Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Chinese medicinal composition for treating diabetic fatty liver and preparation process thereof

A technology of diabetes and preparation technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, metabolic diseases, etc., and can solve problems such as inconsistent treatment principles and lack of clinical drug efficacy research

Active Publication Date: 2013-04-17
HUNAN UNIV OF CHINESE MEDICINE
View PDF5 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, the combination of lipid-lowering and liver-protecting drugs is often used. Although it has a certain curative effect, most of them have relatively large adverse reactions, such as rebound after drug withdrawal, liver and kidney damage and other side effects in patients. It has its unique advantages in the treatment of diabetes, and has the advantages of long-lasting curative effect and no obvious side effects. However, at present, most traditional Chinese medicines for diabetes are single prescriptions and proven prescriptions, lack of systematic and perfect clinical efficacy research, and the prescriptions of traditional Chinese medicine are based on their own Different, the rules are not uniform

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chinese medicinal composition for treating diabetic fatty liver and preparation process thereof
  • Chinese medicinal composition for treating diabetic fatty liver and preparation process thereof
  • Chinese medicinal composition for treating diabetic fatty liver and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Take 5 parts of Coptis chinensis, 10 parts of Salvia miltiorrhiza, 5 parts of capillary, 10 parts of Polygonum cuspidatum, 10 parts of turmeric, 5 parts of tangerine peel, and 5 parts of licorice, powder them separately, pass through a 100-mesh sieve, mix the resulting fine powder, and extract 3 times in a conventional water bath And make dry extract. Grind the dry extract into a fine powder and add 95% ethanol to make the alcohol content of the liquid 50-70%, filter it after standing for 24 hours, mix it with the alcohol extract and dry it under vacuum at 70°C to obtain a fine powder of the drug. Drug fine powder: lactose: soluble starch is mixed in a ratio of 14:3:3, 95% ethanol of 3% PVP K30 is used as binder, 0.5% micronized silica gel is used as glidant, and 1% magnesium stearate is used as lubricant The agent is obtained by combining the granulation process and tableting process to make a film coating agent.

Embodiment 2

[0058] Take 20 parts of Coptis chinensis, 15 parts of Salvia miltiorrhiza, 10 parts of capillary root, 20 parts of Polygonum cuspidatum, 10 parts of turmeric, 15 parts of tangerine peel, and 10 parts of licorice, powder them separately, pass through a 100-mesh sieve, mix the resulting fine powder, and extract 3 times in a conventional water bath And make dry extract. Grind the dry extract into a fine powder and add 95% ethanol to make the alcohol content of the liquid 50-70%, filter it after standing for 24 hours, mix it with the alcohol extract and dry it under vacuum at 70°C to obtain a fine powder of the drug. Drug fine powder: lactose: soluble starch is mixed in a ratio of 14:3:3, 95% ethanol of 3% PVP K30 is used as binder, 0.5% micronized silica gel is used as glidant, and 1% magnesium stearate is used as lubricant The agent is obtained by combining the granulation process and tableting process to make a film coating agent.

Embodiment 3

[0060] Take 30 parts of Coptis chinensis, 30 parts of Salvia miltiorrhiza, 15 parts of capillary root, 30 parts of Polygonum cuspidatum, 30 parts of turmeric, 15 parts of tangerine peel, 15 parts of licorice, powder them separately, pass through a 100-mesh sieve, mix the resulting fine powder, and extract 3 times in a conventional water bath And make dry extract. Grind the dry extract into a fine powder and add 95% ethanol to make the alcohol content of the liquid 50-70%, filter it after standing for 24 hours, mix it with the alcohol extract and dry it under vacuum at 70°C to obtain a fine powder of the drug. Drug fine powder: lactose: soluble starch is mixed in a ratio of 14:3:3, 95% ethanol of 3% PVP K30 is used as binder, 0.5% micronized silica gel is used as glidant, and 1% magnesium stearate is used as lubricant The agent is obtained by combining the granulation process and tableting process to make a film coating agent.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention particularly relates to a Chinese medicinal composition for treating diabetic fatty liver and a preparation process thereof. The preparation process comprises the following steps of: weighing 5 to 30 parts of golden thread, 10 to 30 pars of red-rooted salvia root, 5 to 15 parts of oriental wormwood, 10 to 30 parts of giant knot weed, 10 to 30 parts of turmeric root-tuber, 5 to 15 parts of dried tangerine peel, and 5 to 15 parts of liquorice; respectively crushing into powder, screening through a 100-mesh screen, mixing all fine powders, and extracting 3 times with conventional water bath to prepare dry extract; grinding the dry extract into fine powder, adding 95 percent ethanol to allow the alcohol content of liquid medicine to be between 50 and 70 percent, standing and filtering, mixing with ethanol extract in vacuum at 70 DEG C, and drying to obtain medicinal fine powder; and mixing the medicinal fine powder, lactose and soluble starch in a mass ratio of 14 to 3 to 3, and preparing the Chinese medicinal composition by using 3 percent of 95 percent ethanol of PVP (polyvinylpyrrolidone) K30 as adhesive, 0.5 percent of aerosol as glidant and 1 percent of magnesium stearate as a lubricant.

Description

technical field [0001] The invention specifically relates to a traditional Chinese medicine composition for treating diabetic fatty liver and a preparation process thereof. Background technique [0002] "Diabetes" is a disease in which glucose in the blood tends to accumulate excessively. There are currently more than 92 million diabetics in my country, and another 150 million people will become diabetics. It has become the third largest disease after tumors and cardiovascular diseases. Ultrasound detection method found that about 21%-78% of type 2 diabetes patients have fatty liver (adiponectin level and related factors in patients with non-alcoholic fatty liver such as Wang Xiaowei. "Inner Mongolia Traditional Chinese Medicine" 2008 (11): 127), According to epidemiological statistics, diabetic fatty liver has also become the most common type of fatty liver family, accounting for 50%-60%. Diabetic fatty liver is caused by insufficient or relative lack of insulin secretion ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/9066A61P3/10A61P1/16
Inventor 喻嵘吴勇军吴钰
Owner HUNAN UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products