature measurement methods are divided into invasive measurement and non-invasive measurement. The invasive measurement method is simple, the measurement position is convenient for direct monitoring of the image, the measurement accuracy is high, and the temperature is measured in real time, but it causes greater trauma, and the insertion of the needle is easy to cause the transfer of diseased cells, and the radiation field of the heating source directly interacts with the probe. The decrease of measurement accuracy, the measured temperature data is point temperature, not the temperature field d...

AI Technical Summary

Problems solved by technology

The particle size and saturation magnetic moment can be determined in advance through accurate and repeated tests in vitro, but the concentration distribution of magnetic nanoparticles in the body is difficult to measure, and no measurement scheme has been proposed so far

However, the uncertainty of the concentration distribution and spatial distribution of magnetic nanoparticles in the body will lead to great errors in temperature measurement in vivo. problem to be solved

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