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Production method of injection-use hydrogenated soybean lecithin

A technology of soybean lecithin and hydrogenated lecithin, which is applied in the field of medicine and chemical industry, can solve the problems of low catalyst activity, insufficient hydrogenation degree, high temperature of reaction conditions, etc., and achieves easy industrialization promotion and utilization, high hydrogen absorption rate, mild and acceptable reaction conditions. control effect

Active Publication Date: 2013-06-05
艾伟拓(江苏)医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The purpose of the present invention is to provide a method for preparing a soybean lecithin hydrogenation catalyst to solve the problems of low catalyst activity, high temperature and high pressure reaction conditions, and insufficient hydrogenation degree in the existing method for preparing a hydrogenation catalyst for soybean lecithin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Soy Lecithin Hydrogenated

[0037] Weigh 200g of soybean lecithin into a stainless steel reaction kettle, add 2 liters of absolute ethanol to dissolve, add catalyst amorphous NiB / diatomaceous earth-Pd / diatomaceous earth 3g, seal the reaction kettle, and feed hydrogen to 1MPa. The reaction was carried out at 70° C. for 1.5 hours in a collector type constant temperature heating magnetic stirrer.

[0038] Purification of Hydrogenated Soy Lecithin

[0039] After the above reaction is completed, the product is separated from the catalyst, and activated carbon is added for decolorization, filtered, and the solvent is removed. Silica gel column chromatography, the eluent is isopropanol-dichloromethane-n-hexane, the ratio is 1:1:1 (volume ratio). Remove the solvent and dry to obtain 190 g of hydrogenated soybean lecithin for injection, HPLC purity: 96.9%; iodine value: 16.

Embodiment 2

[0041] Soy Lecithin Hydrogenated

[0042] Weigh 200g soybean lecithin into a stainless steel reaction kettle, add 2 liters of absolute ethanol to dissolve, add catalyst amorphous NiB / diatomaceous earth-Pd / diatomaceous earth 5g, seal the reaction kettle, and feed hydrogen to 2MPa. The reaction was carried out at 70° C. for 5 hours in a collector type constant temperature heating magnetic stirrer.

[0043] Purification of Hydrogenated Soy Lecithin

[0044] After the above reaction is completed, the product is separated from the catalyst, and activated carbon is added for decolorization, filtered, and the solvent is removed. Silica gel column chromatography, the eluent is isopropanol-dichloromethane-n-hexane, the ratio is 1:1:1 (volume ratio). Remove the solvent and dry to obtain 188 g of hydrogenated soybean lecithin for injection, HPLC purity: 96.2%; iodine value: 15.5.

Embodiment 3

[0046] Soy Lecithin Hydrogenated

[0047] Weigh 200g of soybean lecithin into a stainless steel reaction kettle, add 2 liters of absolute ethanol to dissolve, add catalyst amorphous NiB / diatomaceous earth-Pd / diatomaceous earth 1g, seal the reaction kettle, and feed hydrogen to 0.5MPa. The reaction was carried out at 70° C. for 2 hours in a collector type constant temperature heating magnetic stirrer.

[0048] Purification of Hydrogenated Soy Lecithin

[0049] After the above reaction is completed, the product is separated from the catalyst, and activated carbon is added for decolorization, filtered, and the solvent is removed. Silica gel column chromatography, the eluent is isopropanol-dichloromethane-n-hexane, the ratio is 1:1:1 (volume ratio). Remove the solvent and dry to obtain 185 g of hydrogenated soybean lecithin for injection, HPLC purity: 95.8%; iodine value: 15.

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Abstract

The invention provides a preparation method of injection-use hydrogenated soybean lecithin. The method comprises specific processes that: soybean lecithin and a certain amount of a catalyst are added into a reaction vessel; a solvent is added, and the materials are dissolved; the reaction vessel is sealed; hydrogen is delivered in until a certain pressure is reached; constant-temperature reaction is carried out for a certain period of time in a collector-type constant temperature heating magnetic stirrer; when the reaction is finished, the product is separated from the catalyst; active carbon is added for discoloration; filtering is carried out, and the solvent is removed; and column chromatography purification is carried out, such that the hydrogenated soybean lecithin product is obtained. The method provided by the invention is suitable for process large-scale productions. The prepared hydrogenated soybean lecithin product can be used in medical injection liquid.

Description

technical field [0001] The invention relates to a production method of injectable hydrogenated soybean lecithin, which belongs to the field of medicine and chemical industry. Background technique [0002] Hydrogenated lecithin is made of soybean lecithin as raw material, extracted from high-purity lecithin, and then developed through catalytic hydrogenation process. The product is light yellow or milky white powder. Due to the use of catalytic and hydrogenation processes, the unsaturated chains of unsaturated fatty acids in the molecular structure of soybean lecithin disappear, thereby greatly improving the chemical stability, dispersibility, and emulsification of lecithin. It has decolorization and deodorization effects, is more conducive to storage and storage, and improves the role in medicine, high-grade cosmetics, and light industry. It is especially suitable for intravenous injection of fat emulsifier and nutrient. It is used as a blood lipid emulsifier to prevent a...

Claims

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Application Information

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IPC IPC(8): C07F9/10A61K9/08A61K47/24
Inventor 曹亮
Owner 艾伟拓(江苏)医药科技有限公司
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