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Preparation method of hydrogen-microbubble-containing aqueous solution, and product and application of method

An aqueous solution and hydrogen technology, applied in the field of biomedicine, can solve the problems of unstable concentration, difficult to control, short storage time, etc., and achieve the effects of improving solubility, reducing dosage and controllable concentration.

Active Publication Date: 2013-05-15
广州康臣药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The purpose of the present invention is to overcome the problems of low hydrogen solubility, unstable concentration, difficult control and short storage time in the hydrogen solution used for medical purposes in the prior art

Method used

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  • Preparation method of hydrogen-microbubble-containing aqueous solution, and product and application of method
  • Preparation method of hydrogen-microbubble-containing aqueous solution, and product and application of method
  • Preparation method of hydrogen-microbubble-containing aqueous solution, and product and application of method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Preparation of Hydrogen Microbubble Aqueous Solution

[0065] In S1, a certain amount of 1,2-arachidylglycerylphosphatidylcholine (20:0, PC) and 1,2-distearoylglycerylphosphatidylcholine modified by polyethylene glycol 2000 were added in a 90:10 molar ratio. Ethanolamine (DSPE-PEG) was mixed in chloroform with a vortex mixer. The chloroform was removed with a dry nitrogen flow to form a uniform film of the dissolved material on the wall of the test tube, and dried in a vacuum oven at 45°C for more than 2 hours.

[0066] S2 According to the total mass of the above-mentioned phospholipids, add a certain volume of buffer solution with a pH of 7.4 (containing 10% (volume ratio) glycerol, 10% (volume ratio) propylene glycol and 80% (volume ratio) 0.1M Tris Tris trihydroxyaminomethane) , the phospholipid mixture film was hydrated so that the final concentration of phospholipids was 3 mg / ml. Heat to above 70°C to make it fall off the wall of the test tube. Keep the water ...

Embodiment 2

[0086] Preparation of Hydrogen Microbubble Aqueous Solution

[0087] In S1, a certain amount of 1,2-docosyl fatty acylglyceryl phosphatidylcholine (22:0PC), polyethylene glycol 2000 modified 1,2-distearoyl Glycerylphosphatidylethanolamine (DSPE-PEG) was mixed in chloroform with a vortex mixer. The chloroform was removed with a dry nitrogen flow to form a uniform film of the dissolved material on the wall of the test tube, and dried in a vacuum oven at 45°C for more than 2 hours.

[0088] S2 According to the total mass of the above-mentioned phospholipids, add a certain volume of buffer solution with a pH of 7.4 (containing 10% (volume ratio) glycerol, 10% (volume ratio) propylene glycol and 80% (volume ratio) 0.1M Tris Tris trihydroxyaminomethane) , the phospholipid mixture film was hydrated so that the final concentration of phospholipids was 3 mg / ml. Heat to above 70°C to make it fall off the wall of the test tube. Keep the water temperature above 80°C with a water-bath...

Embodiment 3

[0094] Preparation of Hydrogen Microbubble Aqueous Solution

[0095] S1 A certain amount of 1,2-arachidylglycerylphosphatidylcholine (20:0, PC) and polyethylene glycol 2000 stearate (PEG40S) were mixed in chloroform with a vortex at a molar ratio of 85:15. Spin mixer to mix. The chloroform was removed with a dry nitrogen flow to form a uniform film of the dissolved material on the wall of the test tube, and dried in a vacuum oven at 45°C for more than 2 hours.

[0096] S2 According to the total mass of the above-mentioned phospholipids, add a certain volume of buffer solution with a pH of 7.4 (containing 10% (volume ratio) glycerol, 10% (volume ratio) propylene glycol and 80% (volume ratio) 0.1M Tris Tris trihydroxyaminomethane) , the phospholipid mixture film was hydrated so that the final concentration of phospholipids was 3 mg / ml. Heat to above 70°C to make it fall off the wall of the test tube. Keep the water temperature above 70°C with a water-bath ultrasonic oscilla...

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Abstract

The invention relates to a novel hydrogen-containing medicine dosage form. Hydrogen is made into a hydrogen-microbubble-containing aqueous solution in a manner of coating by phospholipid, so that the hydrogen content of the solution can greatly increase, the hydrogen concentration can be controlled, and the hydrogen is more stable. In addition, by virtue of a microbubble technology, the hydrogen-microbubble-containing aqueous solution can also be taken as an ultrasonic contrast agent and has multiple function effects.

Description

【Technical field】 [0001] The invention relates to the field of biomedicine, in particular to the preparation of hydrogen-containing microbubble aqueous solution, its products and applications. 【Background technique】 [0002] In recent years, the application of hydrogen in biomedicine has attracted increasing interest. [0003] Dole et al. (Science, 1975, 4210: 152-154) published a paper in the "Science" magazine that continuously breathed 8 atmospheres of 97.5% hydrogen (2.5% oxygen) for 14 days, and that high-pressure hydrogen can effectively treat animal skin malignant tumors. On the one hand It can reduce the concentration of oxygen, and on the other hand, increase the concentration of hydrogen in the body. [0004] French diving medical scientist Gharib et al. (Life Sciences, 2001, 324: 719-724) also reported that breathing 8 atmospheres of high-pressure hydrogen can treat the inflammatory response caused by liver parasite infection. It was first proved that hydrogen ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K33/00A61K49/22A61P1/16A61P9/10A61P13/12A61P29/00A61P35/00
Inventor 郑海荣严飞靳巧锋杨伟邓志婷
Owner 广州康臣药业有限公司
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