Production method for separation and purification of salidroside from rhodiola rosea

Abstract

The invention discloses a production method for separation and purification of salidroside from rhodiola rosea. The method comprises the following steps: after being smashed, raw materials are thrown in from a throwing hopper; a mainframe of an extraction tank set rotates; the materials are slowly propelled from the front end of the set to the back end; and at the same time, extraction solvent is introduced in the extraction tank from a liquid inlet pipe at the tail end of the set, and penetrates the movable materials from the back end of the tank to flow to the front end; and the solid-phase and liquid-phase materials are fully contacted with each other in the inverse movement so as to extract the effective components of medicinal materials. Medicine dregs are forcedly pushed to a dreg outlet through a discharge conveyer for discharging, and are extruded by using a special juice extruder to extrude residual medicine juice from medicinal material organizations, so that the content of the residual medicine juice of the medicine dregs is reduced, the extraction efficiency is higher, and the extraction is more thorough. The method chooses macroreticular resins and combines with the silica column chromatography to purify, so that better separation effect is achieved. Finished products of salidroside with the highest yield of 1% and the content above 95% can be obtained.

Description

Technical field: [0001] The invention belongs to the field of natural organic chemistry, and relates to a production method of salidroside, in particular to a production method of separating and purifying salidroside by using a macroporous adsorption resin coupled with silica gel column chromatography. Background technique: [0002] Rhodiola rosea Latin scientific name, English name Roseroot, alias, arctic root, golden root is a perennial herb or shrub of Crassulaceae, a rare wild plant that grows in the alpine and pollution-free areas at an altitude of 800-2500 meters. Rhodiola mainly contains phenylpropanoids and flavonoids. Its unique active chemical components are phenylpropanoid esters, rosavin (the most active), rosin, rosarin, rhodiolin, salidroside and its aglycone, namely p-tyrosol. It is used for improving sleep, promoting blood circulation, anti-brain hypoxia, anti-fatigue, promoting blood circulation and stopping bleeding, clearing lung and relieving cough, redu...

AI Technical Summary

Problems solved by technology

The salidroside extraction process in the above patent documents is mainly extracted through hot water extraction, chromatographic column separation and other steps. Although the final salidroside has a high purity, the process itself is expensive, and the actual application of effective raw materials is far away. Far inferior to macroporous adsorption resin coupling silica gel column chromatography separation and purification method to separate effective raw materials