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Lanthanum hydroxide therapeutical effects on hyperphosphatemia and relative diseases

A technology of lanthanum hydroxide and hyperphosphatemia, applied in the field of new drug use of lanthanum hydroxide, can solve the problems of aluminum retention, side effects, hypercalcemia and the like

Inactive Publication Date: 2013-06-12
INNER MONGOLIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Traditional phosphorus binders are mainly aluminum or calcium-containing phosphorus binders, but long-term use of aluminum-containing phosphorus binders can lead to aluminum retention in the body and cause serious side effects, so it is only suitable for short-term use in high blood pressure that cannot be effectively controlled by other drugs. Phosphate
However, calcium-containing phosphate binders can lead to hypercalcemia, increase the calcium-phosphorus product, and cause metastatic calcification and cardiovascular disease. Therefore, traditional phosphate binders are not ideal drugs for the treatment of hyperphosphatemia.

Method used

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  • Lanthanum hydroxide therapeutical effects on hyperphosphatemia and relative diseases
  • Lanthanum hydroxide therapeutical effects on hyperphosphatemia and relative diseases
  • Lanthanum hydroxide therapeutical effects on hyperphosphatemia and relative diseases

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Embodiment Construction

[0018] Described in the present invention is the research carried out according to the method represented by the following implementation example. The methods involved are technical means that can be grasped and used by those skilled in the art, but the following implementation examples shall not be construed as limiting the claims of the present invention in any sense.

[0019] Implementation Example 1

[0020] Synthesis of Nanometer Lanthanum Hydroxide

[0021] (1) Materials and methods

[0022] 1 Instruments and reagents

[0023] Ph meter (Shanghai Shengci Instrument Co., Ltd., Shanghai 02220106); microscope (Shanghai Optical Instrument Factory, Cx31-32c02); magnetic stirrer (Shandong Heze Petrochemical School Instrument Equipment Factory, DHT type); electronic balance (Shanghai Haikang Electronic Instrument Factory, FA214); centrifuge (Hunan Xiangyi Laboratory Instrument Development Co., Ltd., H1850)

[0024] Lanthanum chloride (Inner Mongolia Baotou Steel Rare Earth H...

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Abstract

The invention relates to lanthanum hydroxide which has the functions of preparing and curing chronic renal failure (CRF), hyperphosphatemia or / and hyperparathyroidism (SHPT), vitamin D metabolic block, renal osteopathy and cardiovascular system calcification drugs, wherein the lanthanum hydroxide is nanometer lanthanum hydroxide, and daily dose of the lanthanum hydroxide or the nanometer lanthanum hydroxide is 600mg to 7800mg..

Description

technical field [0001] The present invention relates to the field of new application of medicine, in particular to the new application of lanthanum hydroxide. Background technique [0002] Phosphorus is one of the most abundant elements in the human body. It is mainly transported from the intestines to the body and mainly excreted from the kidneys. Under normal circumstances, the phosphorus excreted by the human body through the kidneys accounts for about 70% of the total excretion, and the phosphorus excreted through the feces accounts for about 30%. In the early stage of CRF, the metabolism of phosphorus changes. A mild increase in blood phosphorus accompanied by hypocalcemia causes an increase in the level of parathyroid hormone (PTH). The increase in PTH increases the stimulation of 1-α hydroxylase on the one hand, so that Kidney 1,25(OH) 2 D. 3 On the other hand, the rise of PTH reduces the reabsorption of phosphorus in renal tubules, increases the excretion of phosp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61P13/12A61P3/12A61P19/08A61P5/20A61P9/00
Inventor 李刚马慧侯峰尹若熙郭敏
Owner INNER MONGOLIA MEDICAL UNIV
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